Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene
Halogenated benzenes are extensively used as solvents, fumigants and intermediates in the production of pesticides and dyes and therefore represent significant environmental contaminants (Hawley, 1971; US-EPA, 1985). It has been shown that biotransformation is necessary to exhibit toxicity (Brodie et al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may either rearrange to produce phenols, hydrolyse to form dihydrodiols or conjugate with glutathione.
KeywordsCovalent Binding Glutathione Conjugate Mercapturic Acid Hepatic Glutathione Epoxide Intermediate
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