Does PBP2 Regulate Cell Division in E. coli?

  • Philippe Bouloc
  • Daniel Vinella
  • Danièle Joseleau-Petit
  • Richard D’Ari
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)


Although penicillin has not made war humane, it probably saved over a million lives during World War II. The action of penicillin and related β-lactam antibiotics was early recognized to be extrmely broad, affecting the vast majority of bacterial species, and at the same time highly specific, generally producing little effect on eukaryotic cells. As the complex structure of the bacterial cell wall became known, the mechanism of action of β-lactams was also revealed: they bind covalently to the PBPs (‘penicillin binding proteins’), a set of integral membrane proteins which catalyse the terminal steps in the synthesis of the rigid peptoglycan wall (for review see Waxman and Strominger, 1983; Ghuysen, 1991).


Wild Type Strain Glycan Chain Muramic Acid Peptidoglycan Synthesis Transpeptidase Activity 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Philippe Bouloc
    • 1
  • Daniel Vinella
    • 1
  • Danièle Joseleau-Petit
    • 1
  • Richard D’Ari
    • 1
  1. 1.Institut Jacques MonodC.N.R.S., Université Paris 7Paris Cedex 05France

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