Disturbance of Peptidoglycan Synthesis by Glycine and D-Methionine Creates a Signal for the ampG-Mediated Induction of AmpC-β-Lactamase in Escherichia coli

  • Hans H. Martin
  • Herbert Schmidt
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)


It has been reasoned that bacterial β-lactamases must have a “normal” physiological function, apart from inactivating β-lactam antibiotics, probably connected to the metabolism of cell wall peptidoglycan (Abraham and Chain, 1940; Saz and Lowery, 1979). In the same context, evidence has been brought forward which points to an essential role of peptidoglycan metabolism in the induced synthesis of β-lactamase in Gram-positive and Gram-negative bacteria (Collins, 1979; Tuomanen et al., 1991).


Enterobacter Cloaca Shake Culture Cell Wall Peptidoglycan Citrobacter Freundii Peptidoglycan Synthesis 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Hans H. Martin
    • 1
  • Herbert Schmidt
    • 1
  1. 1.Institut für MikrobiologieTechnische HochschuleDarmstadtGermany

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