Species Differences in Metabolism of 1,3-Butadiene
1,3-Butadiene (BD) is a 4-carbon gaseous compound with two double bonds. Used in high tonnage to make styrene-butadiene polymers in the rubber industry, BD is one of the top 20 chemicals in amount manufactured in the USA (Agency of Toxic Substances and Disease Registry, 1992). BD has also been detected in ppb levels in urban air, gasoline exhaust, and cigarette smoke. Because of large amounts used, BD was tested for toxicity in 2-year inhalation exposures of both Sprague-Dawley rats (Owen et al., 1987) and B6C3F1 mice (Huff et al., 1985; Melnick et al, 1990).
KeywordsSpecies Difference Internal Dose Mercapturic Acid Volatile Metabolite B6C3F1 Mouse
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