Developmental Genetic Trends in Blood Pressure Levels and Blood Pressure Reactivity to Stress

  • Harold Snieder
  • Lorenz J. P. Van Doornen
  • Dorret I. Boomsma
Part of the Perspectives on Individual Differences book series (PIDF)


This chapter has two main aims. The first is to describe the changes in heritability of blood pressure levels and blood pressure reactivity that occur during the life span. The second is to disentangle the genetic and nongenetic causes of stability and change in these parameters. In order to achieve these goals, both empirical studies and developmental models will be discussed.


Diastolic Blood Pressure Blood Pressure Level Cardiovascular Reactivity Twin Correlation Blood Pressure Reactivity 
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  1. Adams, M. A., Bobik, A., and Korner, P. I. (1989). Differential development of vascular and cardiac hypertrophy in genetic hypertension. Relation to sympathetic function. Hypertension, 14, 191–202.PubMedCrossRefGoogle Scholar
  2. Barnes, R. F., Raskind, M., Gumbrecht, G., and Halter, J. B. (1982). The effect of age on the plasma catecholamine response to mental stress in man. Journal of Clinical Endocrinology and Metabolism, 54, 64–69.PubMedCrossRefGoogle Scholar
  3. Sielen, E. C., Fagard, R. H., and Amery, A. K. (1991). Inheritance of blood pressure and haemodynamic phenotypes measured at rest and during supine dynamic exercise. Journal of Hypertension, 9, 655–663.CrossRefGoogle Scholar
  4. Boomsma, D. I. (1992). Quantitative genetic analysis of cardiovascular risk factors in twins and their parents. Thesis: Free University of Amsterdam. Enschede: Febodruk.Google Scholar
  5. Boomsma, D. I., and Molenaar, P. C. M. (1987). The genetic analysis of repeated measures. I. Simplex models. Behavior Genetics, 17, 111–123.PubMedCrossRefGoogle Scholar
  6. Boomsma, D. I., Molenaar, P. C. M., and Dolan, C. V. (1991). Estimation of individual genetic and environmental profiles in longitudinal designs. Behavior Genetics, 21, 241–253.CrossRefGoogle Scholar
  7. Boomsma, D. 1., Orlebeke, J. F., Martin, N. G., Frants, R. R., and Clark, P. (1991) All ha-lantitrypsin and blood pressure. Lancet, 337, 1547.Google Scholar
  8. Boomsma, D. I., van Baal, G. C. M., and Orlebeke, J. F. (1990). Genetic influences on respiratory sinus arrhythmia across different task conditions. Acta Geneticae Medicae et Gemellologiae, 39, 181–191.PubMedGoogle Scholar
  9. Boomsma, D. I., van den Bree, M. B., Orlebeke, J. F., and Molenaar, P. C. M. (1989). Resemblances of parents and twins in sport participation and heart rate. Behavior Genetics, 19, 123–141.PubMedCrossRefGoogle Scholar
  10. Carmelli, D., Ward, M. W., Reed, T., Grim, C. E., Harshfield, G. A., and Fabsitz, R. R. (1991). Genetic effects on cardiovascular responses to cold and mental activity in late adulthood. American Journal of Hypertension, 4, 239–244.PubMedCrossRefGoogle Scholar
  11. Colletto, G. M., Cardon, L. R., and Fulker, D. W. (1993). A genetic and environmental time series analysis of blood pressure in male twins. Genetic Epidemiology, 10, 533–538.PubMedCrossRefGoogle Scholar
  12. De Visser, D. C. (1994). Stress-reactivity in the Dutch Hypertension and Offspring Study: An epidemiological approach to the psychophysiology of early hypertension. Thesis: Erasmus University, Rotterdam.Google Scholar
  13. Ditto, B. (1987). Sibling similarities in cardiovascular reactivity to stress. Psychophysiology, 24, 353–360.PubMedCrossRefGoogle Scholar
  14. Ditto, B. (1993). Familial influences on heart rate, blood pressure, and self-report anxiety responses to stress: Results from 100 twin pairs. Psychophysiology, 30, 635–645.PubMedCrossRefGoogle Scholar
  15. Ditto, B., and France, C. (1990). Similarities within young and middle-aged spouse pairs in behavioral and cardiovascular response to two experimental stressors. Psychosomatic Medicine, 52, 425–434.Google Scholar
  16. Eaves, L. J., Fulker, D., and Heath, A. (1989). The effects of social homogamy and cultural inheritance on the covariances of twins and their parents: A LISREL model. Behavior Genetics, 19, 113–122.PubMedCrossRefGoogle Scholar
