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Spin Trapping of Radical Species Involved in the Propagation of Lipid Peroxidation

  • Gerald M. Rosen
  • Elmer J. Rauckman
  • Eli Finkelstein

Abstract

Lipid peroxidation is a naturally occurring process involving the generation of free radicals mainly derived from the polyunsaturated fatty acids that are incorporated into the phosphoglycerides of membranes. The peroxidative process has been shown to be a radical chain reactive sequence which has separate initiation, propagation and termination steps.1 Initiation is thought to occur either by a radical addition to a double bond or by abstraction of an allylic hydrogen by a reactive radical. In either case, generation of an appropriate chain initiating radical must preceed the propagation reactions.

Keywords

Electron Spin Resonance Carbon Tetrachloride Spin Trap Cumene Hydroperoxide Spin Trapping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Gerald M. Rosen
    • 1
  • Elmer J. Rauckman
    • 1
  • Eli Finkelstein
    • 1
  1. 1.Departments of Pharmacology and SurgeryDuke University Medical CenterDurhamUSA

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