Abstract
A major advance in the preparation of biological samples for Chromatographic analysis was the introduction of SPE* [which featured strongly in Vol. 16, this series — Ed.]. This methodology involves adsorption of the analyte onto a solid phase (usually a modified silica gel, e.g. C-18 bonded) contained within a disposable cartridge. The compound of interest is then recovered by elution with a suitable solvent. We previously described some unusual and unexpected results obtained with C-18 bonded silica gel SPE cartridges, from two different manufacturers, used for extracting a number of ‘α-blocking’ drugs from plasma [1]. Here we describe further investigations on a wider range of commercially available C-18 cartridges.
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References
Ruane, R.J. & Wilson, I.D. (1987) J. Pharm. Biomed. Anal. 5, 723–727.
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© 1988 Springer Science+Business Media New York
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Ruane, R.J., Wilson, I.D., Tomkinson, G.P. (1988). The Use of Secondary Ionic Interactions for the Solid-Phase Extraction of Some ‘β-Blocking’ Drugs on C-18 Bonded Silica. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_42
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DOI: https://doi.org/10.1007/978-1-4757-9424-3_42
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