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NMR Methods in Studies of Brain Ischemia

  • Chapter
In Vivo Spectroscopy

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 11))

Abstract

In vivo NMR spectroscopy has gained world-wide attention since the publication of the use of surface coils to noninvasively observe metabolic changes in whole animals (Ackerman et al., 1980). It has provided an attractive method for continuously monitoring metabolic changes in short time intervals in the physiological and pathophysiological states of an organ or a tissue of an individual animal (Shulman, 1979; Gadian, 1982; James and Margulis, 1984; Radda, 1986; Cohen, 1987). Due to relatively low sensitivity, NMR methods detect only those metabolites whose concentrations are ≥ 1.0 mM and that are not tightly bound to macromolecules or immobile cellular structures. A large number of NMR-observable nuclei have been used as naturally occurring or artificial probes for in vivo studies.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of California, San Francisco, California, 94143, USA

    Lee-Hong Chang

  2. Department of Pharmaceutical Chemistry and Department of Radiology, University of California, San Francisco, California, 94143, USA

    Thomas L. James

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  1. Lee-Hong Chang
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  1. Department of Chemistry, The Ohio State University, 43210, Columbus, Ohio, USA

    Lawrence J. Berliner

  2. Research Center, Hercules Incorporated, Wilmington, Delaware, USA

    Jacques Reuben

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Chang, LH., James, T.L. (1992). NMR Methods in Studies of Brain Ischemia. In: Berliner, L.J., Reuben, J. (eds) In Vivo Spectroscopy. Biological Magnetic Resonance, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9477-9_3

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