Skip to main content
SpringerLink
Log in
Book cover

Biochemistry of Zinc pp 165–192Cite as

Zinc and Immunity

  • Chapter

Part of the book series: Biochemistry of the Elements ((BOTE,volume 11))

Abstract

During the past decade considerable knowledge has accumulated concerning the role of zinc in cellular immunity. It has been known for many years that zinc deficiency in experimental animals results in atrophy of thymic and lymphoid tissue (Prasad and Oberleas, 1971). These changes are associated with a variety of functional abnormalities.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen, J. I., Perri, R. T., McClain, C. J., and Kay, N. E., 1983. Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency, J. Lab. Clin. Med. 102: 577.

    CAS  Google Scholar 

  • Antoniou, L. D., Shahloub, R. J., and Schecter, G. P., 1981. The effect of zinc on cellular immunity in chronic uremia, Am. J. Clin. Nutr. 32: 1912.

    Google Scholar 

  • Bach, J. F., 1983. Thymulin (FTS-Zn), Clin. Immunol. Allergy 3: 133.

    CAS  Google Scholar 

  • Bach, J. F., Dardenne, M., Pleau, J. M., and Rosa, J., 1977. Biochemical characterization of a serum thymic hormone, Nature 266: 55.

    Article  CAS  Google Scholar 

  • Baer, M. T., King, J. C., Tamura, T., Mangen, S., Bradfield, R. B., Weston, W. L., and Daugherty, N. A., 1985. Nitrogen utilization, enzyme activity, glucose intolerance, and leukocyte chemotaxis in human experimental zinc depletion, Am. J. Clin. Nutr. 41: 1220.

    CAS  Google Scholar 

  • Ballester, O. F., and Prasad, A. S., 1983. Anergy, zinc deficiency and decreased nucleoside phosphorylase activity in patients with sickle cell anemia, Ann. Intern. Med. 98: 180.

    CAS  Google Scholar 

  • Ballester, O. F., Abdallah, J. M., and Prasad, A S., 1986. Lymphocyte subpopulation abnormalities in sickle cell anemia, Am. J. Hematol. 21: 23.

    Article  CAS  Google Scholar 

  • Barrett-Conner, E., 1971. Bacterial infection and sickle cell anemia, Medicine 59: 97.

    Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1979. Altered thymic structure and mitogen responsiveness in postnatally zinc-deprived mice, Dev. Comp. Immunol. 3: 725.

    Article  CAS  Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., I 980a. Growth and development of postnatally zinc-deprived mice, J. Nutr. 110: 201.

    Google Scholar 

  • Beach, R. S., Gershwin, M. E., Makishima, R. K., and Hurley, L. S., 1980b. Impaired immunologic ontogeny in postnatal zinc deprivation, J. Nutr. 110: 805.

    CAS  Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1981. Nutritional factors and autoimmunity. I. Immunopathology of zinc deprivation in New Zealand mice, J. Immunol. 126: 1999.

    Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1982a. Gestational zinc deprivation in mice: Persistence of immunodeficiency for three generations, Science 218: 469.

    Article  CAS  Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., I982b. The reversibility of developmental retardation following murine fetal zinc deprivation, J. Nutr. 112: 1169.

    Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1982c. Nutritional factors and autoimmunity. II. Prolongation of survival in zinc-deprived NZB/W mice, J. Immunol. 128: 308.

    CAS  Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1982d. Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL/1 mice-the distinction between interacting dietary influences, J. Immunol. 129: 2686.

    CAS  Google Scholar 

  • Bensman, A., Dardenne, M., Morgant, G., Vesmant, D., and Bach, J. F., 1985. Decrease of biological activity of serum thymic factor in children with nephrotic syndrome, Int. J Pediatr. Nephrol. 5: 201.

    Google Scholar 

  • Blazsek, I., and Mathe, G., 1984. Zinc and immunity, Biomed. Pharmacother. 38: 187.

