Is Peroxidation Important in the Cancer Process

  • Raymond J. Shamberger


Natural antioxidants such as selenium and vitamins C, E, as well as the phenolic antioxidants, BHA and BHT have inhibited several types of tumors.


Sodium Selenite Phenolic Antioxidant Meat Treatment Spontaneous Mammary Tumor Pork Chop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cameron, E. and Campbell, A., 1974, The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer, Chem.-Biol. Interact.,9:285.CrossRefGoogle Scholar
  2. Carroll, K.K. and Khor, H.T., 1970, Effects of dietary fat and dose level of 7,12-dimethylbenzanthracene on mammary tumor incidence in rats, Cancer Res., 30: 2260.Google Scholar
  3. Carroll, K.K. and Khor, H.T., 1971, Effects of level and type of dietary fat on incidence of mammary tumors induced in Sprague-Dawley rats by 7,12-dimethylbenzanthracene, Lipids ,6: 415.CrossRefGoogle Scholar
  4. Clayton, C.C. and Baumann, C.A., 1949, Diet and azo dye tumors; effect of diet during a period when the dye is not fed, Cancer Res.,9: 575.Google Scholar
  5. DeCosse, J.J., Adams, M.B., Kuzma, J.F., LoGerfo, P. and Condon, R.E., 1975, Effect of ascorbic acid on rectal polyps of patients with familial polyposis, Surgery ,78: 608.Google Scholar
  6. Drasar, B.S. and Irving, D., 1973, Environmental factors and cancer of the colon and breast, Br. J. Cancer ,27:167.Google Scholar
  7. Dungal, N. and Sigurjonsson, J., 1967, Gastric cancer and diet. A pilot study on dietary habits in two districts differing markedly in respect of mortality from gastric cancer, Brit. J. Cancer ,21:270.Google Scholar
  8. Frankfurt, O.S., Lipchina, L.P., Bunto, T.V., 1967, The influence of 4-methyl-2,6-tert-butylphenol (Ionol) on the development of hepatic tumors in rats, Bull. Exp. Biol. Med. (USSR) ,8:86.Google Scholar
  9. Gammal, E.B., Carroll, K.K., Plunkett, E.R., 1967, Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenzanthracene in rats, Cancer Res.,27: 1737.Google Scholar
  10. Griffin, A.C. and Jacobs, M.M., 1977, Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett.,3: 177.Google Scholar
  11. Haber, S.L. and Wissler, R.W., 1962, Effect of vitamin E on carcinogenicity of methylcholanthrene, Proc. Soc. Exp. Biol. Med.,111:774.Google Scholar
  12. Harman, D., 1969, Dibenzanthracene induced cancer. Inhibition effect of dietary vitamin E, Clin. Res.,17:125.Google Scholar
  13. Harr, J.R., Exon, J.H., Whanger, P.D. and Weswig, P.H., 1972, Effect dietary selenium on N-2 fluorenyl-acetamide (FAA)-induced cancer in vitamin E supplemented, selenium depleted rats, Clin. Toxicol.,5:187.Google Scholar
  14. Hopkins, G.J., West, C.E. and Hard, G.C., 1976, Effect of dietary fats on the incidence of 7,12-dimethylbenzanthracene-induced tumors in rats, Lipids ,11: 328.Google Scholar
  15. Jacobs, M.M., Jansson, B., and Griffin, A.C., 1977, Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett.,2: 133.Google Scholar
  16. Jaffe, W., 1946, The influence of wheat germ oil on the production of tumors in rats by methylcholanthrene, Exp. Med. Surg.,4:278.Google Scholar
  17. Lee, C. and Chen, C., 1979, Enhancement of mammary tumorigenesis in rats by vitamin E deficiency, Proc. Am. Assoc. Cancer Res.,20:132.Google Scholar
  18. Marshall, M.V., Jacobs, M.M. and Griffin, A.C., 1978, Reduction in acetylaminofluorene (AAF) hepatocarcinogenesis by selenium, Proc. Am. Assoc. Cancer Res.,19:75.Google Scholar
  19. Mirvish, S.S., Wallace, L., Eagen, M. and Shubek, P., 1972, Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic compounds, Science ,177: 65.Google Scholar
  20. Mukai, F.H. and Goldstein, B.D., 1976, Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids, Science ,191: 868.Google Scholar
  21. Reddy, B.S. and Hirota, N., 1979, Effect of dietary ascorbic acid on 1,2-dimethylhydrazine-induced colon cancer in rats,Fed. Proc.,38:714.Google Scholar
