Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Liver
Pivalic acid (PIV) or trimethylacetic acid is a compound thought to be harmless and widely used for pro-drug production, such as pivampicillin and pivaloyloxymethyl dopa ester (Binderup et al. 1971, Wickers et al. 1985). These pro-drugs administrated to rat and monkey undergo an hydrolysis releasing free PIV, which is excreted in urine mostly unchanged or as carnitine or glucuronic acid conjugates.
KeywordsValproic Acid Mitochondrial Fraction Sodium Valproate Mercapturic Acid Selective Depletion
Unable to display preview. Download preview PDF.
- Bélanger, P.M., Desgagné, M. and Bruguerolle, B. (1991). Temporal variations in microsomal lipid peroxidation and glutathione concentration of rat liver. Drug Metabol. Dipos. 19: 241–244.Google Scholar
- Kassahun, K., Farrel, K. and Abbot, F. (1991). Identification and characterization of the glutathionc and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, a toxic, in rat and humans. Drug Metabol. Dispos. 19: 525–535.Google Scholar
- Meredith, M.J. and Reed, D.J. (1982). Status of the mitochondrial pool of glutathione in the isolated hepatocytes. J. Biol: Chem. 257: 3747–3753.Google Scholar