4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells

  • Wilhelm Stahl
  • Michael Hanusch
  • Helmut Sies
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


Retinoids and carotenoids inhibit the transformation of murine C3H/10T1/2 fibroblasts by chemical and physical carcinogens (Hossain et al., 1989; Pung et al., 1988). The protective ability of carotenoids was reported to be independent of their provitamin A activity and their ability to inhibit lipid peroxidation (Zhang et al., 1991). One of the most active carotenoids is canthaxanthin, which is not a known provitamin A in mammals (Bertram et al., 1991). The inhibitory effect of both retinoids and carotenoids towards neoplastic transformation correlates with their activity to induce gap junctional communication (Zhang et al., 1991; Bertram et al., 1991).


Retinoic Acid Oxidation Fraction Cx43 mRNA Human Intestinal Mucosa Nuclear Retinoic Acid Receptor 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Wilhelm Stahl
    • 1
  • Michael Hanusch
    • 1
  • Helmut Sies
    • 1
  1. 1.Institut für Physiologische Chemie I and Biologisch-Medizinisches ForschungszentrumHeinrich-Heine-Universität DüsseldorfDüsseldorfGermany

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