Perineuronal Glial Reactions in Regeneration of Motoneurons

  • Georg W. Kreutzberg
Part of the Altschul Symposia Series book series (ALSS, volume 2)


The response of nerve cells to axonal lesion, which is referred to as axonal or retrograde reaction or chromatolysis, is essentially a selective hypertrophy. Synthesis of specific proteins, peptides, enzymes, etc. have been described as well as an increase in the size of the cell body, the metabolism and the perineuronal glia. Glial cells also participate in the axonal reaction, and in quite a complex way (Barron et al., 1971; Lieberman, 1971; Graeber and Kreutzberg, 1990; Tetzlaff et al., 1988a; Kreutzberg et al., 1988).


Motor Neuron Microglial Cell Facial Nucleus Glial Process Brain Macrophage 
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  1. Adams, I., and Jones, D.G., 1982, Synaptic remodelling and astrocytic hypertrophy in rat cerebral cortex from early to late adulthood, Neurobiol. of Aging, 3: 179.CrossRefGoogle Scholar
  2. Banati, R.B., Rothe, G., Valet, G., and Kreutzberg, G.W., 1991, Respiratory burst activity in brain macrophages: a flow cytometric study on cultured rat microglia, Neuropathol. and Appl. Neurobiol. 17: 223.CrossRefGoogle Scholar
  3. Barron, K.D., Chiang, T.Y., Daniels, A.C., and Doolin, P.F., 1971, Subcellular accompaniments of axon reaction in cervical motoneurons of the cat, in: “Progress in Neuropathology”, H.M. Zimmerman, ed, Vol. 1, Grune & Stratton, New York.Google Scholar
  4. Blinzinger, K., and Kreutzberg, G., 1968, Displacement of synaptic terminals from regenerating motoneurons by microglial cells, Z. Zellforsch. 85: 145.PubMedCrossRefGoogle Scholar
  5. Chen, D.H., 1978, Qualitative and quantitative study of synaptic displacement in chromatolyzed motoneurons of the cat, J. Comp. Neurol. 177: 635.PubMedCrossRefGoogle Scholar
  6. Colton, A.C., and Gilbert, D.L., 1987, Production of superoxide by a CNS macrophage, the microglia, FEBS Letts. 223: 284.CrossRefGoogle Scholar
  7. Copray, J.C.V.M., Liem, R.S.B., and van Willigen, J.D., 1990, Morphological arrangement between astrocytes and trigeminal mesencephalic primary afferent neurons in the rat, Exp. Brain Res. 83: 215.PubMedCrossRefGoogle Scholar
  8. Engel, A.K., and Kreutzberg, G.W., 1988, Neuronal surface changes in the dorsal vagal motor nucleus of the guinea pig in response to axotomy, J. Comp. Neurol. 275: 181.PubMedCrossRefGoogle Scholar
  9. Gehnnann, J., and Kreutzberg, G.W., 1991, Characterisation of two new monoclonal antibodies directed against rat microglia, J. Comp. Neurol. 313: 409.CrossRefGoogle Scholar
  10. Goshgarian, H.G., Yu, X.-J., and Rafols, J.A., 1989, Neuronal and glial changes in the rat phrenic nucleus occurring within hours after spinal cord injury, J. Comp. Neurol. 284: 519.PubMedCrossRefGoogle Scholar
  11. Graeber, M.B., and Kreutzberg, G.W., 1986, Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons, J. Neurocytol. 15: 363.PubMedCrossRefGoogle Scholar
  12. Graeber, M.B., and Kreutzberg, G.W., 1988, Delayed astmcyte reaction following facial nerve axotomy, J. Neurocytol. 17: 209.PubMedCrossRefGoogle Scholar
  13. Graeber, M.B., and Kreutzberg, G.W., 1990, Astrocytic reactions accompanying motor neuron regeneration, in: “Advances in Neural Regeneration Research”, J. Seil, ed., Wiley-Liss, New York.Google Scholar
  14. Graeber, M.B., Streit, W.J., and Kreutzberg, G.W., 1988a, The microglial cytoskeleton: vimentin is localized within activated cells in situ. J. Neurocytol. 17: 573.CrossRefGoogle Scholar
  15. Graeber, M.B., Streit, W.J., and Kreutzberg, G.W., 1988b, Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells, J. Neurosci. Res. 21: 18.PubMedCrossRefGoogle Scholar
  16. Graeber, M.B., Tetzlaff, W., Streit, W.J., and Kreutzberg, G.W., 1988c, Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy, Neurosci. Lett. 85: 317.PubMedCrossRefGoogle Scholar
  17. Guldner, F.H., and Wolff, J.R., 1973, Multi-lamellar astroglial wrapping of neuronal elements in the hypothalamus of rat, Experientia 29: 1355.PubMedCrossRefGoogle Scholar
  18. Hollander, H., Makarov, F., Dreher, Z., van Driel, D., Chan-Ling, T., and Stone, J., 1991, Structure of the macroglia of the retina: sharing and division of labour between astrocytes and Müller cells, J. Comp. Neurol. 313: 587.PubMedCrossRefGoogle Scholar
