Human GSH-Transferase in Risk Assessment
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)
Human cytosolic glutathione-S-transferases (GST) are dimeric enzymes which have been classified, mainly by their isoelectric points, into four classes (Brockmöller et al. 1993):
class α (basic, GSTA);
class μ (near-neutral, new GSTM);
class π (acidic, GSTP);
class θ (slightly basic, GSTT).
KeywordsEthylene Oxide Lung Cancer Risk Methyl Bromide Mandelic Acid Styrene Oxide
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Unable to display preview. Download preview PDF.
- Alexandrie, A.K., Sundberg, M.J., Seidegård, J., Tornling, G., Rannug, A., 1994, Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types, Carcinogenesis. 15: 1785–1790.PubMedCrossRefGoogle Scholar
- Goergens, H.W., 1992, Stereochemische Aspekte bei der biologischen Überwachung beruflicher Styrolexpo-sition, Thesis, Universität des Saarlandes, Homburg/Saar, Germany.Google Scholar
- Hallier, E., Schröder, K., Asmuth, K., Dommermuth, A., Aust, B., Goergens, H.W., 1994, Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: Influence of polymorphism of glutathione transferase theta (GSTT1-1). Arch Toxicol 68: 423–427.PubMedCrossRefGoogle Scholar
- Seidergård, J., De Pierre, J.W., Pero, R.W., 1985, Hereditary interindividual differences in the glutathione transferase activity towards trans-stilbene oxide in resting human mononuclear leucocytes are due to a particular isozyme(s), Carcinogenesis 6: 12–1216.Google Scholar
- Thier, R., Föst, U., Deutschmann, S., et al., 1989, Distribution of methylene chloride in humane blood, Arch Toxicol, Suppl. 14: 254–258.Google Scholar
- Thier, R., Taylor, J.B., Pemble, S.E. et al., 1993, Expression of the rat theta class glutathione S-transferase 5-5 in S. typhimurium TA 1535 leads to base-pair mutation upon exposure to dihalomethanes, Biol Chem Hoppe-Seyler 374: 796 (abstract F 105).Google Scholar
© Springer Science+Business Media New York 1996