NMR as an Aid in Studying N-Alkylformamides and Metabolites
The common industrial and laboratory solvent DMF≠ and its close analogue NMF share the ability to cause hepatotoxicity in man. They differ, however, in their biological properties towards rodents. NMF is a hepatotoxin towards rats and mice and shows significant activity against tumours of murine  and human  origin grown in mice. DMF shows neither strong therapeutic nor hepatotoxic activity in mice, whereas NEF in mice shows hepatoxicity only [1, 3]. The explanation for these comparisons and contrasts may be connected with the nature and quantity of the metabolites formed from different N-alkylformamides in the various species. The characterization of the urinary metabolites by conventional techniques such as MS and UV spectrometry is hampered by their lability and lack of a suitable chromophore.
KeywordsUrinary Metabolite Free Induction Decay Mercapturic Acid Developmental Therapeutics Program Cancer Research Campaign
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