Abstract
Pharmaceutical companies having their own R & D organization are increasingly confronted with the severe demands of the registration authorities. Besides the proof of safety and efficacy a third criterion is developing: a new drug in a given therapeutic area must be better than existing ones, in respect of therapeutic effect, fewer or no side-effects, or both criteria. This trend has led to the development of a number of rather potent drugs, having low dose regimes. Besides the implications for departments involved in synthesis and pharmacology, there are consequences for other disciplines such as analysis.
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Abbreviations
- ECD:
-
electron-capture detection
- FBz:
-
fluorobenzoic acid
- PFB(B):
-
pentafluorobenzyl (bromide)
- i.s.:
-
internal standard
- t r :
-
retention time
References
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© 1988 Springer Science+Business Media New York
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de Bree, H. (1988). Analytical Consequences of Potent Drugs. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_37
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DOI: https://doi.org/10.1007/978-1-4757-9424-3_37
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