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Immunotoxicity of Trichothecene Mycotoxins

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Book cover Biodeterioration Research

Part of the book series: Biodeterioration Research ((BIOR,volume 3))

Abstract

The trichothecene mycotoxins are sesquiterpene alcohols or esters. Several genera of imperfect fungi, including; Trichoderma, Trichothecium, Myrothecium, Stachybotrys, Cephalosporium, and Verticimonosporium are known to produce trichothecene mycotoxins, most notable, however, are several Fusarium species. To date approximately 100 naturally occurring trichothecene mycotoxins have been identified. However, the rarity of most has limited toxicology research, primarily, to the study of; 4-deoxynivalenol (DON, vomitoxin), 3-acetyl-deoxynivalenol (3-acetyl-DON), diacetoxyscirpenol (DAS, anguidine), fusarenon-X (FUS-X), nivalenol (NIV) , and T-2 toxin (T-2). Often described as secondary, plant metabolites, without obvious benefit to the organism, mycotoxins are believed to be produced in response to various environmental stresses. Trichothecene-producing fungi are distributed widely, and found in temperate as well as subtropical climates.

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References

  • Anaissie, E., Kantarjian, H., Jones, P., Barlogie, B., Luna, M., Lopez Berestein, G., and Bodey, G.P. (1986). Fusarium: A newly recognized fungal pathogen in immunosuppressed patients. Cancer, 57, 2141–2145.

    Article  CAS  Google Scholar 

  • Anderson, D.W., Black, R.M., Lee, C.G., Pottage, C, Rickard, R.L., Sandford, M.S., Webber, T.D., and Williams, N.E. (1989). Structure-activity studies of trichothecenes: cytotoxicity of analogues and reaction products derived from T-2 toxin and neosolaniol. J. Med. Chem., 32, 555–562.

    Article  CAS  Google Scholar 

  • Atkinson, H.A.C. and Miller, K. (1984). Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol, and zearalenone on induction of rat and human lymphocyte proliferation. Tox. Lett., 23, 215–221.

    Article  CAS  Google Scholar 

  • Beasley, V.R. (1989). Trichothecene Mycotoxicosis: Pathophysiologic Effects, I & II, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Bhat, R.V., Beedu, S.R., Ramakrishna, Y., and Munshi, K.L. Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir Valley, India. Lancet, January 7, 35-37.

    Google Scholar 

  • Burgess, A. and Nicola, N. (1983). Growth Factors and Stem Cells, Academic Press, New York, NY.

    Google Scholar 

  • Carroll, B.J., Person, M.J., and Martin, F.I.R. (1969). Evaluation of three acute tests of hypothalamic-pituitary-adrenal function. Metabolism, 18, 476–483.

    Article  CAS  Google Scholar 

  • Claman, H.N. (1972). Corticosteroids and lymphoid cells. New Engl. J. Msol., 287, 388–397.

    Article  CAS  Google Scholar 

  • Cooray, R. (1984). Effects of some mycotoxins on mitogen-induced blastogenesis and SCE frequency in human lymphocytes. Fd. Chem. Toxicol., 22, 529–534.

    Article  CAS  Google Scholar 

  • Cooray, R. and Lindahl-Kiessling, K. (1987). Effect of T-2 toxin on the spontaneous antibody-secreting cells and other non-lymphoid cells in the murine spleens. Fd. Chem. Toxicol., 25, 25–29.

    Article  CAS  Google Scholar 

  • Corrier, D.E., Holt, P.S., and Mollenhauer, H.H. (1987). Regulation of murine macrophage phagocytosis of sheep erythrocytes by T-2 toxin. Am. J. Vet. Res., 48, 1304–1307.

    CAS  Google Scholar 

  • Corrier, D.E., Zip-rin, R.L., and Mollenhauer, H.H. (1987). Modulation of cell-mediated resistance to listeriosis in mice given T-2 toxin. Toxicol. Appl. Pharmacol., 89, 323–331.

    Article  CAS  Google Scholar 

  • Desiderio, J.V., Kiener, P.A., Lin, P.F., and Warr, G.A. (1989). Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor-alpha. Infect. Immun., 57, 1615–1617.

    CAS  Google Scholar 

  • Doyle, T.W. and Bradner, W.T. (1980). Trichothecanes, In: Anticancer Agents Based on Natural Product Models, pp.43–72 (J.M. Cassady and J.D. Douros, eds.), Academic Press, New York, NY.

