Ultrastructural Analysis of Whether Dietary Manganese Protects Against Aflatoxin-Induced Liver Damage in Rats

  • Gerald C. Llewellyn
  • Betty A. Floyd
  • Robert L. Knight
  • William V. Dashek
Part of the Biodeterioration Research book series (BIOR, volume 4)


Aflatoxins (AFTs) are secretions of both Aspergillus parasiticus and A. flavus (Nesbit et al., 1962), two fungi, which can grow upon economically-important crop plants (Wogan, 1964). These secretions are bifuranocoumarins belonging to the family of compounds know as mycotoxins. Of interest from this group are the aflatoxins (AFTs), especially aflatoxin B1 (AFB1). The AFTs are heptocarcinogenic, mutagenic, and teratogenic. Perhaps, the most widely studied aspect of the AFTs is their carcinogenic property but only a few investigators have concerned themselves with preventing AFT-induced heptocarcinogenesis. For example, Novi (1981) reported that glutathione can alter the development of AFB1-induced hepatocellular carcinomas. One under-explored prevention possibility involves the employment of trace elements, e.o., copper, manganese, and zinc as potential protectors against aflatoxicosis. Several studies regarding this topic have emanated from a single laboratory (Kimbrough et al., 1981; Lalor and Llewellyn, 1981; Llewellyn et al., 1980; 1981; 1983; 1985; Weekley et al., 1981). Both comprehensive (Llewellyn et al., 1982) and critical (Llewellyn et al., 1984) reviews evaluating studies regarding trace element-induced protection against aflatoxicosis have appeared.


Mongolian Gerbil Aspergillus Parasiticus Dietary Copper Electron Dense Particle Lead Hydroxide 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Gerald C. Llewellyn
    • 1
    • 2
  • Betty A. Floyd
    • 3
  • Robert L. Knight
    • 4
  • William V. Dashek
    • 5
  1. 1.Department of Forensic ScienceThe George Washington UniversityUSA
  2. 2.The Delaware Department of Natural Resources and Environmental ControlNew CastleUSA
  3. 3.Department of BiologyVirginia Commonwealth UniversityRichmondUSA
  4. 4.Electron Microscopy SectionCharleston Area Medical CenterCharlestonUSA
  5. 5.Department of BiologyClark Atlanta UniversityAtlantaUSA

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