Interactions of Zinc with Other Micronutrients

  • Ananda S. Prasad
Part of the Biochemistry of the Elements book series (BOTE, volume 11)


During the past two decades, it has become clear that the addition of a trace element to the animal diet alters the metabolism of other elements. In some instances the interaction between the added element and the responding element is complementary. For example, the dietary level of iron needed to maintain a given concentration of hemoglobin is dependent on the dietary copper level (Hill and Matrone, 1961). A majority of other interactions, however, are of antagonistic nature. For example, high levels of zinc added to diets are known to precipitate copper deficiency in animals and humans (Hill and Matrone, 1970; Prasad et al., 1978a). Several years ago, Hill and Matrone (1961) proposed that those elements whose electronic structure of the valence shell of the ions was the same, would act antagonistically to each other in biological systems (Hill, 1976).


Zinc Absorption Zinc Deficiency Plasma Zinc Level Hepatic Copper Copper Balance 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ananda S. Prasad
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, Division of Hematology and OncologyWayne State University School of MedicineUSA
  2. 2.Harper HospitalDetroitUSA
  3. 3.Veterans Administration Medical CenterAllen ParkUSA

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