    Google Scholar 

  • Efrat, S., Zelig, S., Yagen, B., and Kaempfer, R. (1984). Superinduction of human Interleukin-2 messenge RNA by inhibitors of translation. Biochem. Biophys. Res. Comm., 123, 842–848.

    Article  CAS  Google Scholar 

  • Forsell, J.H., Kateley, J.R., Yoshizawa, T., and Pestka, J.J. (1985). Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites. Appl. Environ. Microbiol., 49, 1523–1526.

    CAS  Google Scholar 

  • Friend, S.C.E., Babuik, L.A., and Schieffer, H.B. (1983). The effects of dietary T-2 toxin on the immunological function and Herpes Simplex reactivation in Swiss mice. Toxicol. Appl. Pharmacol., 69, 234–244.

    Article  CAS  Google Scholar 

  • Fromentin, H., Salazar-Mejicanos, S., and Mariat, F. (1980). Pouvoir pathogene de Candida albicans pour la souris normale ou deprimee par une mycotoxine: le diacetoxyscirpenol. Ann. Microbiol., 131 b, 39–46.

    Google Scholar 

  • Gerberick, G.F., Sorenson, W.G., and Lewis, D.M. (1984). The effects of T-2 toxin on alveolar macrophages function in vitro. Environ. Res., 33, 246–260.

    Article  CAS  Google Scholar 

  • Gerberick, G.F. and Sorenson, W.G. (1983). Toxicity of T-2 toxin, a Fusarium mycotoxin, to alveolar macrophages in vitro. Environ. Res., 32, 269–285.

    Article  CAS  Google Scholar 

  • Goodwin, J.W., Bottomley, R.H., Vaughn, C.B., Frank, J., and Pugh, R.P. (1983). Phase 2 evaluation of anguidine in central nervous system tumors: a southwest oncology group study. Canc. Treat. Rep., 67, 285–286.

    CAS  Google Scholar 

  • Jacobs, D.M. (1981). Immunomodulatory effects of bacterial lipopolysaccharides. J. Immunopharmacol., 3, 119–132.

    Article  CAS  Google Scholar 

  • Jelinek, C.F., Pohland, A.E., and Wood, G.E. (1989). Worldwide occurrence of mycotoxins in foods and feeds-an update. J. Assoc. Off. Anal. Chem., 72, 223–230.

    CAS  Google Scholar 

  • Kanai, K. and Kondo, E. (1984). Decreased resistance to mycobacterial infection in mice fed a trichothecene compound (T-2 toxin). Japan. J. Med. Sci. Biol., 37, 97–104.

    CAS  Google Scholar 

  • Kaneko, T., Schmitz, H., Essery, J.M., Rose, W., Howell, H.G., O’Herron, F.A., Nachfolger, S., Huftalen, J., Bradner, W.T., Partyka, R.A., Doyle, TW., Davies, J., and Cundliffe, E. (1982). Structural Modifications of anguidine and anti-tumor activities of its analogues. J. Med. Chem., 25, 579–589.

    Article  CAS  Google Scholar 

  • Liao, L.L., Grollman, A.P., and Horwitz, S.B. (1976). Mechanisms of action of the 12, 13 epoxy trichothecene anguidine, an inhibitor of protein synthesis. Biochim. Biophys. Acta., 454, 273–284.

    Article  CAS  Google Scholar 

  • Loenzana, R.M., Beasley, V.R., Buck, W.B., Ghent, A.W., Lundeen, G.R., and Poppenga, R.H. (1985). Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF, thromboxane B2 and acid-base parameters. Fund. Appl. Toxicol., 5, 879–892.

    Article  Google Scholar 

  • Masuda, E., Takemoto, T., Tatsuno, T., and Obara, T. (1982). Immunosuppressive effect of a trichothecene mycotoxin, fusarenon-X in mice. Immunology, 45, 743–749.

    CAS  Google Scholar 

  • Mayer, C.F. (1953). Endemic panmyelotoxicosis in the Russian grain belt. Part I: The clinical aspects of alimentary toxic aleukia (ATA) a comprehensive review. Milit. Surg., 113, 173–189.

    CAS  Google Scholar 

  • McLaughlin, C.S., Vaughan, M.H., Campbell, I.M., Wei, C.M., Stafford, M.E., and Hansen, B.S. (1977). Inhibition of protein synthesis by trichothecenes, In: Mycotoxins in Human and Animal Health, pp. 263–273 (J.V. Rodricks, C.W. Hesseltine, and M.A. Mehlman, eds.), Pathtox Publishers, Inc., Park Forest South, IL.

