Assay of Nitroglycerin and Metabolites by Capillary GC

  • Stephen H. Curry
  • Hae-Ryun Kwon
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)


Satisfactory procedures are needed for the assay in plasma of nitroglycerin (glyceryl trinitrate, GTN) and denitrated metabolites, two isomeric dinitroglycerols (1,2- and 1,3-GDN) and mononitroglycerol (GMN; 2 isomers). Besides glycerol itself, metabolism also furnishes inorganic nitrite and, therefrom by reaction with GSH (forming GSSG), nitrate; the desirability of being able to measure these 4 analytes was pointed out at the 1985 Bioanalytical Forum ([1], wherein p. 111 shows metabolic pathways) but is not pursued here.


Packed Column Forensic Context Satisfactory Procedure Miller Health Thermal Energy Analyzer 
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  1. 1.
    Curry, S.H. (1986) in Bioactive Analytes, including CNS Drugs, Peptides and Enantiomers [Vol. 16, this series] (Reid, E., Scales, B. & Wilson, I.D., eds.), Plenum, New York, pp. 109–112.Google Scholar
  2. 2.
    Curry, S.H., Algozzini, G. & Yu, W. (1984) in Drug Determination in Therapeutic and Forensic Contexts [Vol. 14, this series] (Reid, E. & Wilson, I.D., eds.), Plenum, New York, pp. 367–368.CrossRefGoogle Scholar
  3. 3.
    Noonan, P.K., Patrick, K. & Benet, L.Z. (1986) J. Pharrn. Sci. 75, 241–243 [method: Noonan et al. (1984) ibid. 73, 923-927].CrossRefGoogle Scholar
  4. 4.
    Curry, S.H. & Aburawi, S. (1985) Biopharmaceuties & Drug Disp. 6. 235–280.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Stephen H. Curry
    • 1
  • Hae-Ryun Kwon
    • 1
  1. 1.J. Hillis Miller Health CenterCollege of Pharmacy, University of FloridaGainesvilleUSA

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