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Biology and Pathology of Astrocyte-Neuron Interactions pp 181–191Cite as

How Does Thrombin Cause Neurite Retraction ?

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Part of the book series: Altschul Symposia Series ((ALSS,volume 2))

Abstract

Recent studies have established that thrombin modulates neuronal and glial cytoarchitecture. Thrombin antagonizes the neurite promoting activity of its inhibitor glia-derived nexin (Monard et al., 1983) and induces neurite retraction in mouse NB2a and human SK-N-SH neuroblastoma cells (Gurwitz and Cunningham, 1988; Grand et al., 1989), cultured human cerebellar and hippocampal neurons, and in AD12 HER10 cells of neuroepithelial origin (Grand et al., 1989; Grabham et al., 1991). Mouse dorsal root ganglion neurons grow shorter neuntes in the presence of thrombin (Hawkins and Seeds, 1986) and neuntes turn away from a source of thrombin placed in the culture system (Hawkins and Seeds, 1989). Thrombin has also been reported to reverse the cyclic AMP-induced stellation of cultured astrocytes and glioma cells (Cavanaugh et al., 1990, Nelson and Siman, 1990; Tas and Koschel, 1990).

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  1. Friedrich Miescher-Institut, P.O.Box 2543, Basel, CH-4002, Switzerland

    Hana S. Suidan & Denis Monard

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  1. Hana S. Suidan
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  2. Denis Monard
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  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Sergey Fedoroff , Bernhard H. J. Juurlink  & Ronald Doucette ,  & 

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Suidan, H.S., Monard, D. (1993). How Does Thrombin Cause Neurite Retraction ?. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_16

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  • DOI: https://doi.org/10.1007/978-1-4757-9486-1_16

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