  17. Eaves, L. J., Last, K. A., Young, P. A., and Martin, N. G. (1978). Model-fitting approaches to the analysis of human behavior. Heredity, 41, 249–320.PubMedCrossRefGoogle Scholar
  18. Fabsitz, R. R., Carmelli, D., and Hewitt, J. K. (1992). Evidence for independent genetic influences on obesity in middle age. International Journal of Obesity, 16, 657–666.PubMedGoogle Scholar
  19. Faucheux, B. A., Lille, F., Baulon, A., Landau, J., Dupuis, C., and Bourlière, F. (1989). Heart rate and blood pressure reactivity during active coping with a mental task in healthy 18- to 73-yearold subjects. Gerontology, 35, 19–30.PubMedCrossRefGoogle Scholar
  20. Feinleib, M., Garrison, R. J., Fabsitz, R., Christian, J. C., Hrubec, Z., Borhani, N. O., Kannel, W. B., Rosenman, R. H., Schwartz, J. T., and Wagner, J. O. (1977). The NHLBI twin study of cardiovascular disease risk factors: Methodology and summary of results. American Journal of Epidemiology, 106, 284–295.PubMedGoogle Scholar
  21. Folkow, B., Hallback, M., Lundgren, Y., and Weiss, L. (1970). Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats. Acta Physiologica Scandinavica, 80, 93–106.PubMedCrossRefGoogle Scholar
  22. Folkow, B., and Svanborg, A. (1993). Physiology of cardiovascular aging. Physiological Reviews, 73, 725–763.PubMedGoogle Scholar
  23. Furchtgott, E., and Busemeyer, J. K. (1979). Heart rate and skin conductances during cognitive processes as a function of age. Journal of Gerontology, 34, 183–190.PubMedCrossRefGoogle Scholar
  24. Garwood, M., Engel, B. T., and Capriotti, R. (1982). Autonomic nervous system functioning and aging: Response specificity. Psychophysiology, 19, 378–385.PubMedCrossRefGoogle Scholar
  25. Gintner, G. G., Hollandsworth, J. G., and Intrieri, R. C. (1986). Age differences in cardiovascular reactivity under active coping conditions. Psychophysiology, 23, 113–120.Google Scholar
  26. Hanis, C. L., Sing, C. F., Clarke, W. R., and Schrott, H. G. (1983). Multivariate models for human genetic analysis: Aggregation, coaggregation and tracking of systolic blood pressure and weight. American Journal of Human Genetics, 35, 1196–1210.Google Scholar
  27. Harrap, S. B., Van der Merwe, W. M., Griffin, S. A., MacPherson, F., and Lever, A. F. (1990). Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term. Hypertension, 16, 603–614.PubMedCrossRefGoogle Scholar
  28. Havlik, R. J., Garrison, R. J., Feinleib, M., Kannel, W. B., Castelli, W. P., and McNamara, P. M. (1979). Blood pressure aggregation in families. American Journal of Epidemiology, 110, 304–312.PubMedGoogle Scholar
  29. Hewitt, J. K., Carroll, D., Sims, J., and Eaves, L. J. (1987). A developmental hypothesis for adult blood pressure. Acta Geneticae Medicae et Gemellologiae, 36, 475–483.PubMedGoogle Scholar
  30. Hunt, S. C., Hasstedt, S. J., Kuida, H., Stults, B. M., Hopkins, P. N., and Williams, R. R. (1989). Genetic heritability and common environmental components of resting and stressed blood pressures, lipids and body mass index in Utah pedigrees and twins. American Journal of Epidemiology, 129, 625–638.PubMedGoogle Scholar
  31. Iselius, L., Morton, N. E., and Rao, D. C. (1983). Family resemblance for blood pressure. Human Heredity, 33, 277–286.PubMedCrossRefGoogle Scholar
  32. Jöreskog, K. G., and Sörbom, D. (1988). LISREL VII: A guide to the program and applications. Chicago: SPSS Inc.Google Scholar
  33. Kannel, W. B., (1976). Epidemiology of cerebrovascular disease. In R. Ross Russell (Ed.), Cerebral arterial disease (pp. 1–23 ). Edingburgh: Churchill Livingston.Google Scholar
  34. Labarthe, D. R., Mueller, W. H., and Eissa, M. (1991). Blood pressure and obesity in childhood and adolescence: Epidemiological aspects. Annals of Epidemiology, 1, 337–345.PubMedCrossRefGoogle Scholar
  35. Lauer, R. M., Burns, T. L., Clarke, W. R., and Mahoney, L. T. (1991). Childhood predictors of future blood pressure. Hypertension, 18 (Supplement I), 174–184.Google Scholar
  36. Lauer, R. M., and Clarke, W. R. (1989). Childhood risk factors for high adult blood pressure: The Muscatine study. Pediatrics, 84, 633–641.PubMedGoogle Scholar