    CAS  Google Scholar 

  • Chandra, R. K., and Dayton, D. H., 1982. Trace element regulation of immunity and infection, Nutr. Res. 2: 721.

    Article  CAS  Google Scholar 

  • Cunnigham-Rundles, C., Cunningham-Rundles, S., Iwata, T., Incefy, G., Garofalo, J. A., Menendez-Botet, C., Lewis, V., Twomey, J. J., and Good, R. A., 1981. Zinc deficiency, depressed thymic hormones, and T lymphocyte dysfunction in patients with hypogammaglobulinemia, Clin. Immunol. Immunopathol. 21: 387.

    Article  Google Scholar 

  • Dardenne, M., Pleau, J. M., Nabarra, B., Lefrancier, P., Derrien, M., Choay, J., and Bach, J. F., 1982. Contribution of zinc and other metals to the biological activity of the serum thymic factor, Proc. Natl. Acad. Sci. USA 79: 5370.

    Article  CAS  Google Scholar 

  • Dardenne, M., Savino, W., Wade, S., Kaiserlian, D., Lemonneir, D., and Bach, J. F., 1984. In vivo and in vitro studies of thymulin in marginally zinc deficient mice, Eur. J. Immunol. 14: 454.

    Article  CAS  Google Scholar 

  • Douglas, R. G., Jr., Roberts, R. B., Romano, R., Metroka, C., Amberson, J., Soave, R., and Stover, D., 1984. Infectious complications in acquired immunodeficiency syndrome, in Acquired Immune Deficiency Syndrome ( M. S. Gottlieb, Jr., and E. Groopman, eds.), Liss, New York, p. 321.

    Google Scholar 

  • Duchateau, J., Delepesee, G., Virgens, R., and Collet, H. J., 1981. Beneficial effects of oral zinc supplementation on the immune response of old people, Am. J. Med. 70: 1001.

    Article  CAS  Google Scholar 

  • Fernandes, G., Nair, M., Onoe, K., Tanaka, T., Floyd, R., and Good, R. A., 1979. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice, Proc. Natl. Acad. Sci. USA 76: 457.

    Article  CAS  Google Scholar 

  • Fraker, P. J., 1983. Zinc deficiency: A common immunodeficiency state, Surv. Immunol. Res. 2: 155.

    CAS  Google Scholar 

  • Fraker, P. J., DePasquale-Jardieu, P., Zwickl, C. M., and Luecke, R. W., 1978. Regeneration of T-cell helper function in zinc deficient adult mice, Proc. Natl. Acad. Sci. USA 75: 5660.

    Article  CAS  Google Scholar 

  • Fraker, P. J., Haas, S., and Luecke, R. W., 1977. Effect of zinc deficiency on the immune response of the young adult A/J mouse, J. Nutr. 107: 1889.

    CAS  Google Scholar 

  • Fraker, P. J., Gershwin, M. E., Good, R. A., and Prasad, A S, 1985. Interrelationships between zinc and immune function, Fed. Proc. 45: 1474.

    Google Scholar 

  • Frost, P., Rabbani, P., Smith, J., and Prasad, A S, 1981. Cell mediated cytotoxicity and tumor growth in zinc deficient mice, Proc. Soc. Exp. Biol. Med. 167: 333.

    CAS  Google Scholar 

  • Gasintinel, L. N., Dardenne, M., Pleau, J. M., and Bach, J. F., 1984. Studies on the zinc binding to the serum thymic factor, Biochim. Biophys. Acta 797: 147.

    Article  Google Scholar 

  • Giblett, E. R., Ammann, A. J., Warn, D. W., Sandman, R., and Diamond, L. K., 1975. Nucleoside phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity, Lancet 1: 1010.

    Article  CAS  Google Scholar 

  • Golding, J. S., Maclver, J. E., and Went, L. H., 1959. The bone changes in sickle cell anemia and its genetic variants, J. Bone Jr. Surg. 41B: 711.

