Abstract
Natural antioxidants such as selenium and vitamins C, E, as well as the phenolic antioxidants, BHA and BHT have inhibited several types of tumors.
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References
Cameron, E. and Campbell, A., 1974, The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer, Chem.-Biol. Interact.,9:285.
Carroll, K.K. and Khor, H.T., 1970, Effects of dietary fat and dose level of 7,12-dimethylbenzanthracene on mammary tumor incidence in rats, Cancer Res., 30: 2260.
Carroll, K.K. and Khor, H.T., 1971, Effects of level and type of dietary fat on incidence of mammary tumors induced in Sprague-Dawley rats by 7,12-dimethylbenzanthracene, Lipids ,6: 415.
Clayton, C.C. and Baumann, C.A., 1949, Diet and azo dye tumors; effect of diet during a period when the dye is not fed, Cancer Res.,9: 575.
DeCosse, J.J., Adams, M.B., Kuzma, J.F., LoGerfo, P. and Condon, R.E., 1975, Effect of ascorbic acid on rectal polyps of patients with familial polyposis, Surgery ,78: 608.
Drasar, B.S. and Irving, D., 1973, Environmental factors and cancer of the colon and breast, Br. J. Cancer ,27:167.
Dungal, N. and Sigurjonsson, J., 1967, Gastric cancer and diet. A pilot study on dietary habits in two districts differing markedly in respect of mortality from gastric cancer, Brit. J. Cancer ,21:270.
Frankfurt, O.S., Lipchina, L.P., Bunto, T.V., 1967, The influence of 4-methyl-2,6-tert-butylphenol (Ionol) on the development of hepatic tumors in rats, Bull. Exp. Biol. Med. (USSR) ,8:86.
Gammal, E.B., Carroll, K.K., Plunkett, E.R., 1967, Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenzanthracene in rats, Cancer Res.,27: 1737.
Griffin, A.C. and Jacobs, M.M., 1977, Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett.,3: 177.
Haber, S.L. and Wissler, R.W., 1962, Effect of vitamin E on carcinogenicity of methylcholanthrene, Proc. Soc. Exp. Biol. Med.,111:774.
Harman, D., 1969, Dibenzanthracene induced cancer. Inhibition effect of dietary vitamin E, Clin. Res.,17:125.
Harr, J.R., Exon, J.H., Whanger, P.D. and Weswig, P.H., 1972, Effect dietary selenium on N-2 fluorenyl-acetamide (FAA)-induced cancer in vitamin E supplemented, selenium depleted rats, Clin. Toxicol.,5:187.
Hopkins, G.J., West, C.E. and Hard, G.C., 1976, Effect of dietary fats on the incidence of 7,12-dimethylbenzanthracene-induced tumors in rats, Lipids ,11: 328.
Jacobs, M.M., Jansson, B., and Griffin, A.C., 1977, Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett.,2: 133.
Jaffe, W., 1946, The influence of wheat germ oil on the production of tumors in rats by methylcholanthrene, Exp. Med. Surg.,4:278.
Lee, C. and Chen, C., 1979, Enhancement of mammary tumorigenesis in rats by vitamin E deficiency, Proc. Am. Assoc. Cancer Res.,20:132.
Marshall, M.V., Jacobs, M.M. and Griffin, A.C., 1978, Reduction in acetylaminofluorene (AAF) hepatocarcinogenesis by selenium, Proc. Am. Assoc. Cancer Res.,19:75.
Mirvish, S.S., Wallace, L., Eagen, M. and Shubek, P., 1972, Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic compounds, Science ,177: 65.
Mukai, F.H. and Goldstein, B.D., 1976, Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids, Science ,191: 868.
Reddy, B.S. and Hirota, N., 1979, Effect of dietary ascorbic acid on 1,2-dimethylhydrazine-induced colon cancer in rats,Fed. Proc.,38:714.
Riley, J.F., 1968, Mast cells, co-carcinogenesis and anticarcinogenesis in the skin of mice, Experientia ,15: 1231.
