Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene

The Use of in Vitro and in Vivo Metabolism, Kinetics and PB-PK Modeling
  • Erna Hissink
  • Ben van Ommen
  • Jan J. Bogaards
  • Peter J. van Bladeren
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


Halogenated benzenes are extensively used as solvents, fumigants and intermediates in the production of pesticides and dyes and therefore represent significant environmental contaminants (Hawley, 1971; US-EPA, 1985). It has been shown that biotransformation is necessary to exhibit toxicity (Brodie et al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may either rearrange to produce phenols, hydrolyse to form dihydrodiols or conjugate with glutathione.


Covalent Binding Glutathione Conjugate Mercapturic Acid Hepatic Glutathione Epoxide Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used






ascorbic acid




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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Erna Hissink
    • 1
  • Ben van Ommen
    • 1
  • Jan J. Bogaards
    • 1
  • Peter J. van Bladeren
    • 1
  1. 1.TNO ToxicologyAJ ZeistThe Netherlands

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