    Google Scholar 

  • Melmed, R.N., Ishai-Micheali, R., and Yagen, B. (1985). Differential inhibition by T-2 toxin of total protein, DNA and isoprenoid synthesis in the culture macrophage cell line J774. Biochem. Pharmacol., 34, 2809–2812.

    Article  CAS  Google Scholar 

  • Miller, K., and Atkinson, H.S.C. (1986). The in vitro effects of trichothecenes on the immune system. Fd. Chem. Toxicol., 24, 545–549.

    Article  CAS  Google Scholar 

  • Nakane, A., Minagawa, T., and Kato, K. (1988). Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection. Infect. Immun., 56, 2563–2569.

    CAS  Google Scholar 

  • Niyo, K. A., Richard, J. L., Niyo, Y., and Tiffany, L. H. (1988). Effects of T-2 mycotoxin ingestion on phagocytosis of Aspergillus fumigatus conidia by rabbit alveolar macrophages and on hematologic, serum biochemical, and pathological changes in rabbits. Am. J. Vet. Res., 49, 1766–1773.

    CAS  Google Scholar 

  • Otokawa, M. (1983). Immunological disorders, In: Trichothecenes, Chemical, Biological, and Toxicological Aspects, Developments in Food Science 4, pp. 163–176 (Y. Ueno, ed.), Elsevier, New York, NY.

    Google Scholar 

  • Rafai, P. and Tuboly, S. (1982). Effect of T-2 toxin on adrenocortical function and immmune response in growing pigs. Zbl. Vet. Med., 29, 558–565.

    Article  CAS  Google Scholar 

  • Robbana-Barnat, S., Lafarge-Frayssinet, C., Cohen, H., Neish, G.A., and Frayssinet, C. (1988). Immunosuppressive properties of deoxynivalenol. Toxicology, 48, 155–166.

    Article  CAS  Google Scholar 

  • Rodricks, J.V., Hesseltine, C.W., and Mehlman, M.A. (1977). Mycotoxins in Human and Animal Health, Pathtox Publishers, Inc., Park Forest South, IL.

    Google Scholar 

  • Rosenstein, Y., Kretschmer, R.R., and Lafarge-Frayssinet, C. (1981). Effect of Fusarium toxins, T-2 toxin and diacetoxyscripenol on murine T-dependent immune responses. Immunology, 44, 555–560.

    CAS  Google Scholar 

  • Rosenstein, Y., Lafarge-Frayssinet, C., Lespinats, G., Loisillier, F., Lafont, P., and Frayssinet, C. (1979). Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol. Immunology, 36, 111–117.

    CAS  Google Scholar 

  • Rosenstein, Y. and Lafarge-Frayssinet, C. (1983). Inhibitory effect of Fusarium T-2 toxin on lymphoid DNA and protein synthesis. Toxicol. Appl. Pharmacol., 70, 283–288.

    Article  CAS  Google Scholar 

  • Ryu, J., Ohtsubo, K., Izumiyama, N., Nakamura, K., Tanaka, T., Yamamura, H., and Ueno, Y. (1988). The acute and chronic toxicities of nivalenol in mice. Fund. Appl. Toxicol., 11, 38–47.

    Article  CAS  Google Scholar 

  • Schiefer, H.B., Rousseaux, C.G., Hancock, D.S., and Blakely, B.R. (1987). Effects of low-level long-term oral exposure to T-2 toxin in CD-1 mice. Fd. Chem. Toxicol., 25, 593–601.

    Article  CAS  Google Scholar 

  • Strum, A.W., Grave, W., and Kwee, W.S. (1989). Disseminated Fusarium oxysporum infection patient with heatstroke. Lancet, April 29, 968.

    Article  Google Scholar 

  • Tai, J.H., and Pestka, J.J. (1988a). Impaired murine resistance to Salmonella typhimurium following oral exposure to the trichothecene T-2 toxin. Fd. Chem. Toxicol., 26, 691–698.

    Article  CAS  Google Scholar 

  • Tai, J.H., and Pestka, J.J. (1988b). Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice. Tox. Lett., 44, 191–200.

    Article  CAS  Google Scholar 

  • Taylor, M.J., Pang, V.F., and Beasley, V.R. (1989a). The immunotoxicity of trichothecene mycotoxins, In: Trichothecene Mycotoxicosis: Pathophysiologic Effects, II, pp. 1–37 (V. Beasley, ed.), CRC Press, Boca Raton, FL.

