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NMR Methods in Studies of Brain Ischemia

  • Lee-Hong Chang
  • Thomas L. James
Part of the Biological Magnetic Resonance book series (BIMR, volume 11)

Abstract

In vivo NMR spectroscopy has gained world-wide attention since the publication of the use of surface coils to noninvasively observe metabolic changes in whole animals (Ackerman et al., 1980). It has provided an attractive method for continuously monitoring metabolic changes in short time intervals in the physiological and pathophysiological states of an organ or a tissue of an individual animal (Shulman, 1979; Gadian, 1982; James and Margulis, 1984; Radda, 1986; Cohen, 1987). Due to relatively low sensitivity, NMR methods detect only those metabolites whose concentrations are ≥ 1.0 mM and that are not tightly bound to macromolecules or immobile cellular structures. A large number of NMR-observable nuclei have been used as naturally occurring or artificial probes for in vivo studies.

Keywords

Pulse Sequence Brain Ischemia Surface Coil Spectroscopic Imaging Sensitive Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackerman, J. J. H., Grove, T. H., Wong, G. G., Gadian, D. G., and Radda, G. K., 1980, Nature 283:167.PubMedCrossRefGoogle Scholar
  2. Ackerman, J. J. H., Ewy, C. S., Becker, N. N., and Shalowitz, R. A., 1987, Proc. Natl. Acad. Sci. USA 84:4099.CrossRefGoogle Scholar
  3. Agris, P. F., and Campbell, I. D., 1982, Science 216: 1325.PubMedCrossRefGoogle Scholar
  4. Aue, W. P., 1986, Rev. Magn. Reson. Med. 1: 21.Google Scholar
  5. Avison, M. J., Hetherington, H. P., and Shulman, R. G., 1986, Annu. Rev. Biophys. Biophys. Chem. 15: 377.PubMedCrossRefGoogle Scholar
  6. Bailey, I. A., Williams, S. R., Radda, G. K., and Gadian, D. G., 1981, Biochem. J. 196: 171.PubMedGoogle Scholar
  7. Balaban, R. S., Koretsky, A. P., and Katz, L. A., 1986, J. Magn. Reson. 68: 556.CrossRefGoogle Scholar
  8. Behar, K. L., Rothman, D. L., Shulman, R. G., Petroff, O. A. C., and Prichard, J. W., 1984, Proc. Natl. Acad. Sci. USA 81: 2517.PubMedCrossRefGoogle Scholar
  9. Bendati, M. R., and Pegg, D. T., 1986, J. Magn. Reson. 67: 376.CrossRefGoogle Scholar
  10. Bendall, M. R., Connelly, A., and McKendry, J. M., 1986, Magn. Reson. Med. 3: 157PubMedCrossRefGoogle Scholar
  11. Berkowitz, B. A., Wolff, S. D., and Balaban, R. S., 1988, J. Magn. Reson. 79: 547CrossRefGoogle Scholar
  12. Birken, D. L., and Oldenforf, W. H., 1989, Neurosci. Biobehay. Rev. 13: 23.CrossRefGoogle Scholar
  13. Blondet, P., Decorps, M., Confort, S., and Albrand, J. P., 1987, J. Magn. Reson. 75: 434.CrossRefGoogle Scholar
  14. Bolinger, L., Seeholzer, S., Kofron, J., and Leigh, J. S., 1987, private communication. Bottomley, P. A., 1989, Radiology 170: 1.Google Scholar
  15. Bottomley, P. A., Charles, H. C., Roemer, P. B., Flamig, D., Engeseth, H., Edelstein, W. A., and Mueller, O. M., 1988, Magn. Reson. Med. 7: 319.PubMedCrossRefGoogle Scholar
  16. Bottomley, P. A., Hardy, C. J., Roemer, P. B., and Mueller, O. M., 1989, Magn. Reson. Med. 12: 348.PubMedCrossRefGoogle Scholar
