Inhibition of an Autolysin Together with PBP3 Causes the Formation of Bulges: Identification of the Soluble Lytic Tranglycosylase in E. coli as the Specific Target of Bulgecin
A coordinated action of murein synthetases and murein hydrolases is assumed to be essential for proper growth of the bacterial cell. A disturbance of this balance, for example by blocking parts of the synthetic pathway turns the hydrolases into autolysins which then cause lysis of the cell (Tomasz, 1979).
KeywordsPenicillin Binding Protein Beta Lactam Antibiotic Beta Lactam Bacterial Metabolite Muramic Acid
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