The Role of 5-HT1A Receptors in Development and Adult Plasticity of the Serotonergic System

  • Patricia M. Whitaker-Azmitia
  • Efrain C. Azmitia
Part of the Altschul Symposia Series book series (ALSS, volume 2)

Abstract

Astroglial cells play important roles in determining brain structure and function throughout life; the astrocyte must be able to change its function in order to play the appropriate age-dependent role. One such role is the production of neuronal growth factors. During development, the astrocyte may produce and release large amounts of growth factors, while in mature states, the astrocytes may produce and release very low levels, just enough to aid in synaptic turnover. In responding to a lesion of the neuron, the astrocyte may again greatly increase its growth factor output.

Keywords

Down Syndrome Serotonergic Neuron Neurotransmitter Receptor Astroglial Cell Trophic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Allore, R., O’Hanlon, D., Price, R., Neilson, K., Willard, H.F., Cox, D.R., Marks, A. and Dunn, R.J., Gene encoding the beta subunit of S-100 protein is on chromosome 21: Implications for Down Syndrome, Science. 239: 1311–1313, 1988.PubMedCrossRefGoogle Scholar
  2. Azmitia, E.C., Dolan, K. and Whitaker-Azmitia, P.M., S-100 beta, but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor, Brain Res. 576: 354–356, 1990.CrossRefGoogle Scholar
  3. Azmitia, E.C., Buchan, A.M. and Williams, J.H., Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons, Nature. 274: 374–377, 1978.PubMedCrossRefGoogle Scholar
  4. Bar-Peled, O., Gross-Isseroff, R., Ben-Hur, H. Hoskins, I., Groner, Y. and Biegon, A., Fetal human brain exhibits a prenatal peak in the density of 5-HT1a receptors, Neurosci. Leu. 127: 173–176, 1991.CrossRefGoogle Scholar
  5. Cross, A.J., Serotonin in Alzheimer-type dementia and other dementing diseases, New York Acad. Sci. 600: 405–417, 1990.CrossRefGoogle Scholar
  6. Daval, G., Verge, D., Becerril, A., Gozlan, H., Spampinato, U. and Hamon, M., Transient expression of 5-HTIa receptor binding sites in some areas of the rat CNS during postnatal development, In. J. Devi. Neurosci. 5: 171–189, 1987.CrossRefGoogle Scholar
  7. Griffin, W.S.T., Stanley, L.C., Ling, C., White, L., MacLeod, V., Perrot, L.T., White, C.L. and Araos, C., Brain interleukin 1 and S-100 immunoreactivity are elevated in Down Syndrome and Alzheimer Disease, Proc. Natl. Acad. Sci. 86: 7611–7615, 1989.PubMedCrossRefGoogle Scholar
  8. Kligman, D. and Marshak, D.R., Purification and characterization of a neurite extension factor from bovine brain, Proc. Natl. Acad. Sci. 82: 7136–7139, 1985.PubMedCrossRefGoogle Scholar
  9. Lauder, J., Hormonal and humoral influences on brain development, Psychoneuroendocrinology, 8: 121–155, 1983.PubMedCrossRefGoogle Scholar
  10. Marshak, D.R., Comparative biochemistry of drug-binding proteins in the calmodulin/S-100 family, Dissertation, The Rockefeller University, New York, 1983.Google Scholar
  11. Middlemiss, D.N., Palmer, A.M., Edel, N., and Bowen, D.M., Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain, J. Neurochem. 46: 993–996, 1986.PubMedCrossRefGoogle Scholar
  12. Muller, C.M., Antiserum against the astroglial protein interferes with ocular dominance plasticity in kitten visual cortex, Soc. Neurosci. Abstr. 15: 795, 1989.Google Scholar
  13. Schwartz, J.P and Costa, E., Regulation of nerve growth factor in C6 glioma cells by betaadrenergic receptor stimulation, Arch. Pharmacol. 300: 123, 1977.CrossRefGoogle Scholar
  14. Schroer, J.A. and Haring, J.H., Hippocampal 5-HT innervation influences the expression of GFAP and S-100 detected by immunocytochemistry, Soc. Neurosci. Abstr. 17: 934, 1991.Google Scholar
  15. Van Hartesveldt, C., Moore, B. and Hartman, B.K., Transient mid raphe glial structure in the developing rat, J. Comp. Neurol. 253: 175–184.Google Scholar
  16. Whitaker-Azmitia, P.M. and Azmitia, E.C., 3H-5-Hydroxytryptamine binding to brain astroglial cells: Differences between intact and homogenized preparations and mature and immature cultures, J. Neurochem. 46: 1186–1190, 1986.PubMedCrossRefGoogle Scholar
  17. Whitaker-Azmitia, P.M. and Azmitia, E.C., Stimulation of astroglial 5- HTla receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology, Brain Res. 528: 155–158, 1990.PubMedCrossRefGoogle Scholar
  18. Whitaker-Azmitia, P.M. and Azmitia, E.C., Stimulation of astroglial serotonin receptors produces culture media which regulates growth of serotonergic neurons, Brain Res. 497: 80–85, 1989.PubMedCrossRefGoogle Scholar
  19. Zhou, F.C. and Azmitia, E.C. Denervation of serotonergic fibers in the hippocampus induced a trophic factor which enhances the maturation of transplanted serotonergic but not noradrenergic neurons, J. Neurosci. Res. 17: 235–248, 1987.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Patricia M. Whitaker-Azmitia
    • 1
  • Efrain C. Azmitia
    • 2
  1. 1.Dept. of PsychiatryState University of New York at Stony BrookStony BrookUSA
  2. 2.Dept. of BiologyNew York UniversityNew YorkUSA

Personalised recommendations