  17. Brant-Zawadzki, M., Bartkowski, H. M., Ortendahl, D. A., Pitts, L. H., Hylton, N. M., Nishimura, M. C., and Crooks, L. E., 1984, Am. J. Neuroradiology 5: 125Google Scholar
  18. Brindle, K. M., Porteous, R., and Campbell, J., 1984, J. Magn. Reson. 56: 543.CrossRefGoogle Scholar
  19. Brown, F. F., Campbell, I. D., Kchel, P. W., and Rabenstein, D. L., 1977, FEBS Lett. 82: 12PubMedCrossRefGoogle Scholar
  20. Brown, T. R., Kincaid, B. M., and Ugurbil, K., 1982, Proc. Natl. Acad. Sci. USA 79: 3523.PubMedCrossRefGoogle Scholar
  21. Brown, T. R., Buchtal, S. D., Murphy-Boesch, J., Nelson, S. J., and Taylor, J. S., 1989, J. Magn. Reson. 82: 629.CrossRefGoogle Scholar
  22. Bruhn, H., Frahm, J., Gyngell, M. L., Merboldt, K. D., Hanicke, W., and Sauter, R., 1989, Magn. Reson. Med. 5: 126.CrossRefGoogle Scholar
  23. Campbell, I. D., Dobson, C. M., Williams, R. J. P., and Xavier, A. V., 1973, J. Magn. Reson. 11: 172.CrossRefGoogle Scholar
  24. Campbell, I. D., Dobson, C. M., Williams, R. J. P., and Wright, P. F., 1974, FEBS Lett. 57: 96.CrossRefGoogle Scholar
  25. Chang, L.-H., Chew, W. M., Weinstein, P. R., and James, T. L., 1987a,1 Magn. Reson. 72:168.Google Scholar
  26. Chang, L.-H., Pereira, B. M., Weinstein, P. R., Keniry, M. A., Murphy-Boesch, J., Litt, L., and James, T. L., 1987b, Magn. Reson. Med. 4: 575.PubMedCrossRefGoogle Scholar
  27. Chang, L.-H., Cohen, Y., Weinstein, P. R., Chileuitt, L., and James, T. L., 1990a, Magn. Reson. Imag., 9: 223.CrossRefGoogle Scholar
  28. Chang, L.-H., Shirane, R., Weinstein, P. R., and James, T. L., 1990b, Magn. Reson. Med. 13: 6.PubMedCrossRefGoogle Scholar
  29. Choi, D. W., and Rothman, S. M., 1990, Annu. Rev. Neurosci. 13: 171.PubMedCrossRefGoogle Scholar
  30. Cohen, S. M., (ed.), 1987, Physiological NMR Spectroscopy: From Isolated Cells to Man, Ann. N.Y. Acad. Sci. 508.Google Scholar
  31. Cohen, S. M., Ogawa, S., Rottenberg, H., Glynn, P., Yamane, T., and Shulman, R. G., 1978, Nature 273: 554.PubMedCrossRefGoogle Scholar
  32. Cohen, Y., Chang, L.-H., Litt, L., and James, T. L., 1989, J. Magn. Reson. 85: 203.CrossRefGoogle Scholar
  33. Cohen, Y., Chang, L.-H., Litt, L., Kim, F., Severinghaus, J. W., Weinstein, P. R., Davis, R. L., Germano, I., and James, T. L., 1990a, J. Cereb. Blood Flow Metab. 10: 277.PubMedCrossRefGoogle Scholar
  34. Cohen, Y., Sanada, T., Pitts, L. H., Chang, L.-H., Nishimura, M. C., Weinstein, P. R., Litt, L., and James, T. L., 1990b, Magn. Reson. Med. 17: 225.CrossRefGoogle Scholar
  35. Corbett, R. J., Laptook, A. R., Hassan, A., and Nunnally, R.-L., 1988, Magn. Reson. Med. 6: 99.PubMedCrossRefGoogle Scholar
  36. Crockard, H. A., Gadian, D. G., Frackowiak, R. S., Proctor, E., Allen, K., Williams, S. R., and Ross-Russell, R. W., 1987, J. Cereb. Blood Flow Metab. 7: 394.PubMedCrossRefGoogle Scholar
  37. De Graaf, A. A., Bovee, W. M. M. J., Deutz, N. E. P., and Chamuleau, R. A. F. M., 1988, Magn. Reson. Imag. 6: 255.CrossRefGoogle Scholar
