Biochemistry pp 273-291 | Cite as

The Citric Acid Cycle

  • J. Stenesh


The citric acid cycle, together with the electron transport system, constitutes stage III of catabolism (see Figure 8.2), also called cellular respiration. Because the citric acid cycle functions in both catabolism (Figure 11.1) and anabolism (Figure 11.2), we call it an amphibolic pathway. The citric acid cycle plays a pivotal role in cellular respiration, has multiple interconnections with other pathways, and provides for interconversions of numerous metabolites.


Lipoic Acid Flavin Adenine Dinucleotide Citric Acid Cycle Electron Transport System Pyruvate Dehydrogenase Complex 
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Selected Readings

  1. Barron, J. T., Kopp, S. J., Tow, J., and Parrillo J. E., Fatty acid, tricarboxylic acid cycle metabolites, and energy metabolism in vascular smooth muscle, Am. J. Physiol. 267: H764–H769 (1994).PubMedGoogle Scholar
  2. Beevers, H., The role of the glyoxylate cycle, in The Biochemistry of Plants, Vol. 4 (P. K. Stumpf and E. E. Conn, eds.), Academic Press, New York (1980).Google Scholar
  3. Beylot, M., Soloviev, M. V., David, E, Landau, B. R., and Brunengraber, H., Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo, J. Biol. Chem. 270: 1509–1514 (1995).PubMedCrossRefGoogle Scholar
  4. DiDonato, L., Des Rosiers, C., Montgomery, J. A., David, E, Garneau, M., and Brunengraber, H., Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the carbon-l3-labeling pattern of glutamate, J. Biol. Chem. 268: 4170–4180 (1993).Google Scholar
  5. Drozdov, L. N., et al.,The optimal structure of the tricarboxylic acid cy- cle multienzyme system of E. coli for the cases of cell growth on various carbon sources, Biokhimiya (Moscow) 59:368–380 (1994).Google Scholar
  6. Durschlag, H., et al.,Structural changes of citrate synthase upon ligand binding and upon denaturation, Prog. Colloid Polym. Sci. 93:222–230 (1993).Google Scholar
  7. Hiromasa, Y., Aso, Y., Yamashita, S., and Aikawa, Y., Homogeneity of the pyruvate dehydrogenase multienzyme complex from Bacillus stearothermophilus, J. Biochem (Tokyo) 117:467–470 (1995).Google Scholar
  8. Kleczkowski, L. A, Kinetics and regulation of the NAD(P)H-dependent glyoxylate-specific reductase from spinach leaves, Z. Naturforsch C 50:21–28 (1995).Google Scholar
  9. Kornberg, H. L., Tricarboxylic acid cycles, BioEssays 7: 236–238 (1987).CrossRefGoogle Scholar
  10. Krebs, H. A., The history of the tricarboxylic acid cycle, Perspect. Biol. Med. 14: 154–170 (1970).PubMedGoogle Scholar
  11. Mason, G. F., et al.,Simultaneous determination of the rates of the TCA cycle, glucose utilization, a-ketoglutarate/glutamate exchanges, and glutamine synthesis in human brain by NMR, J. Cereb. Blood Flow Metab. 15:12–25 (1995).Google Scholar
  12. Patel, M. S., and Roche, T. E., Molecular biology and biochemistry of pyruvate dehydrogenase complexes, FASEB J. 4: 3224–3233 (1990).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • J. Stenesh
    • 1
  1. 1.Western Michigan UniversityKalamazooUSA

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