Abstract
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine with a diverse variety of biological functions on a wide range of cells (for review see Beutler and Cerami 1989; Vilcek and Lee 1991). TNF-α has especially been recognized as being one of the proinflammatory cytokines in a number of tissues, including the brain. Astrocytes, the most abundant glial cell in the brain, have been shown to be capable of producing many cytokines upon stimulation, including TNF-α (for review see Benveniste 1992). TNF-α is an important mediator of both inflammatory and immunological responses in the brain due to its interaction with astrocytes. TNF-α mediated responses include: 1) enhancement of ICAM-1 on human fetal astrocytes (Frohman et al. 1989); 2) enhancement of class II major histocompatibility complex (MHC) expression on astrocytes through its synergistic interaction with interferon-gamma (IFN-γ) or virus (Massa et al. 1987; Benveniste et al. 1989); 3) proliferation of adult astrocytes (Selmaj et al. 1990); and 4) induction of interleukin-6 (IL-6) production by astrocytes (Frei et al. 1989; Benveniste et al. 1990). Additionally, TNF-α may act as an autocrine regulator of astrocyte function as these cells both produce TNF-α (Robbins et al. 1987; Lieberman et al. 1989; Chung and Benveniste 1990) and express high affinity TNF-α receptors (Benveniste et al. 1989). TNF-α may also contribute to demyelination within the central nervous system (CNS) due to its ability to lyse oligodendrocytes, the myelin producing cell in the CNS (Robbins et al. 1987), and induce myelin damage (Selmaj and Raine 1988).
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References
Asano T and H Hidaka, 1984, Vasodilatory action of HA 1004 (N-(2-guanidimethyl) -5isoquinolinesulfonamide}, a novel calcium antagonist with no effect on cardiac function., J. Pharmacol. Exp. Ther. 231: 141–145.
Benveniste EN, 1992, Cytokines: Influence on glial cell gene expression and function, in: “Chemical Immunology: Neuroimmunoendocrinology”, J. E. Blalock, ed., (S. Karger, Basel ), Vol. 52, 106–153.
Benveniste EN, SM Sparacio and JR Bethea, 1989, Tumor necrosis factor-a enhances interferon y mediated Class II antigen expression on astrocytes, J. Neuroimmunol. 25: 209–219.
Benveniste EN, SM Sparacio, JG Norris, HE Grenett and GM Fuller, 1990, Induction and regula- tion of interleukin-6 gene expression in rat astrocytes, J. Neuroimmunol. 30: 201–212.
Bethea JR, IY Chung, SM Sparacio, GY Gillespie and EN Benveniste, 1992a, Interleukin-lß induction of tumor necrosis factor-alpha gene expression in human astroglioma cells, J. Neuroimmunol. 36: 179–191.
Bethea JR, GY Gillespie and EN Benveniste, 1992b, Interleukin-113 induction of TNF-a gene expression: Involvement of protein kinase C, J. Cell. Physiol. 152: 264–273.
Beutler B and A Cerami, 1987, Cachectin: More than a tumor necrosis factor, New Engl. J. Med. 316: 379–385.
Beutler B and A Cerami, 1989, The biology of cachectin/INF-A primary mediator of the host response, Ann.Rev. /mmunol. 7: 625–655.
Beutler BA, IW Milsark and A Cerami, 1985, Cachectin/tumor necrosis factor: Production, distribution, and metabolic fate in vivo, J. Immunol. 135: 3972–3977.
Brett J, H Gerlach, P Nawroth, S Steinberg, G Godman and D Stern, 1989, Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins, J.Exp. Med. 169: 1977–1991.
Celada A and RA Maki, 1991, IFN-’y induced the expression of the genes for MHC class II I-Aß and tumor necrosis factor through a protein kinase C-independent pathway, J. Immunol. 146: 114–120.
Chantry D, M Turner, E Abney and M Feldmann, 1989, Modulation of cytokine production by transforming growth factor ß, J. Immunol. 142: 4295–4300.
Chung IY and EN Benveniste, 1990, Tumor necrosis factor-alpha production by astrocytes: Induction by lipopolysaccharide, interferon-gamma and interleuldn-1, J. Immunol. 144: 2999–3007.
Chung IY, JG Norris and EN Benveniste, 1991, Differential TNF-a expression by astrocytes from experimental allergic encephalomyelitis susceptible and resistant rat strains., J. Exp. Med. 173: 801–811.
Descoteaux A and G Matlashewski, 1990, Regulation of tumor necrosis factor gene expression and protein synthesis in murine macrophages treated with recombinant tumor necrosis factor, J. Immunol. 145: 846–853.
