Dynein-Microtubule Interactions

  • Nicolas J. Cordova
  • Ronald D. Vale
  • George F. Oster
Part of the NATO ASI Series book series (NSSB, volume 263)


Vale and his colleagues (1989) devised a method of attaching single dynein molecules to a substrate and observing the motion of microtubules. In one series of experiments they inhibited the enzymatic activity of the dynein with vanadate. By fitting a Gaussian to this data, they obtained the diffusion constants shown in Table 1. However, according to the theoretical formulas for longitudinal and transverse diffusion of a cylinder these diffusion constants should be much larger. (The longitudinal and transverse diffusion coefficients are given by the following expressions: D L = kTln(2h/r)/2πηL and D T = kTln(2h/r)/4πηL (Brennen and Winet, 1977)). This discrepancy suggests two models for the interaction.


Diffusion Constant Transverse Diffusion Apparant Diffusion Constant Constant Standard Deviation Instantaneous Point Source 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Nicolas J. Cordova
    • 1
  • Ronald D. Vale
    • 2
  • George F. Oster
    • 3
  1. 1.Department of Applied MathematicsWeizmann Institute of ScienceRehovotIsrael
  2. 2.Department of PharmacologyUniversity of California School of MedicineSan FranciscoUSA
  3. 3.Departments of Molecular and Cell Biology, and EntomologyUniversity of CaliforniaBerkeleyUSA

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