  37. Lerner, D. J., and Kannel, W. B. (1986). Patterns of coronary heart disease morbidity and mortality in the sexes: A 26-year follow-up of the Framingham population. American Heart Journal, 111, 383–390.PubMedCrossRefGoogle Scholar
  38. Levine, R. S., Hennekens, C. H., Perry, A., Cassady, J., Gelband, H., and Jesse, M. J. (1982). Genetic variance of blood pressure levels in infant twins. American Journal of Epidemiology, 116, 759–764.PubMedGoogle Scholar
  39. Lund-Johansen, P. (1977). Central haemodynamics in essential hypertension. Acta Medica Scandinavica Supplementum, 606, 35–42.PubMedGoogle Scholar
  40. Manuck, S. B., Kasprowicz, A. L., and Muldoon, M. F. (1990). Behaviorally-evoked cardiovascular reactivity and hypertension: Conceptual issues and potential associations. Annals of Behavioral Medicine, 12, 17–29.CrossRefGoogle Scholar
  41. Matthews, K. A., Manuck, S. B., Stoney, C. M., Rakaczky, C. J., McCann, B. S., Saab, P. G., Woodall, K. L., Block, D. R., Visintainer, P. F., and Engebretson, T. O. (1988). Familial aggregation of blood pressure and heart rate responses during behavioral stress. Psychosomatic Medicine, 50, 341–352.PubMedGoogle Scholar
  42. Matthews, K. A., Meilahn, E., Kuller, L. H., Kelsey, S. F., Caggiula, A. W., and Wing, R. R. (1989). Menopause and risk factors for coronary heart disease. New England Journal of Medicine, 321, 641–646.PubMedCrossRefGoogle Scholar
  43. Matthews, K. A., and Stoney, C. M. (1988). Influences of sex and age on cardiovascular responses during stress. Psychosomatic Medicine, 50, 46–56.PubMedGoogle Scholar
  44. Matthews, K. A., Woodall, K. L., and Allen, M. T. (1993). Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension, 22, 479–485.PubMedCrossRefGoogle Scholar
  45. Mcllhany, M. L., Shaffer, J. W., and Hines, E. A. (1975). The heritability of blood pressure: An investigation of 200 pairs of twins using the cold pressor test. Johns Hopkins Medical Journal, 136, 57–64.Google Scholar
  46. Menkes, M. S., Matthews, K. A., Krantz, D. S., Lundberg, U., Mead, L. A., Quaqish, B., Lian, K. Y., Thomas, C. B., and Pearson, T. A. (1989). Cardiovascular reactivity to the cold pressor test as a predictor of hypertension. Hypertension, 14, 524–530.PubMedCrossRefGoogle Scholar
  47. Molenaar, P. C. M., Boomsma, D. I., and Dolan, C. V. (1991). Genetic and environmental factors in a developmental perspective. In D. Magnusson, L. R. Bergman, G. Rudinger, and B. Thorestad (Eds.), Problems and methods in longitudinal research: Stability and change (pp. 250–273 ). Cambridge: Cambridge University Press.CrossRefGoogle Scholar
  48. Parmer, R. J., Cervenka, J. H., and Stone, R. A. (1992). Baroreflex sensitivity and heredity in essential hypertension. Circulation, 85, 497–503.PubMedCrossRefGoogle Scholar
  49. Plomin, R., DeFries, J. C., and McClearn, G. E. (1990). Behavior genetics: A primer. San Francisco: W. H. Freeman.Google Scholar
  50. Pooling Project Research Group (1978). Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the pooling project. Journal of Chronic Diseases, 31, 201–306.CrossRefGoogle Scholar
  51. Province, M. A., and Rao, D. C. (1985). A new model for the resolution of cultural and biological inheritance in the presence of temporal trends: Application to systolic blood pressure, Genetic Epidemiology, 2, 363–374.PubMedCrossRefGoogle Scholar
  52. Rice, T., Vogler, G. P., Perusse, L., Bouchard, C., and Rao, D. C. (1989). Cardiovascular risk factors in a French-Canadian population: Resolution of genetic and familial environmental effects on blood pressure using twins, adoptees, and extensive information on environmental correlates. Genetic Epidemiology, 6, 571–588.PubMedCrossRefGoogle Scholar
  53. Schieken, R. M., Eaves, L. J., Hewitt, J. K., Mosteller, M., Bodurtha, J. N., Moskowitz, W. B., and Nance, W. E. (1989). Univariate genetic analysis of blood pressure in children: The Medical College of Virginia twin study. American Journal of Cardiology, 64, 1333–1337.PubMedCrossRefGoogle Scholar
  54. Shapiro, A. P., Nicotero, J., and Schieb, E. T. (1968). Analysis of the variability of blood pressure, pulse rate, and catecholamine responsivity in identical and fraternal twins. Psychosomatic Medicine, 30, 506–520.PubMedGoogle Scholar