Scnlegel, J.U., Pipkin, G.E., Nishumura, R. and Shultz, G.N., 1969, the role of ascorbic acid in the prevention of bladder tumor formation, Trans. Amer. Assoc. Genito-Urinary Surg., 61:85.
Schrauzer, G.N. and Ishmael, D., 1974, Effects of selenium and arsenic on the genesis of spontaneous mammary tumors in inbred C H mice, Ann. Clin. Lab. Sci.,4:441.
Schrauzer, G. White, D.A. and Schneider, C.J., 1977, Cancer mortality correlation studies-III:Statistical association with dietary selenium intakes, Bioinorganic Chem.,7: 23.
Slaga, T.J. and Bracken, W.M., 1977, The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase, Cancer Res.,37: 1631.
Shamberger, R.J. and Rudolph, G., 1966, Protection against cocarcinogenesis by antioxidants, Experientia ,22: 116.
Shamberger, R.J., 1970, Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis, J. Nat. Cancer Inst.,44:931.
Shamberger, R.J. and Willis, C.E., 1971, Selenium distribution and human cancer mortality, C.R.C. Crit. Rev. Clin. Lab,Sci.2:221
Shamberger, R.J., 1972, Increase of peroxidation in carcinogenesis, J. Nat. Cancer Inst.,48:1491.
Shamberger, R.J., Baughman, F.F., Kalchert, S.L., Willis, C.E. and Hoffman, G.C., 1973a, Carcinogen-induced chromosomal breakage decreased by antioxidants, Proc. Nat. Acad. Sci .(U.S.A.), 70:1461.
Shamberger, R.J., Rukovena, E., Longfield, A.K., Tytko, S.A., Deodhar, S. and Willia, C.E., 1973b, Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients, J. Nat. Cancer Inst.,50:863.
Shamberger, R.J., Andreone, T.L. and Willis, C.E., 1974, Antioxidants and cancer. IV. Initiating activity of malonaldehyde as a carcinogen, J. Natl. Cancer Inst.,53:1771.
Shamberger, R.J., Tytko, S.A. and Willis, C.E., 1976, Antioxidants and cancer. VI. Selenium and age-adjusted human cancer mortality, Arch. Environ. Health ,31:235.
Shamberger, R.J., Shamberger, B.A. and Willis, C.E., 1977, Malonaldehyde content of food, J. Nutr.,107:1404.
Shamberger, R.J., Corlett, C.L., Beaman, K.D. and Kasten, B.L., 1979, Antioxidants reduce the mutagenic effect of malonaldehyde and ß-propiolactone, Mutation Res.,66: 349.
Ulland, B.M., Weisburger, J.H., Yamamoto, R.S., and Weisburger, E., 1973, Antioxidants and carcinogenesis: Butylated hydroxytoluene but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxyN-2-f luorenylacetamide in rats, Food Cosmet. Toxicol.,11:199.
Vithayatheil, A.J., Commoner, B., Nair, S. and Madyastha, P., 1978, Isolation of mutagens from bacterial nutrients containing beef extracts, J. Toxicol. Environ. Health ,4:189.
Wattenberg, L.W., 1972, Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin, J. Natl. Cancer Inst.,48:1425.
Wattenberg, L.W., 1972, Inhibition of carcinogenic effects of diethylnitrosamine and 4-nitroquinoline-N-oxide by antioxidants, Fed. Proc.,31:633.
Weisburger, E.K., Evarts, R.P., Wenk, M.L., 1977, Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane, Food Cosmet.,15: 139.
Wattenberg, L.W., 1973, Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole, J. Natl. Cancer Inst.,50:1541.
Yamafuji, J., Nakamura, Y., Omura, H., Soeda, T. and Gyotoku, K., 1971, Antitumor potency of ascorbic, dehydroascorbic, or 2,3-diketogulonic acid and their action of deoxyribonucleic acid, A. Krebsforsch. Klin. Onkol.,76:1.
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Shamberger, R.J. (1980). Is Peroxidation Important in the Cancer Process. In: Simic, M.G., Karel, M. (eds) Autoxidation in Food and Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9351-2_33
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DOI: https://doi.org/10.1007/978-1-4757-9351-2_33
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