Activities of FDA’s Division of Nutrition Regarding Cholesterol Oxides

  • Alan J. Sheppard
  • Chih-shang J. Shen
Chapter

Abstract

The Food and Drug Administration (FDA), as one of the Federal Government’s primary consumer protection agencies, has responsibility for assuring that Americans receive safe, sanitary and properly labelled foods, drugs, cosmetics and medical devices. The Division of Nutrition, Bureau of Foods, shares the major responsibility for safeguarding the nutritional quality and safety of the nation’s food supply.

Keywords

High Performance Liquid Chromatography Lithocholic Acid Cholesterol Oxidation Product Sterol Metabolism Cholesterol Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A.A. Kandutsch and H.W. Chen, Inhibition of sterol synthesis in cultured mouse cells by 7ß -hydroxycholesterol, 7ß-hydroxycholesterol and 7-ketocholesterol, J. Biol. Chem. 248: 8048 (1973).Google Scholar
  2. 2.
    J.J. Bell, T.E. Sargent, and J.A. Watson, Inhibition of 3-hydroxy-3-methylglutaryl Coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives, J. Biol. Chem. 251: 1745 (1976).Google Scholar
  3. 3.
    A.A. Kandutsch and H.W. Chen, Inhibition of cholesterol synthesis by oxygenated sterols, Lipids 13: 704 (1978).CrossRefGoogle Scholar
  4. 4.
    A.A. Kandutsch, H.W. Chen, and H-J. Heiniger, Biological activity of some oxygenated sterols, Science 201: 498 (1978).CrossRefGoogle Scholar
  5. 5.
    J.D.B. MacDougall, S. Biswas, and R.P. Cook, The effect of certain C27 steroids on organ cultures of rabbit aorta, Br. J. Exp. Pathol. 46: 549 (1965).Google Scholar
  6. 6.
    H.W. Chen, A.A. Kandutsch, and C. Waymouth, Inhibition of cell growth by oxygenated derivatives of cholesterol, Nature 251: 419 (1974).CrossRefGoogle Scholar
  7. 7.
    H. Imai, N.T. Werthessen, C.B. Taylor, and K.T. Lee, Angiotoxicity and atherosclerosis due to contaminants of USP-grade cholesterol, Arch. Pathol. Lab. Med. 100: 565 (1976).Google Scholar
  8. 8.
    S.K. Peng, C.B. Taylor, P. Tham, N.T. Werthessen, and B. Mikkelson, Effect of auto-oxidation product from cholesterol on aortic smooth muscle cells, Arch. Pathol. Lab. Med. 102: 57 (1978).Google Scholar
  9. 9.
    C.B. Taylor, S.K. Peng, N.T. Werthessen, P. Tham, and K.T. Lee, Spontaneously occuring angiotoxic derivatives of cholesterol, Am. J. Clin. Nutr. 32: 40 (1979).Google Scholar
  10. 10.
    S.K. Peng, P. Tham, C.B. Taylor, and B. Mikkelson, Cytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis, Am. J. Clin. Nutr. 32: 1033 (1979).Google Scholar
  11. 11.
    F. Bischoff, Carcinogenic effects of steroids, Advan. Lipid Res. 7: 165 (1969).Google Scholar
  12. 12.
    H.S. Black and W.B. Lo, Formation of a carcinogen in human skin irradiated with ultraviolet light, Nature 234: 306 (1971).CrossRefGoogle Scholar
  13. 13.
    H.S. Black and D.R. Douglas, A model system for the evaluation of the role of cholesterol a-oxide in ultraviolet carcinogenesis, Cancer Res. 32: 2630 (1972).Google Scholar
  14. 14.
    W.B. Lo and H.S. Black, Formation of cholesterol derived photo-products in human skin, J. Invest. Dermatol. 58: 278 (1972).CrossRefGoogle Scholar
  15. 15.
    W.B. Lo and H.S. Black, Inhibition of carcinogen formation in skin irradiated with ultraviolet light, Nature 246: 489 (1973).CrossRefGoogle Scholar
  16. 16.
    J.T. Chan and H.S. Black, Skin carcinogenesis: Cholesterol-5a,6a-epoxide hydrase activity in mice skin irradiated with ultraviolet light, Science 186: 1716 (1974).CrossRefGoogle Scholar
  17. 17.
    M.I. Kelsey and R.J. Pienta, Transformation of hamstere mbryo cells by cholesterol-a-epoxide and lithocholic acid. Cancer Lett. 6: 143 (1979).CrossRefGoogle Scholar
  18. 18.
    L. Acker and H. Greve, Uder die photoxydation des cholesterins in eihaltigen lebensmitteln, Fette-Seifen-Anstrichmittel, 65: 1009 (1963).CrossRefGoogle Scholar
  19. 19.
    L.D. Williams and A.M. Pearson, Unsaponifiable fraction of pork fat as related to boar odor, J. Agric. Food Chem. 13: 537 (1965).CrossRefGoogle Scholar