  55. Sims, J., Carroll, D., Hewitt, J. K., and Turner, J. R. (1987). A family study of developmental effects upon blood pressure variation. Acta Geneticae Medicae et Gemellologiae, 36, 467–473.PubMedGoogle Scholar
  56. Sims, J., Hewitt, J. K., Kelly, K. A., Carroll, D., and Tumer, J. R. (1986). Familial and individual influences on blood pressure. Acta Geneticae Medicae et Gemellologiae, 35, 7–21.PubMedGoogle Scholar
  57. Slattery, M. L., Bishop, D. T., French, T. K., Hunt, S. C., Meikle, A. W., and Williams, R. R. (1988). Lifestyle and blood pressure levels in male twins in Utah. Genetic Epidemiology, 5, 277–287.PubMedCrossRefGoogle Scholar
  58. Smith, T. W., Turner, C. W., Ford, M. H., Hunt, S. C., Barlow, G. K., Stults, B. M., and Williams, R. R. (1987). Blood pressure reactivity in adult male twins. Health Psychology, 6, 209–220.PubMedCrossRefGoogle Scholar
  59. Stallings, M. C., Baker, L. A., and Boomsma, D. I. (1989). Estimation of cultural transmission in extended twin designs. Behavior Genetics, 19, 777 (abstract).Google Scholar
  60. Steptoe, A., and Ross, A. (1981). Psychophysiological reactivity and prediction of cardiovascular disorders. Journal of Psychosomatic Research, 25, 23–32.PubMedCrossRefGoogle Scholar
  61. Szklo, M. (1979). Epidemiologic patterns of blood pressure in children. Epidemiological Review, 1, 143–169.Google Scholar
  62. Tambs, K., Eaves, L. J., Moum, T., Holmen, J., Neale, M. C., Naess, S., and Lund-Larsen, P. G. (1993). Age-specific genetic effects for blood pressure. Hypertension, 22, 789–795.PubMedCrossRefGoogle Scholar
  63. Tambs, K., Mourn, T., Holmen, J., Eaves, L. J., Neale, M. C., Lund-Larsen, P. G., and Naess, S. (1992). Genetic and environmental effects on blood pressure in a Norwegian sample. Genetic Epidemiology, 9, 11–26.PubMedCrossRefGoogle Scholar
  64. Theorell, T., DeFaire, U., Schalling, D., Adamson, U., and Askevold, F. (1979). Personality traits and psychophysiological reactions to a stress interview in twins with varying degrees of coronary heart disease. Journal of Psychosomatic Research, 23, 89–99.PubMedCrossRefGoogle Scholar
  65. Turner, J. R. (1994). Cardiovascular reactivity and stress: Patterns of physiological response. New York: Plenum Press.Google Scholar
  66. Turner, J. R., and Hewitt, J. K. (1992). Twin studies of cardiovascular response to psychological challenge: A review and suggested future directions. Annals of Behavioral Medicine, 14, 1220.Google Scholar
  67. Unger, T., and Rettig, R. (1990). Development of genetic hypertension: Is there a “critical phase”? Hypertension, 16, 615–616.PubMedCrossRefGoogle Scholar
  68. Valkenburg, H. A., Hofman, A., Klein, F., and Groustra, F. N. (1980). Een epidemiologisch onderzoek naar risico-indicatoren voor hart-en vaatziekten (EPOZ). I. Bloeddruk, serumcholesterolgehalte, quetelet-index en rookgewoonten in een open bevolking van 5 jaar en ouder. Nederlands Tijdschrift voor Geneeskunde, 124, 183–189.PubMedGoogle Scholar
  69. van Lenthe, R. J., and Kemper, H. C. G. (1993). Risicofactoren voor hart-en vaatziekten en mogelijkheden voor preventie bij tieners: Het Amsterdams Groei en Gezondheid Onderzoek. Hart Bulletin, 24, 171–177.Google Scholar
  70. Weinstock, M., Weksler-Zangen, S., and Schorer-Apelbaum, D. (1986). Genetic factors involved in the determination of baroreceptor heart rate sensitivity. Journal of Hypertension, 4 (Supplement 6), s290 - s292.Google Scholar
  71. Williams, R. R., Hunt, S. C., Hasstedt, S. J., Hopkins, P. N., Wu, L. L., Berry, T. D., Stults, B. M., Barlow, G. K., and Kuida, H. (1990). Hypertension: Genetics and nutrition. In A. P. Simopoulos and B. Childs (Eds.), World review of nutrition and dietetics, Vol. 63, Genetic variation and nutrition (pp. 116–130 ). Basel: S. Karger.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Harold Snieder
    • 1
  • Lorenz J. P. Van Doornen
    • 1
  • Dorret I. Boomsma
    • 1
  1. 1.Department of PsychophysiologyFree University of AmsterdamAmsterdamThe Netherlands

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