    Google Scholar 

  • Taylor, M.J., Smart, R.A., and Sharma, R.P. (1989b). Relationship of the hypothalamic-pituitary-adrenal axis with chemically induced immunomodulation. I. Stress-like response after exposure to T-2 toxin. Toxicology, 56, 179–195.

    Article  CAS  Google Scholar 

  • Taylor, M.J., Warren, R. P., and Sharma, R.P. (1989c). Relationship of the hypothalamic-pituitary-adrenal axis with chemically induced immunomodulation. II. Effects of T-2 toxin on T-independent and T-dependent antibody responses. In manuscript.

    Google Scholar 

  • Tomar, R.S., Blakely, B.R., and Decoteau, W.E. (1988). Antibody-producing ability of mouse spleen cells after subacute dietary exposure to T-2 toxin. Int. J. Immunopharmacol., 10, 145–151.

    Article  CAS  Google Scholar 

  • Tomar, R.S., Blakely, B.R., and Decoteau, W.E. (1987). Immunological responsiveness of mouse spleen cells after in vivo or in vitro exposure to 3-acetydeoxynivalenol. Fd. Chem. Toxicol., 25, 393–398.

    Article  CAS  Google Scholar 

  • Tomar, R.S., Blakely, B.R., Schieffer, H.B., and Decoteau, W.E. (1986). In vitro effects of 3-acetyldeoxynivalenol on the immune response of human peripheral blood lymphocytes. Int. J. Immunopharmacol., 8, 125–130.

    Article  CAS  Google Scholar 

  • Tremel, H., Strugala, G., Forth, W., and Fichtl, B. (1985). Dexamethasone decreases lethality of rats in acute poisoning with T-2 toxin. Arch. Toxicol.

    Google Scholar 

  • Ueno, Y. (1983). Trichothecenes: Chemical, Biological and Toxicological Aspects, Developments in Food Science 4, Elsevier, New York, NY.

    Google Scholar 

  • Ueno, Y., Nakajima, M., Sakai, K., Ishii, K., Sato, N., and Shimada, N. (1973). Comparative toxicology of trichothecene mycotoxins: Inhibition of protein synthesis in animal cells. J. Biochem., 74, 285–296.

    CAS  Google Scholar 

  • Vidal, D. and Mavet, S. (1989). In vitro and in vivo toxicity of T-2 toxin, a Fusarium mycotoxin, to mouse peritoneal macrophages. Infect. Immun., 57, 2260–2264.

    CAS  Google Scholar 

  • Wyllie, T.D. and Morehouse, L.G. (1978). Mycotoxic Fungi, Mycotoxins, Mycotoxicoses: An Encyclopedic Handbook. Mycotoxicoses of Domestic and Laboratory Animals, Poultry, and Aquatic Invertebrates and Vertebrates, 2, Marcel Dekker, Inc., New York, NY.

    Google Scholar 

  • Yap, H., Murphy, W., DiStefano, A., Blumenschein, G., and Bodey, G. (1979). Phase II study of anguidine in advanced breast cancer. Canc. Treat. Rep., 63, 789–791.

    CAS  Google Scholar 

  • Yarom, R., Sherman, Y., More, R., Ginsburg, I., Borinski, R., and Yagen, B. (1984). T-2 toxin effect on bacterial infection and leukocyte functions. Toxicol. Appl. Pharmacol., 75, 60–68.

    Article  CAS  Google Scholar 

  • Ziprin, R.L. and Corrier, D.E. (1987). Listeriosis in diacetoxyscirpenol-treated mice. Am. J. Vet. Res., 48, 1516–1519.

    CAS  Google Scholar 

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  1. National Institutes of Health, National Institute of Environmental Health Science, DTRT, STB, Research Triangle Park, NC, 27709, USA

    Michael J. Taylor

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  1. Bureau of Toxic Substances, Virginia Department of Health, 109 Governor St., Room 918, Richmond, Virginia, 23219, USA

    Gerald C. Llewellyn (Director) (Director)

  2. Department of Forensic Sciences, The George Washington University, Washington, D.C., 20052, USA

    Charles E. O’Rear (Professor & Chairman) (Professor & Chairman)

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Taylor, M.J. (1990). Immunotoxicity of Trichothecene Mycotoxins. In: Llewellyn, G.C., O’Rear, C.E. (eds) Biodeterioration Research. Biodeterioration Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9453-3_6

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  • DOI: https://doi.org/10.1007/978-1-4757-9453-3_6

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