Solid-Phase Extraction: Personal Experiences
The large number of types of phases and column sizes available for solid-phase extraction (SPE) makes this a very powerful and versatile sample preparation technique. As most of the available phases are based on those used in HPLC, the analyst is likely to be familiar with their behaviour. Some columns have been developed for particular applications, e.g. phenylboronic acid phases for catecholamine separation. We prefer to consider SPE as an important addition to the extraction techniques available, not necessarily as a replacement. Because of their similarities, some of the points discussed here are also applicable to column-switching techniques.
KeywordsSample Preparation Technique Column Size Trace Enrichment Fast Flow Rate Improve Quality Control
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