An Oxidant Sensor at the Plasma Membrane

  • Axel Knebel
  • Mihail Iordanov
  • Hans J. Rahmsdorf
  • Peter Herrlich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

The expression of genes is predominantly determined by conditions of the microenvironment of cells. Prime examples of such regulation are found in embryonic development of all multicellular organisms and also in the adult when various cytokines and hormones exert highly inducer-specific influences on genes. The naturally occurring regulating agents interact with specific receptors: e.g., the retinoids, vitamin D3, thyroid hormones and the steroid hormones with appropriate nuclear receptors (RARs, RXRs, VDR and the specific steroid hormone receptors), or the members of the large TGFβ and FGF families with their respective cell surface receptors. While nuclear receptors act as transcription factors themselves and select their genes by receptor-specific recognition elements, the growth factors induce, through their cell surface receptors, a complex process of signal transduction to the nucleus (for reviews see Beato, 1989; Karin, 1994; Gilbert, 1994; Angel and Herrlich, 1994; McCormick, 1995; Howe and Weiss, 1995; Ullrich and Simon, 1995).

Keywords

Heat Shock Factor Potassium Permanganate Reactive Oxygen Intermediate Familial Amyotrophic Lateral Sclerosis Transcription Factor NFKB 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Axel Knebel
    • 1
  • Mihail Iordanov
    • 1
  • Hans J. Rahmsdorf
    • 1
  • Peter Herrlich
    • 1
  1. 1.Forschungszentrum KarlsruheInstitut für GenetikKarlsruheGermany

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