Abstract
Zearalenone is an estrogen produced by several species of Fusarium on corn and other cereal grains (Caldwell and Tuite, 1974; Gross and Robb, 1975; Bottalico, 1979). Its presence in animal feeds and subsequent consumption have been associated with hyperestrogenism and other reproductive disorders in swine (Miller et al., 1973), poultry (Meronuck et al., 1970; Allen et al., 1981a,b) and cattle (Mirocha et al., 1968). Zearalenol, which is produced in its two epimeric forms as a metabolic precursor of zearalenone by certain species of Fusarium exhibits estrogenic activity (Peters, 1972; Mirocha et al., 1978; Bottalico et al., 1985; Richardson et al., 1985). α-Zearalenol has three to four times as much estrogenic activity as zearalenone while β-zearalenol has about the same or slightly less estrogenicity as zearalenone (Peters, 1972; Mirocha et al., 1978; Hagler et al., 1979). Zearalenone and zearalenol also have some anabolic activity that is useful in animal nutrition (Hidy et al., 1977).
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References
Allen, N.K., Mirocha, C.J., Aakhus-Allen, S., Bitgood, J.J., Weaver, G., and Bates, F. (1981). Effect of dietary zearalenone on reproduction in chickens. Poultry Sci. 60, 1165–1174.
Allen, N.K., Mirocha, C.J., Weaver, G., Aakhus-Allen, S., and Bates, F. (1981). Effects of dietary zearalenone on finishing broiler chickens and young turkey poults. Poultry Sci. 60, 124–131.
Bacon, C.W., Robbins, J.D., and Barter, J.K. (1977). Media for identification of Gibberella zeae and production of F-2 (zearalenone). Appl. Environ. Microbiol. 33, 445–449.
Bottalalico, A. (1979). On the occurrence of zearalenone in Italy. Mycopathologia 67, 119–121.
Bottalico, A., Visconti, A., Logrieco, A., Solfrizzo, M., and Mirocha, C.J. (1985). Occurrence of zearalenols (diastereomeric mixture) in corn stalk rot and their production by associated Fusarium species. Appl. Environ. Microbiol. 49, 547–551.
Caldwell, R.W. and Tuite, J. (1974). Zearalenone in freshly harvested corn. Phvtopathology 64, 752–753.
Eugenio, C.P., Christensen, C.M., and Mirocha, C.J. (1970). Factors affecting production of the mycotoxin F-2 by Fusarium roseum. Phytopathologv 60, 1055–1057.
Gross, V.J. and Robb, J. (1975). Zearalenone production in barley. Ann. Appl. Biol., 80, 211–216.
Hagler, W.M., Jr., Mirocha, C.J., Pathre, S.V., and Behrens, J.C. (1979). Identification of the naturally occurring isomer of zearalenol produced by Fusarium roseum ‘Gibbosum’ in rice culture. Appl. Environ. Microbiol. 37, 848–853.
Hagler, W.M., Jr. and Mirocha, C.J. (1980). Biosynthesis of [14C] zearalenone from [1-14C]-acetate by Fusarium roseum ‘Gibbosum’. Appl. Environ. Microbiol. 39, 668–670.
Hidy, P.H., Baldwin, R.S., Gresham, R.L., Keith, C.L., and McMullen, J.R. (1977). Zearalenone and some derivatives: production and biological activities. Adv. Appl. Microbiol. 22, 59–82.
Marasas, W.F.O., Nelson, P.E., and Toussoun, T.A. (1984). Toxigenic FUSARIUM Species: Identity and Mycotoxicology. pp. 99–110, The Pennsylvania State University Press, College Park, PA.
Meronuck, R.A., Garren, K.H., Christensen, C.M., Nelson, G.H., and Bates, F. (1970). Effects on turkey poults and chicks of rations containing corn invaded by Penicillium and Fusarium species. Am. J. Vet. Res. 31, 551555.
Miller, J.K., Hacking, A., and Gross, V.J. (1973). Stillbirths, neonatal mortality and small litters in pigs associated with the ingestion of Fusarium toxins by pregnant sows. Vet. Rec. 93, 555–559.
Mirocha, C.J., Harrison, J., Nichols, A.A., and McClintock, M. (1968). Detection of a fungal estrogen (F-2) in hay associated with infertility in dairy cattle. Appl. Microbiol. 16, 797–798.
Mirocha, C.J., Pathre, S.V., Behrens, J., and Schauerhamer, B. (1978). Uterotropic activity of cis and trans isomers of zearalenone and zearalenol. Aool. Environ. Microbiol. 35, 986–987.
Peters, C.A. (1972). Photochemistry of zearalenone and its derivatives. J. Med. Chem. 15, 867–868.
Richardson, K.E., Hagler, Jr., W.M., and Hamilton, P.B. (1984). Bioconversion of a-[14C] zearalenol and ß-[14C] zearalenol into [14C] zearalenone by Fusarium roseum ‘Gibbosum’. Apol. Environ. Microbiol. 47, 1206–1209.
Richardson, K.E., Hagler, Jr., W.M., and Mirocha, C.J. (1985). Production of zearalenone, a-and ß-zearalenol by Fusarium spp. in rice culture. J. Agric. Food Chem. 33, 862–866.
Sarudi, I. (1976). Hydrogenation used in the detection of zearalenone (F-2 toxin). Acta Aliment. 5, 37–40.
SAS. (1982). SAS Users Guide. Statistics. Statistical Analysis System Institute, Inc., Cary, NC. Shipchandler, M.T. (1975). Chemistry of zearalenone and some of its derivatives. Heterocycles 3, 471–520.
Steele, J.A., Mirocha, C.J., and Pathre, S.V. (1976). Metabolism of zearalenone by Fusarium roseum ‘Graminearum’. Mycopathologia 57, 77–78.
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Richardson, K.E., Hagler, W.M., Hamilton, P.B. (1994). Stimulation of Zearalenone Production in Rice Cultures of Fusarium Semitectum by Addition of Zearalenone and α-and β-Zearalenol. In: Llewellyn, G.C., Dashek, W.V., O’Rear, C.E. (eds) Mycotoxins, Wood Decay, Plant Stress, Biocorrosion, and General Biodeterioration. Biodeterioration Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9450-2_18
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DOI: https://doi.org/10.1007/978-1-4757-9450-2_18
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