Regulation of the Superoxide Releasing System in Human Fibroblasts
Fibroblasts release low amounts of reactive oxygen intermediates (ROIs) upon contact with appropriate stimuli, which have regulatory functions in inter- and intracellular signal transduction. Ca2+/calmodulin are involved in the activation process of the ROI-generating system. A rise of intracellular Ca2+ is necessary, but not sufficient to trigger the release of ROIs. As a second signal, protein phosphorylation seems to be involved in the activation process.
KeywordsHuman Fibroblast Platelet Activate Factor Okadaic Acid Intracellular Signal Transduction Reactive Oxygen Intermediate
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