Abstract
Serotonin (5-hydroxytryptamine, 5-HT) functions as a neurotransmitter affecting a variety of tissues, including gastrointestinal smooth muscle and striated limb muscle (Bulbring and Gershon, 1967; Ooms et al., 1986). It has also been shown to be a potent vasoconstricting agent (Carter, 1961). As a vasoconstrictor, serotonin causes decreased blood flow through capillaries to skeletal muscles. The decreased oxygen and nutrient exchange between blood and the “isolated” skeletal musculature results in changes in both histological appearance and muscle function (Erspamer, 1961). However, evidence suggesting that serotonin acts more directly on muscle cells has been reported. Attention has been given to studies testing the involvement of receptors responding to 5-HT stimulation in both vascular smooth muscle and skeletal muscle in an effort to discern the receptor subtype which may be in part responsible for the serotonin induced muscle myopathy. Interest has developed in attempting to determine which antagonists for distinct serotonin receptors will be effective therapeutically when administered to animal subjects suffering from serotonin induced myopathies.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Branchek, T.A., Mawe, G.M., and Gershon, M.D. (1988). Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype (5-HT, ) with a selective agonist, H-hydroxyindalpine. J. Neurosci. 8, 7, 2582–2595.
Bulbring, E. and Gershon, M.D. (1967). 5-HT participation in the vagai inhibitory innervation of the stomach. J. Physiol. 192, 823–846.
Campbell, G.B., Scherz, M.W., Keana, J.F.W. and Weber, E. (1989). Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin. J. Neurosci. 9(10), 3380–3391.
Cater, D.B., Garattini, S. and Silver, L.A. (1961). Changes of oxygen tension in brain and somatic tissues induced by vasodilator and vasoconstrictor drugs. Proc. Royal Soc. Lond. 33, 345–353.
Clarke, D.E., Craig, D.A. and Fozard, J.R. (1989). The 5-HT4 receptor: naughty, but nice. TIPS, 10, 385–386.
Erspamer, V. (1966). Handbook of experimental pharmacology, Vol 10. 5-hydroxytryptamine and related indole alkylamines. Springer, Berlin.
Kaumann, A.J. (in press) (1990). 5-HT receptors mediate positive inotropism in the human atrial appendage. Br. J. Pharmacol.
Kimbrough, T.D. and Llewellyn, G.C. (1988). A gastrointestinal function bioassay evaluation of the mycotoxin, T-2 Trichothecene. Intl. Biodet. 24, 427–434.
Ooms, L.A.A., Degryse, A-D.A.Y., Fransen, J.L.A., and Van Mol, K.A.C. (1986). Treatment of chronic myopathies in horses with the serotonin S2-antagonist R 50970: a preclinical study. Drug Dev. Res. 8 (1–4), 219–223.
Verheyen, A., Vlaminckx, E., Remeysen, P. and Borgers, M. (1981). The influence of ketanserin, a new S2 receptor antagonist on experimentally induced skeletal muscle myopathy in the rat. Virchows Arch. (A), 393:265–272.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mooney, R.L., Llewellyn, G.C., Kimbrough, T.D. (1990). Serotonin Toxicity Causes Myodeterioration of Skeletal Muscle Function in Albino Mice. In: Llewellyn, G.C., O’Rear, C.E. (eds) Biodeterioration Research. Biodeterioration Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9453-3_52
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9453-3_52
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9455-7
Online ISBN: 978-1-4757-9453-3
eBook Packages: Springer Book Archive