Analytical Approaches Adopted during the Development of Flurbiprofen

  • A. Bye
  • W. Adams
  • D. Kaiser
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)


Brief mention is made of the assay and stereoselective metabolism of ibuprofen. The NSAID given attention in this article is flurbiprofen, the development of which entailed successive assay methods. That outlined below was used when the number of samples to be assayed was escalating.


Propanoic Acid Maximum Daily Dose Drug Development Programme Stereoselective Metabolism Typical HPLC Chromatogram 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



non-steroidal anti-inflammatory drug




reversed phase


internal standard


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  1. 1.
    Litowitz, H., Olanoff, L. & Hoppe, C.L. (1984) J. Chromatog. 311, 443–448.Google Scholar
  2. 2.
    Kaiser, D.G. & Martin, R.S. (1978) J. Pharm. Sci. 67, 627–630.CrossRefGoogle Scholar
  3. 3.
    Kaiser, D.G. & Van Giessen, G.J. (1974) J. Pharm. Sci. 63, 219–221.CrossRefGoogle Scholar
  4. 4.
    Kaiser, D.G., Show, S.R. & Van Giessen, G.J. (1974) J. Pharm. Sci. 63, 567–570.CrossRefGoogle Scholar
  5. 5.
    Risdall, P.C., Adams, S.S., Crampton, E.L. & Marchant, B. (1978) Xenobiotiea 8, 691–704.CrossRefGoogle Scholar
  6. 6.
    Adams, W.J., Bothwell, B.E., Bothwell, W.M., Van Giessen, G.J. & Kaiser, D.G. (1987) Anal. Chem. 59, 1504–1509.CrossRefGoogle Scholar
  7. 7.
    Albert, K.S., Gillespie, W.R., Raabe, A. & Garry, M. (1984) J. Pharm. Sci. 73, 1823–1825.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • A. Bye
    • 1
    • 2
  • W. Adams
    • 1
    • 2
  • D. Kaiser
    • 1
    • 2
  1. 1.Upjohn Ltd.CrawleyUK
  2. 2.The Upjohn CompanyKalamazooUSA

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