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Biochemistry of Zinc pp 131–148Cite as

Zinc and Cells

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Part of the book series: Biochemistry of the Elements ((BOTE,volume 11))

Abstract

Many studies have shown that zinc ions as an integral part of tissues and biologic fluids play an important role in homeostatic mechanisms regulating the reactivity of tissues and cells. In lymphocytes, zinc acts as a nonspecific mitogen (Chvapil, 1976). Within a range of 1.5 to 4.5 × 10−4 M Zn concentration in the culture medium, the blastogenic transformation of lymphocytes as well as their mitosis was significantly increased after 6 days in comparison with the effect of phytohemagglutinin (PHA). Zinc acted as a weak mitogen (Kirchner and Ruhl, 1970; Ruhl et al., 1974). Surprisingly, only zinc and mercury were stimulatory. Calcium and magnesium did not affect DNA synthesis in the culture system. Mn2+, Co2+, Cd2+, Cu2+, and Ni2+ at concentrations from 10−3 to 10−7 M were inhibitory. Inasmuch as DNA-synthesizing enzymes are zinc dependent, one may assume that enhanced mitosis of lymphocytes by zinc may be the result of increased activity of enzymes involved in cell mitosis.

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology and Oncology, Wayne State University School of Medicine, USA

    Ananda S. Prasad

  2. Harper Hospital, Detroit, Michigan, USA

    Ananda S. Prasad

  3. Veterans Administration Medical Center, Allen Park, Michigan, USA

    Ananda S. Prasad

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© 1993 Springer Science+Business Media New York

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Prasad, A.S. (1993). Zinc and Cells. In: Biochemistry of Zinc. Biochemistry of the Elements, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9444-1_7

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  • DOI: https://doi.org/10.1007/978-1-4757-9444-1_7

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