In their famous, historic paper describing the double helix, Watson and Crick concluded: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a copying mechanism for the genetic material.” In a subsequent paper, the authors elaborated on this statement by proposing that the copying mechanism may involve each DNA strand serving as a template for synthesis of a complementary strand.
KeywordsDouble Helix Replication Fork Exonuclease Activity Thymine Dimer Okazaki Fragment
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