Frei K, UV Malipiero, TP Leist, RM Zinkernagel, ME Schwab and A Fontana, 1989, On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases, Eur. J. Immunol. 19: 689–694.
Frei K, C Siepl, P Groscurth, S Bodmer, C Schwerdel and A Fontana, 1987, Antigen presentation and tumor cytotoxicity by interferon-y-treated microglial cells, Eur. J. Immunol. 17: 1271–1278.
Frohman EM, TC Frohman, ML Dustin, B Vayuvegula, B Choi, A Gupta, S van den Noort and S Gupta, 1989, The induction of intracellular adhesion molecule 1 (ICAM 1) expression on human fetal astrocytes by interferon-y, tumor necrosis factor-a, lymphotoxin, and interleukin-l: relevance to intracerebral antigen presentation, J. Neuroimmunol. 23: 117–124.
Hidaka H, M Inagaki, S Kawamoto and Y Sasaki, 1984, Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C, Biochemistry 23: 5036–5041.
Hofman FM, DR Hinton, K Johnson and JE Merrill, 1989, Tumor necrosis factor identified in multiple sclerosis brain, J. Exp. Med. 170: 607–612.
Horiguchi J, D Spriggs, K Imamura, R Stone, R Luebbers and D Kufe, 1989, Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester, Mol. Cell. Biol. 9: 252–258.
Jongeneel CV, 1992, The TNF and lymphotoxin promoters, in: “Tumor Necrosis Factor. The Molecules and Their Emerging Role in Medicine”, B. Beutler, ed., Raven Press, New York, 539–559.
Kovacs EJ, D Radzioch, HA Young and L Varesio, 1988, Differential inhibition of IL-1 and TNF-a mRNA expression by agents which block second messenger pathways in murine macrophages, J. Immunol. 141: 3101–3105.
Lieberman AP, PM Pitha, HS Shin and ML Shin, 1989, Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus, Proc. Natl. Acad. Sci. USA 86: 6348–6352.
Lieberman AP, PM Pitha and ML Shin, 1990, Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes, J. Exp. Med. 172: 989–992.
Lieberman AP, PM Pitha and ML Shin, 1992, Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay, J. Biol. Chem. 267: 2123–2126.
Massa PT, A Schmipl, E Wecker and V ter Meulen, 1987, Tumor necrosis factor amplifies virus-mediated la induction on astrocytes, Proc. Natl. Acad. Sci. USA 84: 7242–7245.
Mohri M, DR Spriggs and D Kufe, 1990, Effects of lipopolysaccharide on phopholipase A2 activity and tumor necrosis factor expression in HL-60 cells, J. Immunol. 144: 2678–2682.
Pohlman TH, KA Stanness, PG Beatty, HD Ochs and JM Harlan, 1986, An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherance by a cd18-dependent mechanism, J. Immunol. 136: 4548–4553.
Robbins DS, Y Shirazi, BE Drysdale, A Lieberman, HS Shin and ML Shin, 1987, Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes, J. Immunol. 139: 2593–2597.
Ruddle NH, CM Bergman, KM McGrath, EG Lingenheld, ML Grunnet, SJ Padula and RB Clark, 1990, An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis, J. Exp. Med. 172: 1193–1200.
Selmaj K, CS Raine, B Cannella and CF Brosnan, 1991, Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions, J. Clin. Invest. 87: 949–954.
Selmaj KW, M Farooq, WT Norton, CS Raine and CF Brosnan, 1990, Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor, J. Immunol. 144: 129–135.
Selmaj KW and CS Raine, 1988, Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro., Ann. Neurol. 23: 339–346.
Sherman ML, R Datta, DE Hallahan, RR Weichselbaum and DW Kufe, 1991, Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes, J.Clin. Invest. 87: 1794–1797.
Tamaoki T, H Nomoto, I Takahashi, Y Kato, M Morimoto and F Tornita, 1986, Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase, Biochem. Biophys. Res. Commun. 135: 397–402.
Trede NS, RS Geha and T Chatila, 1991, Transcriptional activation of IL-lß and tumor necrosis factor-a genes by MHC class II ligands, J. Immunol. 146: 2310–2315.
Vilcek J and TH Lee, 1991, Tumor necrosis factor, J. Biol. Chem. 266: 7313–7316.
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Chung, I.Y., Kwon, J.B., Benveniste, E.N. (1993). Regulation of Tumor Necrosis Factor-Alpha Gene Expression in the Astrocyte. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_21
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