Interactive Effects of Multiple Mycotoxin Contamination of Swine Diets

  • M. T. Coffey
  • W. M. HaglerJr.
  • E. E. Jones
  • J. M. Cullen
Part of the Biodeterioration Research book series (BIOR, volume 3)

Abstract

Mycotoxin contamination in grains and feedstuffs is a serious agricultural and public health problem. Mycotoxins are causative agents in numerous disease syndromes in swine (Hesseltine, 1979). Over 200 mycotoxins have been identified but relatively few have been confirmed in mycotoxicoses (Tuite, 1979). Aflatoxin B1 (AFB1), which is produced by the fungal genus Aspergillus. has been studied the most extensively. Species of the genus Fusarium that produce zearalenone (ZE) and trichothecene toxins (T-2 toxin and deoxynivalenol) are common in many plant materials. At the present time, even a cursory examination of the scientific literature leads to the conclusion that mycotoxins from these two genera are responsible for most of the adverse effects on swine production. Subacute exposure of swine to these toxins adversely affects health, growth, and reproduction (Hintz et al., 1967; Christensen et al., 1972; Chang et al., 1979), all of which are important determinants of profitability.

Keywords

Average Daily Gain Growth Depression Mycotoxin Contamination Swine Production Trichothecene Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allcroft, R. and Carnaghan, R.B.A. (1963). Groundnut toxicity: An examination for toxin in human food products from animals fed toxic groundnut meal. Vet. Rec., 75, 259–263.Google Scholar
  2. AOAC. (1984). Official Methods of Analysis (14th Ed.). Association of Official Analytical Chemists. Arlington, VA.Google Scholar
  3. Babadoost, M., Hagler, W.M., Jr., Bowman, D.T., and Nelson, P.E. (1987). Field contamination of sorghum with zearalenone and deoxynivalenol: Density segregation to remove mycotoxins, In: Biodeterioration Research I, pp. 99–109 (G.C. Llewellyn and C.E. O’Rear, eds.), Plenum Publishing Corp., N.Y.CrossRefGoogle Scholar
  4. Boyd, P.A. and Wittliff, J.L. (1978). Mechanism of Fusarium mycotoxin action in mammary gland. J. Toxicol. Environ. Health. 4, 1–8.CrossRefGoogle Scholar
  5. Bucolo, G. and David, H. (1973). Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem., 19, 476–482.Google Scholar
  6. Carnaghan, R.B.A. and Crawford, M. (1964). Relationship between ingestion of aflatoxin and primary liver cancer. Brit. Vet. J., 120, 201–204.Google Scholar
  7. Catignani, G.L. and Bieri, J.G. (1983). Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography. Clin. Chem., 29, 708–712.Google Scholar
  8. Chaney, A.L. and Marbach, E.P. (1962). Modified reagents for determination of urea and ammonia. Clin. Chem., 8, 130–132.Google Scholar
  9. Chang, K., Kurtz, H.J., Mirocha, C.J. (1979). Effects of the mycotoxin zearalenone on swine production. Amer. J. Vet. Res., 40, 1260–1267.Google Scholar
  10. Christensen, C.M., Mirocha, C.J., Nelson, G.H., and Quast, J.F. (1972). Effect on young swine of consumption of rations containing corn invaded by Fusarium roseum. Appl. Microbiol., 23, 202.Google Scholar
  11. Coffey, M.T., Hagler, W.M., Jr., and Behlow, R.F. (1985). Effect of dietary protein and fat on the response of weanling pigs to mycotoxin contaminated corn. J. Anim. Sci., 61 (Suppl. 1), 306.Google Scholar
  12. Coffey, M.T., Hagler, W.M., Jr., and Cullen, J.M. (1987). The effect of L-lysine and DL-methionine supplementation on the response of weanling pigs to mycotoxin contaminated corn. J. Anim. Sci., 65 (Suppl. 1), 32.Google Scholar