  22. Riley, J.F., 1968, Mast cells, co-carcinogenesis and anticarcinogenesis in the skin of mice, Experientia ,15: 1231.Google Scholar
  23. Scnlegel, J.U., Pipkin, G.E., Nishumura, R. and Shultz, G.N., 1969, the role of ascorbic acid in the prevention of bladder tumor formation, Trans. Amer. Assoc. Genito-Urinary Surg., 61:85.Google Scholar
  24. Schrauzer, G.N. and Ishmael, D., 1974, Effects of selenium and arsenic on the genesis of spontaneous mammary tumors in inbred C H mice, Ann. Clin. Lab. Sci.,4:441.Google Scholar
  25. Schrauzer, G. White, D.A. and Schneider, C.J., 1977, Cancer mortality correlation studies-III:Statistical association with dietary selenium intakes, Bioinorganic Chem.,7: 23.Google Scholar
  26. Slaga, T.J. and Bracken, W.M., 1977, The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase, Cancer Res.,37: 1631.Google Scholar
  27. Shamberger, R.J. and Rudolph, G., 1966, Protection against cocarcinogenesis by antioxidants, Experientia ,22: 116.Google Scholar
  28. Shamberger, R.J., 1970, Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis, J. Nat. Cancer Inst.,44:931.Google Scholar
  29. Shamberger, R.J. and Willis, C.E., 1971, Selenium distribution and human cancer mortality, C.R.C. Crit. Rev. Clin. Lab,Sci.2:221Google Scholar
  30. Shamberger, R.J., 1972, Increase of peroxidation in carcinogenesis, J. Nat. Cancer Inst.,48:1491.Google Scholar
  31. Shamberger, R.J., Baughman, F.F., Kalchert, S.L., Willis, C.E. and Hoffman, G.C., 1973a, Carcinogen-induced chromosomal breakage decreased by antioxidants, Proc. Nat. Acad. Sci .(U.S.A.), 70:1461.Google Scholar
  32. Shamberger, R.J., Rukovena, E., Longfield, A.K., Tytko, S.A., Deodhar, S. and Willia, C.E., 1973b, Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients, J. Nat. Cancer Inst.,50:863.Google Scholar
  33. Shamberger, R.J., Andreone, T.L. and Willis, C.E., 1974, Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen, J. Natl. Cancer Inst.,53:1771.Google Scholar
  34. Shamberger, R.J., Tytko, S.A. and Willis, C.E., 1976, Antioxidants and cancer. VI. Selenium and age-adjusted human cancer mortality, Arch. Environ. Health ,31:235.Google Scholar
  35. Shamberger, R.J., Shamberger, B.A. and Willis, C.E., 1977, Malonaldehyde content of food, J. Nutr.,107:1404.Google Scholar
  36. Shamberger, R.J., Corlett, C.L., Beaman, K.D. and Kasten, B.L., 1979, Antioxidants reduce the mutagenic effect of malonaldehyde and ß-propiolactone, Mutation Res.,66: 349.Google Scholar
  37. Ulland, B.M., Weisburger, J.H., Yamamoto, R.S., and Weisburger, E., 1973, Antioxidants and carcinogenesis: Butylated hydroxytoluene but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxyN-2-f luorenylacetamide in rats, Food Cosmet. Toxicol.,11:199.Google Scholar
  38. Vithayatheil, A.J., Commoner, B., Nair, S. and Madyastha, P., 1978, Isolation of mutagens from bacterial nutrients containing beef extracts, J. Toxicol. Environ. Health ,4:189.CrossRefGoogle Scholar
  39. Wattenberg, L.W., 1972, Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin, J. Natl. Cancer Inst.,48:1425.Google Scholar
  40. Wattenberg, L.W., 1972, Inhibition of carcinogenic effects of diethylnitrosamine and 4-nitroquinoline-N-oxide by antioxidants, Fed. Proc.,31:633.Google Scholar
  41. Weisburger, E.K., Evarts, R.P., Wenk, M.L., 1977, Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane, Food Cosmet.,15: 139.Google Scholar
  42. Wattenberg, L.W., 1973, Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole, J. Natl. Cancer Inst.,50:1541.Google Scholar
  43. Yamafuji, J., Nakamura, Y., Omura, H., Soeda, T. and Gyotoku, K., 1971, Antitumor potency of ascorbic, dehydroascorbic, or 2,3-diketogulonic acid and their action of deoxyribonucleic acid, A. Krebsforsch. Klin. Onkol.,76:1.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Raymond J. Shamberger
    • 1
  1. 1.The Cleveland Clinic FoundationClevelandUSA

Personalised recommendations