Abstract

Recent advances in instrumentalized TLC are described with emphasis on development techniques, radio-TLC and the spectroscopic characterization of substances in situ on the TLC plate. Brief descriptions of automated multiple development, overpressure TLC and centrifugal layer chromatography are given. The use of ‘linear analyzers’ for the detection of radioactivity following 2-D development of TLC plates is discussed, together with the direct identification of TLC spots using mass spectrometry (MS) without having to recover the sample from the plate.

Keywords

Linear Analyzer Fast Atom Bombardment Mass Spectrometry Compact Band Scanning Densitometer Automate Multiple Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • I. D. Wilson
    • 1
  1. 1.Safety of Medicines DepartmentICI Pharmaceuticals DivisionMacclesfield, CheshireUK

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