  38. Derby, K., Hawryszko, C., and Tropp, J., 1989, Magn. Reson. Med. 12: 235.PubMedCrossRefGoogle Scholar
  39. Deutch, C. J., and Taylor, J. S., 1987, Ann. N.Y. Acad. Sci. 508: 33.CrossRefGoogle Scholar
  40. Doddrell, D. M., Brereton, I. M., Moxon, L. N., and Garroway, G. J., 1989, Magn. Reson. Med. 9:132.Google Scholar
  41. Edelstein, W. A., Hardy, C. J., and Mueller, O. M., 1986, J. Magn. Reson. 67: 156.CrossRefGoogle Scholar
  42. Edzes, H. T., Zuurbier, C. J., Huijing, P. A., and Bulthuis, J., 1990, J. Magn. Reson. 87: 395.CrossRefGoogle Scholar
  43. Elefl, S. M., Schnall, M. D., Ligetti, L., Osbakken, M., Subramanian, V. H., Chance, B., and Leigh, J. S., 1988, Magn. Reson. Med. 7: 412.CrossRefGoogle Scholar
  44. Ernst, R., 1966, Adv. Magn. Reson. 2: 1.Google Scholar
  45. Evelhoch, J. L., Ewy, C. S., Siegfried, B. A., and Ackerman, J. J. H., 1985, Magn. Reson. Med. 2: 410.PubMedCrossRefGoogle Scholar
  46. Ewing, J. R., Branch, C. A., Helpern, J. A., Smith, M. B., Butt, S. M., and Welch, K. M. A., 1989, Stroke 20: 259.PubMedCrossRefGoogle Scholar
  47. Frahm, J., Buhn, H., Gyngell, M. L., Merboldt, K. D., Hanicke, W., and Sauter, R., 1989, Magn. Reson. Med. 11:47.Google Scholar
  48. Freeman, D., Barker, P. B., Parivar, F., Benninghoven, S., Jones, L. W., Moress, E. A., and Ross, B., 1989, Transplantation 48: 202.PubMedCrossRefGoogle Scholar
  49. Fukushima, E., and Roeder, S. B. W., 1981, Experimental Pulse NMR: A Nuts and Bolts Approach, Addison-Wesley, Reading, Mass.Google Scholar
  50. Gadian, D. G., 1982, NMR and Its Applications to Living Systems, Oxford University Press, London.Google Scholar
  51. Gadian, D. G., and Robinson, F. N. H., 1979, J. Magn. Reson. 34: 449.CrossRefGoogle Scholar
  52. Gadian, D. G., Proctor, E., Williams, S. R., Cady, E. B., and Gardiner, R. M., 1986, Magn. Reson. Med. 3: 150.PubMedCrossRefGoogle Scholar
  53. Garcia, J. C., 1984, Stroke 15: 5.PubMedCrossRefGoogle Scholar
  54. Garwood, M., Schleich, T., Matson, G. B., and Acosta, G., 1984, J. Magn. Reson. 60: 268.CrossRefGoogle Scholar
  55. Gonnella, N. C., and Silverman, R. F., 1989, J. Magn. Reson. 85: 24.CrossRefGoogle Scholar
  56. Gonzalez-Mendez, R., Litt, L., Koretsky, A. P., Von Colditz, J., Weiner, M. W., and James, T. L., 1984, J. Magn. Reson. 57: 526.CrossRefGoogle Scholar
  57. Gonzalez-Mendez, R., Moseley, M. E., Murphy-Boesch, J., Chew, W. M., Litt, L., and James, T. L., 1985, J. Magn. Reson. 65: 516.CrossRefGoogle Scholar
  58. Graham, D. I., 1988, J. Cereb. Blood Flow Metab. 8: 769.PubMedCrossRefGoogle Scholar
  59. Gupta, R. K., and Moore, R. D., 1980, J. Biol. Chem. 255: 3987.PubMedGoogle Scholar
  60. Gupta, R. K., and Yushok, W. D., 1980, Proc. Natl. Acad. Sci. USA 77: 2487.PubMedCrossRefGoogle Scholar
  61. Gyulai, L., Schnall, M., McLaughlin, A. C., Leigh, J. S., and Chance, B., 1987, J. Cereb. Blood Flow Metab. 7: 543.PubMedCrossRefGoogle Scholar
  62. Hardy, C. J., and Dumoulin, C. L., 1987, Magn. Reson. Med. 5: 58.PubMedCrossRefGoogle Scholar
  63. Hardy, C. J., Edelstein, W. A., and Vatis, D., 1986, J. Magn. Reson. 66: 470.CrossRefGoogle Scholar