  20. 20.
    C. Tu, W.D. Powrie, and O. Fennema, Free and esterified cholesterol content of animal muscles and meat products, J. Food Sci. 32: 30 (1967).CrossRefGoogle Scholar
  21. 21.
    E. Chicoye, W.D. Powrie, and O. Fennema, Photoxidation of cholesterol in spray-dried egg yolk upon irradiation, J. Food Sci. 33: 581 (1968).CrossRefGoogle Scholar
  22. 22.
    C.B. Taylor, S.K. Peng, H. Imai, B. Mikkelson, K.T. Lee, and N.T. Werthesson, Hereditary hyperlipidemia in chicken-model for study of toxic oxidation products found in significant amounts in U.S.P. cholesterol, powdered eggs and milk, in:“Atherosclerosis,” G.W. Manning and D. Daria Huast, ed., Plenum Press, New York (1977).Google Scholar
  23. 23.
    L.L. Smith, W.S. Mathews, J.C. Price, R.C. Bachmann, and B. Reynolds, Thin-layer chromatographic examination of cholesterol autoxidation, J. Chromatogr. 27: 187 (1967).CrossRefGoogle Scholar
  24. 24.
    C. Horvath, Quantitative determination of cholesterol in autoxidation mixtures by thin-layer chromatography, J. Chromatogr. 22: 52 (1966).CrossRefGoogle Scholar
  25. 25.
    J.E. Van Lier and L.L. Smith, Sterol metabolism II. Gas chromatographic recognition of cholesterol metabolites and artifacts, Anal. Biochem. 24: 419 (1968).Google Scholar
  26. 26.
    J.E. Van Lier and L.L. Smith, Crystalline sterols obtained by gas chromatography, J. Chromatogr. 36: 7 (1968).CrossRefGoogle Scholar
  27. 27.
    J.E. Van Lier and L.L. Smith, Chromatography of some cholesterol autoxidation products on Sephadex LH-20, J. Chromatogr. 41: 37 (1969).Google Scholar
  28. 28.
    J.E. Van Lier and L.L. Smith, Sterol metabolism XII. 26-Hydroxycholesterol in commercial cholesterol, Lipids 6: 85 (1971).CrossRefGoogle Scholar
  29. 29.
    L.L. Smith and F.L. Hill, Detection of sterol hydroperoxides on thin-layer chromatoplates by means of the Wurster dyes, J. Chromatogr. 66: 101 (1972).CrossRefGoogle Scholar
  30. 30.
    J.I. Teng and L.L. Smith, Anomalous chromatographic behaviour of some C27-sterol hydroperoxides, J. Chromatogr. 115: 648 (1975).CrossRefGoogle Scholar
  31. 31.
    J.E. Van Lier, A.L. Da Costa, and L.L. Smith, Cholesterol autoxidation: Identification of the volatile fragments, Lipids 14: 327 (1975).CrossRefGoogle Scholar
  32. 32.
    G.A.S. Ansari and L.L. Smith, Sterol metabolism XLI. Cholesterol A-ring autoxidation, Chem. Phys. Lipids 22: 55 (1978).CrossRefGoogle Scholar
  33. 33.
    J. Redel and J. Capillon, Resolution of epimeric (25R)- and (25S)-hydroxycholesterol by high-pressure liquid chromatography, J. Chromatogr. 155: 418 (1978).Google Scholar
  34. 34.
    L.L. Smith, M.J. Kulig, D. Miller, and G.A.S. Ansari, Oxidation of cholesterol by dioxygen species, J. Am. Chem. Soc. 100: 6206 (1978).CrossRefGoogle Scholar
  35. 35.
    G.A.S. Ansari and L.L. Smith, High-performance liquid chromatography of cholesterol autoxidation products, J. Chromatogr. 175: 307 (1979).CrossRefGoogle Scholar
  36. 36.
    I.W. Duncan, P.C. Culbreth, and C.A. Burtis, Determination of free, total and esterified cholesterol by high-performance liquid chromatography, J. Chromatogr. 162: 281 (1979).CrossRefGoogle Scholar
  37. 37.
    G. Galli and M. Gallikienle, New mass fragmentographic method for the evaluation of cholesterol-7-hydroxylase activity and of tissue levels of oxygenated derivatives of cholesterol, Italian J. Biochem. 28: 323 (1979).Google Scholar
  38. 38.
    J.E. Van Lier and L.L. Smith, Thermal decomposition of some cholesterol hydroperoxides, Steroids 15: 485 (1970).CrossRefGoogle Scholar
  39. 39.
    L.L. Smith, M.J. Kulig, and J.I. Teng, Sterol metabolism XXVI. Pyrolysis of some sterol allylic alcohols and hydroperoxides, Steroids 22: 627 (1973).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Alan J. Sheppard
    • 1
  • Chih-shang J. Shen
    • 1
  1. 1.Div. of NutritionFood and Drug AdminUSA

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