Biomonitoring Workers Exposed to Arylamines

Application to Hazard Assessment
  • O. Sepai
  • G. Sabbioni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


Arylamines are important intermediates in the production of plastics and polyurethanes. Employees in many factories are subjected to low level chronic exposure to a wide variety, often a mixture, of arylamines. We have developed methods to measure hemoglobin (Hb) adducts of over 30 arylamines. Using these methods we can biomonitor exposure to low levels of these chemicals. Since, in most cases the air monitoring values were below the detection limit, we have used the protein adduct levels to estimate the daily-dose, which was then compared to the daily dose which yields tumors in 50% of rodents (TD50).


Quantitative Structure Activity Relationship Aromatic Amine Breast Implant Adduct Level Hemoglobin Adduct 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • O. Sepai
    • 1
  • G. Sabbioni
    • 2
  1. 1.Department of Environmental and Occupational Medicine The Medical SchoolUniversity of Newcastle upon TyneNewcastleUK
  2. 2.Institut für Toxikologie und PharmakologieUniversität WürzburgWürzburgGermany

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