Abstract
In 1976 we reported and then published in 1978 in greater detail results showing that visual evoked potentials (VEPs), are abnormal in many patients affected by Parkinson’s disease (Bodis-Wollner and Yahr, 1978). This conclusion was somewhat unbelievable, since the disease was considered as an exclusively motor system disorder. Furthermore it was held, since the original description by Halliday and his colleagues (1972) that a ‘delayed’ VEP represents abnormal conduction in the visual pathway due to demyelination, usually caused by multiple sclerosis. Thus, finding that VEPs are delayed in Parkinson’s disease both challenged prior knowledge concerning the extent and nature of the disease, and broadened the interpretation concerning the causes and significance of delayed visual responses. The VEP results in PD suggested that VEP abnormalities may relate to primary neuronal dysfunction in addition to demyelination. Although our results were surprising, there was prior information concerning neuronal dopaminergic mechanisms in visual processing.
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Bodis-Wollner, I. (1995). Impaired Dynamics of Retinal Processing in Dopaminergic Deficiency States in Man and Monkey. In: Robbins, J.G., Djamgoz, M.B.A., Taylor, A. (eds) Basic and Clinical Perspectives in Vision Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9362-8_11
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