  19. Kreutzberg, G.W., 1966, Autoradiographische Untersuchung uber die Beteiligung von Gliazellen an der axonalen Reaktion im Facialiskem der Ratte, Acta Neuropathol. (Berl.) 7: 149.CrossRefGoogle Scholar
  20. Kreutzberg, G.W., and Barron, K.D., 1978, 5’-Nucleotidase of microglial cells in the facial nucleus during axonal reaction, J. Neurocytol. 7: 601.Google Scholar
  21. Kreutzberg, G.W., Engel, A.K., Graeber, M.B., Tetzlaff, W., and Toth, L., 1988, Structural plasticity in lesioned motoneurons, in: “Post-Lesion Neural Plasticity”, H. Rohr, ed., Springer, Berlin.Google Scholar
  22. Kreutzberg, G.W., Graeber, M.B., and Streit, W.J., 1989, Neuron-glial relationship during regeneration of motomeurons, Metabolic Brain Disease 4: 81.PubMedCrossRefGoogle Scholar
  23. Lieberman, A.R., 1971, The axon reaction: a review of the principal features of perikaryal responses to axon injury, Int. Rev. Neurobiol. 14: 49.PubMedCrossRefGoogle Scholar
  24. Lux, H.D., and Schubert, P., 1975, Some aspects of the electroanatomy of dendrites, in: “Physiology and Pathology of Dendrites. Advances in Neurology”, G. W. Kreutzberg, ed., Vol. 12, Raven Press, New York.Google Scholar
  25. Meshul, Ch.K., Seil, F.J., and Hemdon, R.M., 1987, Astrocytes play a role in regulation of synaptic density, Brain Res. 402: 139.PubMedCrossRefGoogle Scholar
  26. Montagnese, C., Poulain, D.A., and Theodosis, D.T., 1990, Influence of ovarian steroids on the ultrastructural plasticity of the adult rat supraoptic nucleus induced by central administration of oxytocin, J. Neuroendocrinol. 2: 225.PubMedCrossRefGoogle Scholar
  27. Olmos, G., Naftolin, F., Perez, J., Tranque, P.A., and Garcia-Segura, L.M., 1989, Synaptic remodeling in the rat arcuate nucleus during the estrous cycle, Neurosci. 32: 663.CrossRefGoogle Scholar
  28. Peters, A., Palay, S.L. and Webster, H.deF., 1970, “The Fine Structure of the Nervous System: The cells and their processes”, Harper & Row Publ., New York.Google Scholar
  29. Perlmutter, L.S., Tweedle, C.D., and Hatton, G.I., 1985, Neuronal/glial plasticity in the supraoptic dendritic zone in response to acute and chronic dehydration, Brain Res. 361: 225.PubMedCrossRefGoogle Scholar
  30. Raivich, G., Gehrmann, J., and Kreutzberg, G.W., 1991, Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus, J. Neurosci. Res. 30: 682.PubMedCrossRefGoogle Scholar
  31. Reisert, I., Wildemann, G., Grab, D., and Pilgrim, Ch., 1984, The glial reaction in the course of axon regeneration: a stereological study of the rat hypoglossal nucleus, J. Comp. Neurol. 229: 121.PubMedCrossRefGoogle Scholar
  32. Ronnevi, L.-O., 1978, Origin of the glial processes responsible for the spontaneous postnatal phagocytosis of boutons on cat spinal motoneurons, Cell Tiss. Res. 189: 203.Google Scholar
  33. Streit, W.J., and Kreutzberg, G.W., 1988, Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin, J. Comp. Neurol. 268: 248.PubMedCrossRefGoogle Scholar
  34. Streit, W.J., Graeber, M.B., and Kreutzberg, G.W., 1988a, Functional plasticity of microglia: a review, Glia 1: 301.PubMedCrossRefGoogle Scholar
  35. Tetzlaff, W., Bisby, M.A., and Kreutzberg, G.W., 1988a, Changes in cytoskeletal proteins in the rat facial nucleus following axotomy, J. Neurosci. 8: 3181.PubMedGoogle Scholar
  36. Tetzlaff, W., Graeber, M.B., Bisby, M.A., and Kreutzberg, G.W., 1988b, Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus, Glia 1: 90.PubMedCrossRefGoogle Scholar
  37. Torvik, A., and Soereide, A.J., 1972, Nerve cell regeneration after axon lesions in newborn rabbits, J. Neuropathol. Exp. Neurol. 31: 683.PubMedCrossRefGoogle Scholar
  38. Tweedle, C.D., and Hatton, G.I., 1976, Ultrastructural comparisons of neurons of supraoptic and circularis nuclei in normal and dehydrated rats, Brain Res. Bull. 1: 103.PubMedCrossRefGoogle Scholar
  39. Tweedle, C.D. and Hatton, G.I., 1977, Ultrastructural changes in rat hypothalamic neurosecretory cells and their associated glia during minimal dehydration and rehydration, Cell Tiss. Res. 181: 59.Google Scholar
  40. Zielasek, J., Tausch, M., Toyka, K.V., and Hartung, H.-P., 1992, Production of nitrite by neonatal rat microglial cells/brain macrophages, Cellular Immunol. 141: 111.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Georg W. Kreutzberg
    • 1
  1. 1.Max-Planck-Institute of PsychiatryMartinsriedGermany

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