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Molecular Characteristics of the Cell Wall Lytic Enzymes Coded by Pneumococcal Phages

  • Pedro García
  • Ernesto García
  • Alicia Romero
  • Christian Croux
  • Concepción Ronda
  • Rubens López
  • José L. García
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)

Abstract

The biochemical characteristics of the enzymes postulated to participate in the lysis of Streptococcus pneumonioe infected by phages have been studied in our laboratory in some detail (García et al., 1984, 1987; Romero et al., 1990). Independently of their enzymatic specificity, either amidases or lysozymes, most of the lytic enzymes found in pneumococcus and its bacteriophages share important properties, especially the absolute requirement for choline-containing teichoic acid in cell wall substrate (a peculiar characteristic of the pneumococcal peptidoglycan) for activity (Höltje and Tomasz, 1975). It has been postulated that this choline dependence of the pneumococcal lysins may have served as an element of selective pressure during evolution that should have preserved the structures of these enzymes (García et al., 1988 a).

Keywords

Streptococcus Pneumoniae Lytic Enzyme Teichoic Acid Clostridium Acetobutylicum Modular Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Pedro García
    • 1
  • Ernesto García
    • 1
  • Alicia Romero
    • 1
  • Christian Croux
    • 1
  • Concepción Ronda
    • 1
  • Rubens López
    • 1
  • José L. García
    • 1
  1. 1.Unidad de Génetica Bacteriana Centro de Investigaciones BiológicasConsejo Superior de Investigaciones CientíficasMadridSpain

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