Abstract
Astroglial cells, which constitute the most numerous cellular population of the central nervous system (CNS) (Pope, 1978), exert a wide variety of functions (for a review, see (Fedoroff and Vernadakis, 1986)) including: i) a connective tissue-like role, ii) the ensheathment and hence the isolation of synaptic complexes, iii) the regulation of local extracellular ionic concentration and pH level, iv) the uptake, metabolism and compartmentalization of neurotransmitters, v) the control of blood-CNS exchanges through the astrocyte capillary investment and vi) the control of developmental neuronal migration through neuronal guidance. Given the variety and the importance of the functions devoted to astrocytes, it is likely that the proliferation of these cells during development and in adulthood must be under tight control in order to allow an harmonious ontogenesis and functioning of the CNS.
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Rogister, B., Leprince, P., Martin, D., Schoenen, J., Moonen, G. (1993). Neuronal Control of Astrocyte Proliferation. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_17
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