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The Assay of Hydralazine: A Review

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Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 18 A))

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Abstract

It has long been difficult to determine hydralazine in biological fluids for biopharmaceutical and pharmacokinetic purposes. The drug can react with a number of endogenous compounds, e.g. pyruvic acid or ±-ketoglutaric acid, to form acid-labile hydrazones. Being a base, hydralazine is extractable from biological fluids only at basic pH values where it is unstable, being degraded mainly to phthalazine. A derivatization procedure which can be carried out directly in biological fluids is therefore essential.

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Author information

Authors and Affiliations

  1. Research and Development, Pharmaceuticals Division, Ciba-Geigy Ltd., CH-4002, Basle, Switzerland

    P. H. Degen

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  1. P. H. Degen
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, Guildford, UK

    Eric Reid

  2. Hoechst UK, Milton Keynes, UK

    J. D. Robinson

  3. ICI Pharmaceuticals Division, Macclesfield, UK

    Ian D. Wilson

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© 1988 Springer Science+Business Media New York

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Degen, P.H. (1988). The Assay of Hydralazine: A Review. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_24

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  • DOI: https://doi.org/10.1007/978-1-4757-9424-3_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9426-7

  • Online ISBN: 978-1-4757-9424-3

  • eBook Packages: Springer Book Archive

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