  64. Haselgrove, J. C., Subramanian, V. H., Leigh, J. S., Gyulai, L., and Chance, B., 1983, Science 220: 1170.PubMedCrossRefGoogle Scholar
  65. Hetherington, H. P., Avison, M. J., and Shulman, R. G., 1985, Proc. Natl. Acad. Sci. USA 82: 3115.PubMedCrossRefGoogle Scholar
  66. Hetherington, H. P., Wishart, D., Fitzpatrick, S. M., Cole, P., and Shulman, R. G., 1986, J. Magn. Reson. 66: 313.CrossRefGoogle Scholar
  67. Hore, P. J., 1983, J. Magn. Reson. 55: 283.CrossRefGoogle Scholar
  68. Hore, P. J., 1989, Methods Enzymol. 176: 64.PubMedCrossRefGoogle Scholar
  69. Hoult, D. I., 1979, J. Magn. Reson. 33: 183.CrossRefGoogle Scholar
  70. Hoult, D. I., and Lauterbur, P. C., 1979, J. Magn. Reson. 34: 425.CrossRefGoogle Scholar
  71. Hoult, D. I., and Richards, R. E., 1976, J. Magn. Reson. 24: 71.Google Scholar
  72. Hyde, J. S., Jesmanowicz, A., Froncisz, W., Kneeland, J. B., and Grist, T. M., 1986, J. Magn. Reson. 70: 512.CrossRefGoogle Scholar
  73. James, T. L., and Margulis, A. R., (eds.), 1984, Biomedical Magnetic Resonance, Radiology Research and Education Foundation, San Francisco.Google Scholar
  74. James, T. L., and Matson, G. B., 1979, J. Magn. Reson. 33: 345.CrossRefGoogle Scholar
  75. James, T. L., Matson, G. B., and Kuntz, I. D., 1978, J. Am. Chem. Soc. 100: 3590.CrossRefGoogle Scholar
  76. Karczmar, G. S., Tavares, N. J., and Moseley, M. E., 1989, Radiology 172: 363.PubMedGoogle Scholar
  77. Karlsson, B. R., and Steen, P. A., 1989, J. Neurosurg. Anesthesiol. 1: 278.PubMedCrossRefGoogle Scholar
  78. Knüttel, A., and Kimich, R., 1989, Magn. Reson. Med. 10: 404.PubMedCrossRefGoogle Scholar
  79. Kumar, A., Welti, D., and Ernst, R., 1975, J. Magn. Reson. 18: 69.CrossRefGoogle Scholar
  80. Le Bihan, D., Breton, E., Lallemand, D., Aubin, M. L., and Vignaud, J., 1988, Radiology 168: 497.PubMedGoogle Scholar
  81. Ligeti, L., Osbakken, M. D., Subramanian, H. V., Kovach, A. G. B., Leigh, J. S., and Chance, B., 1987, Magn. Reson. Med. 4: 441.PubMedCrossRefGoogle Scholar
  82. Lohman, J. A. B., and Bulthuis, J., 1985, J. Magn. Reson. 63: 593.CrossRefGoogle Scholar
  83. Longa, E. Z., Weinstein, P. R., Carlson, S., and Cummins, R., 1989, Stroke 20: 84.PubMedCrossRefGoogle Scholar
  84. Mansfield, P., and Chapman, B., 1986, J. Magn. Reson. 66: 573.CrossRefGoogle Scholar
  85. Matson, G. B., and Weiner, M. W., 1988, in Magnetic Resonance Imaging (Stark, D. D., and Bradley, W. G., eds.), Mosby, St. Louis, p. 201.Google Scholar
  86. Meier, J. E., and Marshall, A. G., 1990, in Biological Magnetic Resonance (Berliner, L. J., and Reuben, J., eds.), Plenum Press, New York, p. 199.Google Scholar
  87. Moon, R. B., and Richards, J. H., 1973, J. Biol. Chem. 248: 7276.PubMedGoogle Scholar
  88. Moonen, C., Oberhaensli, R., Galloway, G., Rajagopalan, B., and Radda, G., 1985, Clin. Sci. 68 (Suppl. 2): 29.Google Scholar
  89. Moseley, M. E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M. F., and Weinstein, P. R., 1990, Magn. Reson. Med. 14: 330.PubMedCrossRefGoogle Scholar
