How Does Thrombin Cause Neurite Retraction ?

  • Hana S. Suidan
  • Denis Monard
Part of the Altschul Symposia Series book series (ALSS, volume 2)


Recent studies have established that thrombin modulates neuronal and glial cytoarchitecture. Thrombin antagonizes the neurite promoting activity of its inhibitor glia-derived nexin (Monard et al., 1983) and induces neurite retraction in mouse NB2a and human SK-N-SH neuroblastoma cells (Gurwitz and Cunningham, 1988; Grand et al., 1989), cultured human cerebellar and hippocampal neurons, and in AD12 HER10 cells of neuroepithelial origin (Grand et al., 1989; Grabham et al., 1991). Mouse dorsal root ganglion neurons grow shorter neuntes in the presence of thrombin (Hawkins and Seeds, 1986) and neuntes turn away from a source of thrombin placed in the culture system (Hawkins and Seeds, 1989). Thrombin has also been reported to reverse the cyclic AMP-induced stellation of cultured astrocytes and glioma cells (Cavanaugh et al., 1990, Nelson and Siman, 1990; Tas and Koschel, 1990).


Neuroblastoma Cell Neurite Outgrowth Protein Kinase Inhibitor Neurite Length Thrombin Receptor 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Hana S. Suidan
    • 1
  • Denis Monard
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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