  13. Coffey, M.T. and Jones, E.E. (1985). Effects of dietary protein level for weanling pigs and subsequent performance to 23 kg. J. Anim. Sci., 61 (Suppl. 1), 306.Google Scholar
  14. •Côté, L.M., Beasley, V.R., Bratich, P.M., Swanson, S.P., Shivaprasad, H.L., and Buck, W.B. (1985). Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. J. Anim. Sci., 61, 942–950.Google Scholar
  15. Duthie, I.F., Lancaster, M.C., Taylor, J., Lomax, E.B., and Clarkson, H.M. (1968). Toxic groundnut meal in feeds for pigs Part II.-The effect of consuming toxic groundnut meal during part of the growing period or during the finishing period. Vet. Rec., 82, 427–430.Google Scholar
  16. Edds, G.T. (1979). Biological effects of aflatoxins in swine, In: Proc. Sym. Interactions of Mycotoxins in Animal Production, pp. 67–76, National Academy of Sciences, Washington, D.C.Google Scholar
  17. Hagler, W.M., Jr. and Behlow, R.F. (1984). Multiple mycotoxin contamination of feedstuffs. 6th Internat. Biodeterio. Soc., Mycotoxin Symposium. Abstr. 48, p.77.Google Scholar
  18. Hagler, W.M., Jr. and Mirocha C.J. (1980). Biosynthesis of (C-14)-zearalenone from 1-(C-14)-acetate by Fusarium roseum ‘Gibbosum’. Appl. Environ. Microbiol., 39, 668–670.Google Scholar
  19. Hagler, W.M., Jr., Mirocha, C.J., and Pathre, S.V. (1981). Biosynthesis of radiolabeled T-2 toxin by Fusarium tricineturn. Appl. Environ. Microbiol., 41, 1049–1051.Google Scholar
  20. Hagler, W.M., Jr., Swanson, S.P., and Bowman, D.T. (1983). Mycotoxins in North Carolina grain sorghum at harvest. Amer. Soc. Microbiol., Abstr. 047, 247.Google Scholar
  21. Hagler, W.M., Jr., Tyczkowska, K., and Hamilton, P.B. (1984). Simultaneous occurrence of deoxynivalenol, zearalenone, and aflatoxin in 1982 scabby wheat from the Midwestern United States. Appl. Environ. Microbiol., 47, 151–154.Google Scholar
  22. Hamilton, P.B. (1977). Interrelationships of mycotoxins with nutrition. Fed. Proc., 36, 1899–1902.Google Scholar
  23. Hamilton, P.B., Tung, H.-T., Harris, J.R., Gainer, J.H., and Donaldson, W.E. (1972). The effect of dietary fat on aflatoxicosis in turkeys. Poul. Sci., 51, 165–170.CrossRefGoogle Scholar
  24. Hesseltine, C.W. (1979). Introduction, definition, and history of mycotoxins of importance to animal production, In: Interactions of Mycotoxins in Animal Production, pp. 3–18, National Academy of Sciences, Washington, D.C.Google Scholar
  25. Hintz, H.F., Booth, A.N., Cucullu, A.F., Gardner, H.K., and Heitman, H., Jr. (1967). Aflatoxin toxicity in swine. Proc. Soc. Exp. Biol. Med., 124, 266–268.CrossRefGoogle Scholar
  26. Hutchins, J.E. Y.J. Lee, K. Tyczkowska, and W.M. Hagler, Jr. (1988). Evaluation of silica cartridge purification and hemiacetal formation for liquid Chromatographic determination of aflatoxins in corn. Arch. Environ. Contam. Toxicol. 18, 319–326.CrossRefGoogle Scholar
  27. Jones, E.E. (1985). Control of early weaning diarrhea in pigs with a new liquid feeding system. J. Anim. Sci., 61 (Suppl. 1), 25.Google Scholar
  28. Klang, D.T., Kennedy, B.J., Pathre, S.V., and Mirocha, C.J. (1978). Binding characteristics of zearalenone analogs to estrogen receptors. Cancer Res., 38, 3611–3615.Google Scholar
  29. Lowrey, O.H., Rosebrough, N.J., Farr, A.L., and Randal, R.J. (1951). Protein measurements with the Folinphenol reagent. J. Biol. Chem., 193, 265–275.Google Scholar
