An Oxidant Sensor at the Plasma Membrane
The expression of genes is predominantly determined by conditions of the microenvironment of cells. Prime examples of such regulation are found in embryonic development of all multicellular organisms and also in the adult when various cytokines and hormones exert highly inducer-specific influences on genes. The naturally occurring regulating agents interact with specific receptors: e.g., the retinoids, vitamin D3, thyroid hormones and the steroid hormones with appropriate nuclear receptors (RARs, RXRs, VDR and the specific steroid hormone receptors), or the members of the large TGFβ and FGF families with their respective cell surface receptors. While nuclear receptors act as transcription factors themselves and select their genes by receptor-specific recognition elements, the growth factors induce, through their cell surface receptors, a complex process of signal transduction to the nucleus (for reviews see Beato, 1989; Karin, 1994; Gilbert, 1994; Angel and Herrlich, 1994; McCormick, 1995; Howe and Weiss, 1995; Ullrich and Simon, 1995).
KeywordsHeat Shock Factor Potassium Permanganate Reactive Oxygen Intermediate Familial Amyotrophic Lateral Sclerosis Transcription Factor NFKB
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- Angel, P., and Herrlich, P. (1994). The Fos and Jun families of transcription factors. In: “CRC-press”, Boca-Raton, FL, U.S.A.Google Scholar
- Deng, H.-X., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W.-Y, Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., Warner, C, Deng, G., Soriano, E., Smyth, C., Parge, H. E., Ahmed, A., Roses, A. D., Hallewell, R. A., Pericak-Vance, M. A., and Siddique, T. (1993). Amyotrophic lateral sclerosis and structural defects in Cu, Zn Superoxide dismutase. Science 261, 1047–1051.PubMedCrossRefGoogle Scholar
- Gilbert, S. F. (1994). Developmental Biology. (Sunderland, MA, U.S.A.: Sinauer Associates), pp. 531–622.Google Scholar
- Molitor, J. A., Ballard, D. W., and Greene, W. C. (1991). ΚB-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation. The New Biol. 3, 987–996.Google Scholar
- Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O’Regan, J. P., Deng, H.-X., Rahmani, Z., Krizus, A., McKenna-Yasek, D., Cayabyab, A., Gaston, S. M., Berger, R., Tanzi, R. E., Halperin, J. J., Herzfeldt, B., Van den Bergh, R., Hung, W.-Y., Bird, T., Deng, G., Mulder, D. W., Smyth, C, Laing, N. G., Soriano, E., Pericak-Vance, M. A., Haines, J., Rouleau, G. A., Gusella, J. S., Horvitz, H. R., and Brown Jr, R. H. (1993). Mutations in Cu/Zn Superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59–62.PubMedCrossRefGoogle Scholar