    Google Scholar 

  • Golub, M. S., Gershwin, M. E., Hurley, L. S., Baly, D. L., and Hendrickx, A. G., 1984. Studies of marginal zinc deprivation in rhesus monkeys. I. Influences on pregnant dams, Am. J. Clin. Nutr. 39: 265.

    CAS  Google Scholar 

  • Good, R. A., and Fernandes, G., 1979. Nutrition, immunity, and cancer-A review. I: Influence of protein or protein-calorie malnutrition and zinc deficiency on immunity, Clin. Bull. 9: 3.

    CAS  Google Scholar 

  • Good, R. A., Fernandes, G., Garofalo, A., Cunningham-Rundles, C., Iwata, T., and West, A., 1982. Zinc and immunity, Clinical, Biochemical, and Nutritional Aspects of Trace Elements (A. S. Prasad, ed.), Liss, New York, p. 189.

    Google Scholar 

  • Grummt, F., Waltl, G., Jantzen, H. M., Hamprecht, K., Huebscher, U., and Kuenzle, C. C., 1979. Diadenosine 5’,5“-D1,D4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha, Proc. Natl. Acad. Sci. USA 76: 6081.

    Article  CAS  Google Scholar 

  • Grummt, F., Weinman-Dorsch, C., Schneider-Schaulies, J., and Lux, A., 1986. Zinc as a second messenger of mitogenic induction, Exp. Cell Res. 163: 191.

    Article  CAS  Google Scholar 

  • Haddad, J. D., John, J. F., and Pappas, A. A., 1984. Cytomegalovirus pneumonia in sickle cell disease, Chest 86: 265.

    Article  CAS  Google Scholar 

  • Hardy, R. E., Cummings, C., Thomas, F., and Harrison, D., 1986. Cryptococcal pneumonia in a patient with sickle cell disease, Chest 89: 892.

    Article  CAS  Google Scholar 

  • Haynes, D. C., Gershwin, M. E., Golub, M. S., Cheung, A. T. W., Hurley, L. S., and Hendrickx, A. G., 1985. Studies of marginal zinc deprivation in rhesus monkeys. VI. Influence on the immunohematology of infants in the first year, Am. J. Clin. Nutr. 42: 252.

    CAS  Google Scholar 

  • Laussac, J. P., Haran, R., Dardenne, M., Lefrancier, P., and Bach, J. F., 1985. Nuclear magnetic resonance study of the interaction of zinc with thymulin, C.R. Acad. Sci. Ser. C 301: 471.

    CAS  Google Scholar 

  • Ma, D. D., Wylwestrowicz, T., Janossy, G., and Hoflbrand, A. V., 1983. The role of purine metabolic enzymes and terminal deoxynucleotidyl transferase in intrathymic T cell differentiation, Immunol. Today 4: 65.

    Article  CAS  Google Scholar 

  • Mann, J. R., Cotter, K. P., Walker, R. A., Bird, G. W. G., and Stuart, G., 1975. Anemia crisis in sickle cell disease, J. Clin. Pathol. 28: 341.

    Article  CAS  Google Scholar 

  • Meftah, S., and Prasad, A S., 1989. Nucleotides in lymphocytes of human subjects with zinc deficiency, J. Lab. Clin. Med. 114: 114.

    CAS  Google Scholar 

  • Meftah, S., Prasad, A. S., Lee, D.-Y., and Brewer, G. J., 1991. Ecto 5’-nucleotidase (5’NT) as a sensitive indicator of human zinc deficiency, J. Lab. Clin. Med. 118: 309.

    CAS  Google Scholar 

  • Mitchell, B. S., and Sidi, Y., 1985. Differential metabolism of guanine nucleosides by human lymphoid cell lines, Proc. Soc. Exp. Biol. Med. 179: 427.

    CAS  Google Scholar 

  • Nash, L., Iwata, T., Fernandes, G., Good, R. A., and Incefy, G., 1979. Effect of zinc deficiency on autologous rosette-forming cells, Cell. Immunol. 48: 238.

