Species Differences in Metabolism of 1,3-Butadiene

  • Rogene F. Henderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

1,3-Butadiene (BD) is a 4-carbon gaseous compound with two double bonds. Used in high tonnage to make styrene-butadiene polymers in the rubber industry, BD is one of the top 20 chemicals in amount manufactured in the USA (Agency of Toxic Substances and Disease Registry, 1992). BD has also been detected in ppb levels in urban air, gasoline exhaust, and cigarette smoke. Because of large amounts used, BD was tested for toxicity in 2-year inhalation exposures of both Sprague-Dawley rats (Owen et al., 1987) and B6C3F1 mice (Huff et al., 1985; Melnick et al, 1990).

Keywords

Species Difference Internal Dose Mercapturic Acid Volatile Metabolite B6C3F1 Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agency for Toxic Substances and Disease Registry, 1992, Toxicological profile for 1,3-butadiene, TP-91/07, Available NTIS, U.S. Department of Commerce, Springfield, VA, USA.Google Scholar
  2. Bechtold, W. E., Strunk, M. R., Chang, I. Y., Ward, J. B. Jr., and Henderson, R. F. 1994, Species differences in urinary butadiene metabolites: Comparisons of metabolite ratios between mice, rats and humans, Toxicol. Appl. Pharmacol 127: 44–49.PubMedCrossRefGoogle Scholar
  3. Bechtold, W. E., Strunk, M. R., Thornton-Manning, J. R., and Henderson, R. F., 1995, Analysis of butadiene, butadiene monoxide and butadiene dioxide in blood by gas chromatography/gas chromatography/mass spectroscopy, Chem. Res. Toxicol. (in press).Google Scholar
  4. Bond, J. A., Dahl, A. R., Henderson, R. F., Dutcher, J. S., Mauderly, J. L., and Birnbaum, L. S. 1986, Species differences in the disposition of inhaled 1,3-butadiene, Toxicol. Appl. Pharmacol. 84: 617–627.PubMedCrossRefGoogle Scholar
  5. Cochrane, J. E., and Skopek, T. R. 1994, Mutagenicity of butadiene and its epoxide metabolites. I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-l,2-butanediol in cultured human lymphoblasts, Carcinogenesis 15: 713–717.PubMedCrossRefGoogle Scholar
  6. Csanàdy, G. A., Guengerich, F. P., and Bond, J. A. 1992, Comparison of the biotransformation of 1,3-butadiene and its metabolite, 1, 1, 3-butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice, Carcinogenesis 13: 1143–1153.PubMedCrossRefGoogle Scholar
  7. Csanàdy, G. A., Guengerich, F. P., and Bond J. A., 1993, Erratum, Carcinogenesis 14: 784.CrossRefGoogle Scholar
  8. Dahl, A. R., Sun, J. D., Birnbaum, L. S., Bond, J. A., Griffith, W. C. Jr., Mauderly, J. L., Muggenburg, B. A., Sabourin, P. J., and Henderson, R. F. 1991, Toxicokinetics of inhaled 1,3-butadiene in monkeys: Comparison to toxicokinetics in rats and mice, Toxicol. Appl. Pharmacol. 110: 9–19.PubMedCrossRefGoogle Scholar
  9. Himmelstein, M. W., Turner, M. J., Asgharian, B., and Bond, J. A. 1994, Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation, Carcinogenesis 15: 1479–1486.PubMedCrossRefGoogle Scholar
  10. Huff, J. E., Melnick, R. L., Solleveld, H. A., Haseman, J. K., Powers, M., and Miller, R. A., 1985, Multiple organ carcinogenicity of 1,3-butadiene in B6C3F, mice after 60 weeks of inhalation exposure. Science 227: 548–549.PubMedCrossRefGoogle Scholar
  11. Melnick, R. L., Huff, J., Chou, B. J., and Miller, R. 1990, Carcinogenicity of 1,3-butadiene in C57BL/6 C3H F1 mice at low exposure concentrations, Cancer Res. 50: 6592–6599.PubMedGoogle Scholar
  12. Owen, P. E., Glaister, J. R., Gaunt, I. F., and Pullinger, D. H. 1987, Inhalation toxicity studies with 1,3-butadiene. 3. Two-year toxicity/carcinogenicity studies in rats, Am. Ind. Hyg. Assoc. J. 48: 407–413.PubMedCrossRefGoogle Scholar
  13. Sabourin, P. J., Burka, L. T., Bechtold, W. E., Dahl, A. R., Hoover, M. D., Chang, I. Y., and Henderson, R. F. 1992, Species differences in urinary metabolites; identification of l,2-dihydroxy-4-(N-acetylcysteinyl)butane, a novel metabolite of butadiene, Carcinogenesis 13: 1633–1638.PubMedCrossRefGoogle Scholar
  14. Schmidt, U., and Loeser, E. 1986, Epoxidation of 1,3-butadiene in liver and lung tissue of mouse, rat, monkey and man, Adv. Exp. Med. Biol. 197: 951–957.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Rogene F. Henderson
    • 1
  1. 1.Inhalation Toxicology Research InstituteLovelace Biomedical and Environmental Research InstituteAlbuquerqueUSA

Personalised recommendations