Synthesis of α and β Anomers of UDP-N-Acetylmuramic Acid

  • Didier Blanot
  • Geneviève Auger
  • Dominique Liger
  • Jean van Heijenoort
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)

Abstract

UDP-N-acetylmuramyl (UDP-MurNAc) derivatives are substrates for several cytoplasmics steps of the synthesis of bacterial peptidoglycan (Park, 1952). Their availability is a prerequisite for developing the detailed study of the synthetases catalyzing these reactions. Since they are not commercial compounds, they have to be prepared from bacterial cells in which they accumulate under specific conditions. However, such procedures are long and tedious, and yields are often low. An alternative approach is to chemically synthesize UDP-N-acetylmuramic acid on a large scale, and to use it as starting material for the in vitro enzymatic preparation of the other UDP-MurNAc precursors. In this communication, we wish to report the total synthesis of UDP-MurNAc.

Keywords

Uridine Diphosphate Lithium Salt Lithium Hydroxide Polar Peak Muramic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Didier Blanot
    • 1
  • Geneviève Auger
    • 1
  • Dominique Liger
    • 1
  • Jean van Heijenoort
    • 1
  1. 1.Enveloppes Bactériennes et Peptides CNRS URA 1131Université de Paris-SudOrsayFrance

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