  90. Müller, S., and Seelig, J., 1987, J. Magn. Reson. 72: 456.CrossRefGoogle Scholar
  91. Murphy, E. J., Rajagopalan, B., Brindle, K., and Radda, G. K., 1989, Magn. Reson. Med. 12: 282.PubMedCrossRefGoogle Scholar
  92. Murphy-Boesch, J., 1984, in Biomedical Magnetic Resonance (James, T. L., and Margulis, A. R., eds.), Radiology Research and Education Foundation, San Francisco, p. 47.Google Scholar
  93. Murphy-Boesch, J., and Koretsky, A. P., 1983, J. Magn. Reson. 54: 526.CrossRefGoogle Scholar
  94. Navon, G., Ogawa, S., Shulman, R. G., and Yamane, T., 1977, Proc. Natl. Acad. Sci. USA 74: 87.PubMedCrossRefGoogle Scholar
  95. Navon, G., Shulman, R. G., Yamane, T., Eccleshall, T. R., and Lam, K. B., 1979, Biochemistry 18: 4487.PubMedCrossRefGoogle Scholar
  96. Nosel, W., Trimble, L. A., Shen, J. F., and Allen, P. S., 1989, Magn. Reson. Med. 11: 398PubMedCrossRefGoogle Scholar
  97. Pan, J. W., Hamm, J. R., Rothman, D. L., and Shulman, R. G., 1988, Proc. Natl. Acad. Sci. USA 85: 7836.PubMedCrossRefGoogle Scholar
  98. Petroff, O. A. C., Prichard, J. W., Behar, K. L., Alger, J. R., den Hollander, J. A., and Shulman, R. G., 1985a, Neurology 35: 781.PubMedCrossRefGoogle Scholar
  99. Petroff, O. A. C., Prichard, J. W., Behar, K. L., Rothman, D. L., Alger, J. R., and Shulman, R. G., 1985b, Neurology 35: 1681.PubMedCrossRefGoogle Scholar
  100. Petroff, O. A. C., Ogino, T., and Alger, J. R., 1988, J. Neurochem. 51: 163.PubMedCrossRefGoogle Scholar
  101. Pettegrew, J. W., 1990, NMR: Principles and Applications to Biomedical Research, Springer-Verlag, Berlin.CrossRefGoogle Scholar
  102. Pettegrew, J. W., Withers, G., Panchalingam, K., and Post, J. F. M., 1988, Magn. Reson. Imag. 6: 135.CrossRefGoogle Scholar
  103. Prichard, J. W., and Shulman, R. G., 1986, Annu. Rev. Neurosci. 9: 61.PubMedCrossRefGoogle Scholar
  104. Rabenstein, D. L., and Isab, A. A., 1982, Anal. Biochem. 121: 423.PubMedCrossRefGoogle Scholar
  105. Radda, G. K., 1986, Science 233: 640.PubMedCrossRefGoogle Scholar
  106. Roemer, P. B., Edelstein, W. A., Hayes, C. E., Souza, S. P., and Mueller, O. M., 1990, Magn. Reson. Med., 16: 192.PubMedCrossRefGoogle Scholar
  107. Roth, K., Hubesch, B., Meyerhoff, D. J., Naruse, S., Gober, J. R., Lawry, T. J., Boska, M. D., Matson, G. B., and Weiner, M. W., 1989, J. Magn. Reson. 81: 299.CrossRefGoogle Scholar
  108. Rothman, D. L., Arias-Mendoza, F., Shulman, G. I., and Shulman, R. G., 1984a, J. Magn. Reson. 60: 430.CrossRefGoogle Scholar
  109. Rothman, D. L., Behar, K. L., Hetherington, H. P., and Shulman, R. G., 1984b, Proc. Natl. Acad. Sci. USA 81: 6330.PubMedCrossRefGoogle Scholar
  110. Rothman, D. L., Behar, K. L., Hetherington, H. P., den Hollander, J. A., Benda11, M. R., Petroff, O. A. C., and Shulman, R. G., Proc. Natl. Acad. Sci. USA 82: 1633.Google Scholar
  111. Schnall, M. D., Subramanian, V. H., Leigh, J. S., and Chance, B., 1985, J. Magn. Reson. 65: 122.CrossRefGoogle Scholar
  112. Schnall, M. D., Yoshizake, K., Chance, B., and Leigh, J. S., 1988, Magn. Reson. Med. 6: 15.PubMedCrossRefGoogle Scholar
