Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones

  • U. Schmidt
  • G. Schlüter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


The quinolone antibiotic BAY y 3118 is a photochemically labile compound, and irradiation with UV-A light leads to its rapid decomposition. In vivo, following oral drug administration to guinea pigs, irradiation of the animals not only results in a severe local phototoxicity, but also leads to systemic phototoxic reactions [1].


Nalidixic Acid Skin Extract Phototoxic Reaction Oral Drug Administration Toxic Oxygen Radical 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • U. Schmidt
    • 1
  • G. Schlüter
    • 1
  1. 1.FB ToxicologyBAYER AGWuppertalGermany

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