We can consider biochemical systems to operate within four major frameworks. One of these is the origin of life—the chain of events leading to the first ancient cell from which all forms of life ultimately developed. A second framework deals with the properties of the modern cell, the basic unit of all living organisms and the site of most biochemical reactions. Water constitutes a third framework. This unusual solvent provides the internal aqueous environment of cells without which life, as we know it, would not be possible. Lastly, noncovalent interactions form an essential framework. Biochemical systems require these interactions for stabilization of proteins, nucleic acids, cell membranes, and the like. Noncovalent interactions also participate in the operation of many biochemical systems by affecting the interplay among low-molecular-weight compounds, macromolecules, and other structures.
KeywordsChemical Evolution Noncovalent Interaction Proton Acceptor Biochemical System Buffer Component
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