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Lipid Peroxidation: The Role of Hepatic FAD-Monooxygenase

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Autoxidation in Food and Biological Systems

Abstract

Lipid peroxidation is a process which occurs in biological membranes, and which has been implicated in many instances of in vitro and in vivo damage.1 The hepatic microsomal fraction is known to readily undergo lipid peroxidation. Extensive research has been conducted to attempt to clarify this process which has been shown to involve the hepatic microsomal cytochrome P-450 mixed function oxidase system. In this review we will discuss the properties of another hepatic microsomal enzyme, FAD*-containing monooxygenase. In addition we will summarize the peroxidative mechanism as it is currently understood and present evidence that FAD-containing monooxygenase is involved in the lipid peroxidation of hepatic microsomes.

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Surgery, Duke University Medical Center, Durham, N.C., USA

    Julia D. George, Gerald M. Rosen & Elmer J. Rauckman

  2. Clayton Foundation Biochemical Institute and Department of Chemistry, The University of Texas at Austin, Austin, Texas, USA

    Daniel M. Ziegler

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  1. Julia D. George
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  2. Gerald M. Rosen
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  3. Elmer J. Rauckman
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  4. Daniel M. Ziegler
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Editor information

Editors and Affiliations

  1. Center for Radiation Research, National Bureau of Standards, Washington, D.C., USA

    Michael G. Simic

  2. Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Marcus Karel

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George, J.D., Rosen, G.M., Rauckman, E.J., Ziegler, D.M. (1980). Lipid Peroxidation: The Role of Hepatic FAD-Monooxygenase. In: Simic, M.G., Karel, M. (eds) Autoxidation in Food and Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9351-2_28

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  • DOI: https://doi.org/10.1007/978-1-4757-9351-2_28

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4757-9351-2

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