    Article  CAS  Google Scholar 

  • Oleske, J. M., Westphal, M. L., Shore, S., Gorden, D., Bogden, J. D., and Nahimias, A., 1979. Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica, Am. J. Dis. Child. 133: 915.

    CAS  Google Scholar 

  • Onwubalili, J. K., 1983. Sickle cell disease and infection, Journal of Infection 7 (1): 2.

    Article  CAS  Google Scholar 

  • Pilz, R. B., Willis, R. C., and Seegmiller, J. E., 1982. Regulation of human lymphoblast plasma membrane 5’nucleotidase, J. Biol. Chem. 257: 13544.

    CAS  Google Scholar 

  • Prasad, A S, and Oberleas, D., 1971. Changes in activities of zinc dependent enzymes in zinc deficient tissues of rats, J. Appl. Physiol. 31: 842.

    CAS  Google Scholar 

  • Prasad, A. S., and Rabbani, P., 1981. Nucleoside phosphorylase in zinc deficiency, Trans. Assoc. Am. Physicians 94: 314.

    CAS  Google Scholar 

  • Prasad, A. S., Kaplan, J., and Abdallah, J., 1986. Zinc deficiency as a basis for immunodeficiencies in sickle cell anemia (SCA), in Symposium: The Nature, Cellular and Biochemical Basis and Management of Immunodeftciencies ( R. A. Good and E. Lindenlaub, eds.), FKS Verlag, Stuttgart, p. 317.

    Google Scholar 

  • Prasad, A S, Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., and Dardenne, M., 1988. Serum thymulin in human zinc deficiency, J. Clin. Invest. 82: 1202.

    Article  CAS  Google Scholar 

  • Rabbani, P. I., Prasad, A S, Tsai, R., Harland, B. F., and Fox, M. R. S., 1987. Dietary model of production of experimental zinc deficiency in man, Am. J. Clin. Nutr. 45: 1514.

    CAS  Google Scholar 

  • Rappaport, E., Zamecnik, P. C., and Baril, E. F., 1981. HeLa cell DNA polymerase a is tightly associated with tryptophanyl-tRNA synthetase and diadenosine 5’,5“-Pl,P4-tetraphosphate binding activities, Proc. Natl. Acad. Sci. USA 78: 838.

    Article  Google Scholar 

  • Savino, W., Dardenne, M., Papiernik, M., and Bach, J. F., 1982. Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies, J. Exp. Med. 156: 628.

    Article  CAS  Google Scholar 

  • Sergeant, G. R., Topley, J. M., Mason, K., Sergeant, B. E., Pattison, S. E,. and Mohamed, R., 1981. Outbreak of aplastic crisis in sickle cell anemia associated with parvovirus like agent, Lancet 2: 595.

    Google Scholar 

  • Shulman, S. T., Bartlett, J., Clyde, W. A., and Ayoub, E. M., 1972. The unusual severity of mycoplasma pneumonia in children with sickle cell disease, N. Engl. J. Med. 287: 164.

    Article  CAS  Google Scholar 

  • Tapazoglou, E., Prasad, A. S., Hill, G., Brewer, G. J., and Kaplan, J., 1985. Decreased natural killer cell activity in zinc deficient subjects with sickle cell disease, J. Lab. Clin. Med. 105: 19.

    CAS  Google Scholar 

  • Zwickl, C. W., and Fraker, P. J., 1980. Restoration of the antibody mediated response of zinc/ caloric deficient neonatal mice, Immunol. Commun. 9: 611.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Hematology and Oncology, Wayne State University School of Medicine, USA

    Ananda S. Prasad

  2. Harper Hospital, Detroit, Michigan, USA

    Ananda S. Prasad

  3. Veterans Administration Medical Center, Allen Park, Michigan, USA

    Ananda S. Prasad

Authors
  1. Ananda S. Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Prasad, A.S. (1993). Zinc and Immunity. In: Biochemistry of Zinc. Biochemistry of the Elements, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9444-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9444-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9446-5

  • Online ISBN: 978-1-4757-9444-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation