Despite the widespread use of amphotericin B and azote antifungal agents, hematogenously disseminated infections caused by Candida species are a serious problem in hospitalized patients. Candida species continue to be the fourth most common cause of nosocomial septicemia, accounting for 5% to 10% of all nosocomial bloodstream infections. This incidence of candidemia surpasses the incidence of bacteremia caused by Escherechia coli or Klebsiella species. Furthermore, Candida species are the most common cause of deep-seated fungal infections in patients who have extensive burns or who have undergone orthotopic liver or bone marrow transplantation. In many cases, an indwelling vascular catheter is considered to be the portal of entry. In fact, Candida species are the third most common cause of catheter-related infections, causing 11% of these infections.
KeywordsCandida Albicans Candida Species Germ Tube Candida Glabrata Candida Parapsilosis
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- 2.Bodey GP: Candidiasis: Pathogenesis, Diagnosis, and Treatment, 2nd Ed. New York: Raven Press; 1993.Google Scholar
- 6.Edwards JE: Candida species. In Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases, 4th Ed. Edited by Mandell GL, Bennett JH, Dolin R. New York: Churchill Livingstone; 1995: 2289–2306.Google Scholar
- 7.Crissey JT, Lang H, Parish LC: Manual of Medical Mycology. Woburn: Blackwell Science, 1995.Google Scholar
- 9.Pfaller MA, Houston A, Coffman S: Application of CHROMagar Candida for rapid screening of clinical specimens for Candida albicans, Canidida tropicales, Candida krusei and Candida (Torulopsis) glabrata. J Clin Microbiol 1996, 34: 58–61.Google Scholar
- 10.Thaler M, Pastakia B, Shawker TH, Hepatic candidiasis in cancer patients: the evolving picture of the syndrome. Ann Intern Med 1988, 108:88–100.Google Scholar
- 11.Clemente CD, ed.: Gray’s Anatomy, 30th ed. Philadelphia: Lea & Febiger; 1985.Google Scholar
- 12.Edwards JE Jr. Candida endophlhalmitis. In Current Clinical Topics in Infectious Diseases. Edited by Remington JS, Swartz MN. New York: McGraw-Hill; 1982: 386.Google Scholar
- 14.Herzog CA, Carson P, Michaud L, Asinger RW: Two-dimensional echocardiographic imaging of left ventricular vegetations. Am Heart J 1988, 115: 684–686.Google Scholar
- 15.Gallis HA, Sobel JD: Candiduria. In Atlas of Infectious Diseases, vol 9. Edited by Mandell GL, Sobel JD. Philadelphia: Current Medicine; 1997:5. 1–5. 15.Google Scholar
- 16.Kwon-Chung, KJ, Bennett JE: Candidiasis. In Medical Mycology. Philadelphia: Lea & Febiger; 1992: 280–336.Google Scholar