  113. Seo, Y., Murakami, H., Watari, Y., Imai, Y., Yoshizaki, K., Nishikawa, H., and Morimoto, T., 1983, J. Biochem. 94: 729.PubMedGoogle Scholar
  114. Shulman, R. G., 1979, Biological Applications of Magnetic Resonance, Academic Press, New York.Google Scholar
  115. Siesjö, B. K., and Wieloch, T., 1985, Br. J. Anaesth. 57: 47.PubMedCrossRefGoogle Scholar
  116. Silver, M. S., Joseph, R. I., and Hoult, D. I., 1984, J. Magn. Reson. 59: 347.CrossRefGoogle Scholar
  117. Smith, G. A., Hesketh, R. T., Metcalfe, J. C., Feeney, J., and Morris, P. K., 1983, Proc. Natl. Acad. Sci. USA 80: 7178.PubMedCrossRefGoogle Scholar
  118. Sotak, C. H., and Freeman, D. M., 1988, J. Magn. Reson. 77: 382.CrossRefGoogle Scholar
  119. Sotak, C. H., Freeman, D. M., and Hurd, R. E., 1988, J. Magn. Reson. 78: 355.CrossRefGoogle Scholar
  120. Springer, C. S., 1987, Annu. Rev. Biophys. Biophys. Chem. 16: 375.PubMedCrossRefGoogle Scholar
  121. Stromski, M. E., Arias-Mendoza, F., Alger, J. R., and Shulman, R. G., 1986, Magn. Reson. Med. 3: 24.PubMedCrossRefGoogle Scholar
  122. Stryjewski, D., Oschkinat, H., and Leibfritz, D., 1990, Magn. Reson. Med. 13: 158.PubMedCrossRefGoogle Scholar
  123. Taylor, D. J., Bore, P. J., Styles, P., Gadian, D. G., and Radda, G. K., 1983, Mol. Biol. Med. 1: 77.PubMedGoogle Scholar
  124. Thulborn, K. R., and Ackerman, J. J. H., 1983, J. Magn. Reson. 55: 357.CrossRefGoogle Scholar
  125. Twieg, D. B., Meyerhoff, D. J., Hubesch, B., Roth, K., Sappey-Marinier, D., Boska, M. D., Gober, J. R., Schaefer, S., and Weiner, M. W., 1989, Magn. Reson. Med. 12: 291.PubMedCrossRefGoogle Scholar
  126. Tycko, R., Cho, H. M., Schneider, E., and Pines, A., 1985, J. Magn. Reson. 61: 90.CrossRefGoogle Scholar
  127. Ugurbil, K., Garwood, M., and Rath, A., 1988, J. Magn. Reson. 80: 448.CrossRefGoogle Scholar
  128. Villringer, A., Rosen, B. R., Belliveau, J. W., Ackerman, J. L., Lauffer, R. B., Buxton, R. B., Chao, Y. S., Wedeen, V. J., and Brady, T. J., 1988, Magn. Reson. Med. 6: 164.PubMedCrossRefGoogle Scholar
  129. Warner, D. S., 1989, J. Neurosurg. Anesthesiot. 1: 290.CrossRefGoogle Scholar
  130. Williams, S. R., and Gadian, D. G., 1986, Q. J. Exp. Physiol. 71: 335.PubMedGoogle Scholar
  131. Williams, S. R., Gadian, D. G., Proctor, E., Sprague, D. B., Talbot, D. G., Young, I. R., and Brown, F. F., 1985, J. Magn. Reson. 63: 406.CrossRefGoogle Scholar
  132. Williams, S. R., Gadian, D. G., and Proctor, E., 1986, J. Magn. Reson. 66: 562.CrossRefGoogle Scholar
  133. Williams, S. R., Proctor, E., Allen, K., Gadian, D. G., and Crockard, H. A., 1988, Magn. Reson. Med. 7: 425.PubMedCrossRefGoogle Scholar
  134. Yoshizaki, K., Seo, Y., and Nishikawa, H., 1981, Biochim. Biophys. Acta 678: 283.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Lee-Hong Chang
    • 1
  • Thomas L. James
    • 2
  1. 1.Department of Pharmaceutical ChemistryUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Pharmaceutical Chemistry and Department of RadiologyUniversity of CaliforniaSan FranciscoUSA

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