  30. McMillian, W.W., Wilson, D.M., Mirocha, C.J., and Widstrom, N.W. (1983). Mycotoxin contamination in grain sorghum from fields in Georgia and Mississippi. Cereal Chem., 60, 226–227.Google Scholar
  31. Mirocha, C.J., Christensen, C.M., and Nelson, G.H. (1967). Estrogenic metabolite produced by Fusarium graminearum in stored corn. Appl. Microbiol., 15, 497–503.Google Scholar
  32. Mirocha, C.J., Christensen, C.M., and Nelson, G.H. (1968). Physiologic activity of some fungal estrogens produced by Fusarium. Cancer Res., 28, 2319–2322.Google Scholar
  33. Mirocha, C.J., Schauerhamer, B., Christensen, C.M., Niku-Paavola, M.L., and Nummi, M. (1979). Incidence of zearalenol (Fusarium mycotoxin) in animal feed. Appl. Environ. Microbiol., 38, 749–750.Google Scholar
  34. Moneque, R.J., Combs, G.E., Edds, G.T., and Wallace H.D. (1977). The effects of various levels of aflatoxins on young swine, In: Fl. Agr. Exp. Stat. Res. Rpt. AL-1977-5, pp. 1-6, Gainesville, Florida.Google Scholar
  35. NRC. (1988). Nutrient Requirements of Domestic Animals. No. 2 Nutrient Requirements of Swine. Ninth Revised Ed. National Academy of Sciences-National Research Council, Washington, D.C.Google Scholar
  36. Olsen, M., Patterson, H., and Kiessling, K.H. (1981). Reduction of zearalenone to zearalenol in female rat liver by alpha-hydroxy-steroiddehydrogenase. Acta. Pharmacol. Toxicol., 48, 157–161.CrossRefGoogle Scholar
  37. SAS. (1982). SAS User’s Guide. Statistics. Statistical Analysis System Institute, Inc., Cary, NC.Google Scholar
  38. Sisk, D.B. and Carlton, W.W. (1972). Effect of dietary protein concentration on response of miniature swine to aflatoxins. Amer. J. Vet. Res., 33, 107–114.Google Scholar
  39. Smith, T.K. (1980). Influence of dietary fiber, protein, and zeolite on zearalenone toxicosis in rats and swine. J. Anim. Sci., 50, 278–285.Google Scholar
  40. Smith, J.W., Hill, C.H., and Hamilton, P.B. (1971). The effect of dietary modifications on aflatoxicosis in the broiler chicken. Poul. Sci., 50, 768–774.CrossRefGoogle Scholar
  41. Southern, L.L. and Clawson, A.J. (1979). Effects of aflatoxins on finishing swine. J. Anim. Sci., 49, 1006–1011.Google Scholar
  42. Steel, R.G.D. and Torrie, J.H. (1980). Principles and Procedures of Statistics. Chapt. 9, pp. 195–233, McGraw-Hill Book Co., New York.Google Scholar
  43. Tuite, J. (1979). Field and storage conditions for the production of mycotoxins and geographic distribution of some mycotoxin problems in the United States, In: Interactions of Mycotoxins in Animal Production, pp. 19–42, National Academy of Sciences, Washington, D.C.Google Scholar
  44. Tung, H.-T., Donaldson, W.E., and Hamilton, P.B. (1972). Altered lipid transport during aflatoxicosis. Tox. Appl. Pharm., 22, 97–104.CrossRefGoogle Scholar
  45. Tyczkowska, K., Hutchins, J.E., and Hagler, W.M., Jr. (1987). Liquid Chromatographic determination of aflatoxicol in porcine liver. J. Assoc. Offic. Anal. Chem., 70, 475–478.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. T. Coffey
    • 1
  • W. M. HaglerJr.
    • 2
  • E. E. Jones
    • 3
  • J. M. Cullen
    • 4
  1. 1.Department of Animal ScienceNorth Carolina State UniversityRaleighUSA
  2. 2.Mycotoxin Laboratory, Department of Poultry ScienceNorth Carolina State UniversityRaleighUSA
  3. 3.Departments of Animal Science and BiochemistryNorth Carolina State UniversityRaleighUSA
  4. 4.College of Veterinary MedicineNorth Carolina State UniversityRaleighUSA

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