Speeding Up the Healing of Burns with Honey
In a pilot-study deep dermal burns, identical in depth and extent, were made at each flank of Yorkshire pigs. Wound healing characteristics and measurements of dermal thickness were investigated by comparing biopsies histologically in pairs. Wounds were treated with either honey of a defined antibacterial activity, or sugar, or silver sulfadiazine (SSD). Biopsies were taken on post burn days 7, 14, 21, 28, 35 and 42. Wounds treated with SSD were fully epithelialized after 28–35 days, whereas those treated with honey and sugar were closed within 21 days. In 5 out of 6 wounds the neodermis of the sugar treated burns was thicker than the neodermis of those treated with honey. In all honey experiments, on day 21, wounds were best microscopically characterized by (i) a quiet granulation tissue, (ii) an inconspicuous inflammation and (iii) a decrease of actine staining of myofibroblasts. In contrast, sugar treated wounds appeared different especially on day 21 and later. Furthermore, we observed in various sections signs of inflammation which were linked to perivascular infiltrates and well-stained myofibroblasts. These results suggest a difference between sugar and honey treatment. If antibacterial activity and anti-inflammatory activity count in wound treatment, then honey has to be prefered above sugar.
KeywordsDermal Thickness Treated Burn Silver Sulfadiazine Degree Burn Honey Treatment
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- 2.Drouet, N. (1983) Utilisation du sucre et du miel dans le traitement des plaies infectées. Nouv Press Med 12, 2355–2356.Google Scholar
- 4.Efem, S.E. (1993) Recent advances in the management of Fournier’s gangrene: Preliminary observations. Surgery 113, 200–204Google Scholar
- 6.Condon, R.E. (1993) Curious interactions of bugs and bees. Surgery 113, 234–235.Google Scholar
- 8.Molan, P.C. and Russel, K.M. (1988) Non-peroxide antibacterial activity in some New Zealand honeys. Journal of Apicultural Research 27, 62–67.Google Scholar
- 9.Hoekstra, MJ, Hupkens, P., Dutrieux, R.P., Bosch, M.M.C and Kreis, R.W. (1993) A comparative burn wound model in the New Yorkshire pig for the histo-pathological evaluation of local therapeutic regimens: silver sulfadiazine cream as a standard. British Journal of Plastic Surgery 46, 585–589.CrossRefGoogle Scholar
- 12.Schmitt-Graff., Desmouliere A. and Gabbiani G. (1994) Heterogeneity of myofibro blastic cell plasticity. Virchows Archive 425, 3–24.Google Scholar
- 13.Schmidt, R.J., Chung, L.Y., Andrews, A.M. and Turner, T.D. (1992). Hydrogen is a murine (L 929) fibroblast cell proliferant at micro-and nanomolar concentrations. In: Second European Conference in advances in wound management. Proc. Int. Conf.Center Harrogate Oct. 20th–23th p. 117-121.Google Scholar
- 14.White, J.W. and Subers, M.H. (1963) Studies on honey inhibine. 2. A chemical assay. Journal of Apicultural Research 2, 93–100.Google Scholar