Assay Problems with Nifedipine

  • Peter S. B. Minty
  • Felicity A. Tucker
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)


Nifedipine is a calcium channel antagonist used in the treatment of angina and hypertension. It is sensitive, breaking down in daylight to its nitroso derivative and in UV light to its nitropyridine derivative [1]. Thermal decomposition during GC to the nitropyridine led Kondo et al. [2] to develop a method involving direct oxidation of serum with nitrous acid to the light-tolerant nitropyridine (Fig. 1).


Thermal Decomposition Calcium Channel Antagonist Fuse Silica Column Vitreous Silica Varian Vista 
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  1. 1.
    Testa, R., Dolfini, E., Reschiotto, C., Secchi, C. & Blondi, P.A. (1979) Il Farmaco 34, 463–473.Google Scholar
  2. 2.
    Kondo, S., Kuchiki, A., Yamamoto, K., Akimoto, K., Takahashi, K., Awata, N. & Sugimoto, I. (1980) Chem. Pharm. Bull. 28, 1–7.CrossRefGoogle Scholar
  3. 3.
    Dokladalova, J., Tykal, J., Coco, S.J., Durkee, P.E., Quercia, G.T. & Korst, J.J. (1982) J. Chromatog. 231, 451–458.Google Scholar
  4. 4.
    Tanner, R., Romagnoli, A. & Kramer, W.G. (1986) J. Anal. Toxicol. 10, 250–251.CrossRefGoogle Scholar
  5. 5.
    Tucker, F.A., Minty, P.S.B. & MacGregor, G.A. (1985) J. Chromatog. 342, 193–198.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Peter S. B. Minty
    • 1
  • Felicity A. Tucker
    • 1
    • 2
  1. 1.Department of Forensic Medicine and ToxicologyCharing Cross and Westminster Medical SchoolLondonUK
  2. 2.Servier LaboratoriesFulmer, SloughUK

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