Computer Simulation of Arterial Blood Flow

Vessel Diseases Under the Aspect of Local Haemodynamics
  • K. Perktold
  • G. Rappitsch


Since the late sixties it has been increasingly accepted that haemodynamic factors are of importance in the initiation and development of atherosclerotic lesions, and the role of blood flow dynamics as a localizing factor in the genesis of atherosclerosis has provided considerable impetus for the investigation of arterial flow phenomena during the last two decades. Clinical observations have proven that atherosclerosis, a disease of large and medium size arteries, has a pattern which is of a local nature whereby regions of branchings and of sharp curvatures are sites of enhanced predilection. From the fluid dynamical point of view these are zones where the flow is highly disturbed. Because of the influence of the geometry on the detailed characteristics of the pattern of blood flow in arteries, the focal nature of atherosclerosis and its relationship to vessel geometry provides indirect evidence for a role of blood flow in the development of the disease. The vascular geometry may be a risk factor (Friedman et al., 1983, Nerem, 1984), one which could be genetically passed on from one generation to the next, and thus, could be a part of the family history of a human being.


Wall Shear Stress Pulsatile Flow Arterial Blood Flow Secondary Motion Curve Tube 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • K. Perktold
    • 1
  • G. Rappitsch
    • 1
  1. 1.Institute of MathematicsTechnical University GrazGrazAustria

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